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Systematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor

Authors: Yung-Hsin Huang, Chun-Wei Chen, Venkatasubramaniam Sundaramurthy, Mikolaj Slabicki, Dapeng Hao, Caroline J Watson, Ayala Tovy, Jaime M Reyes, Olga Dakhova, Brielle R Crovetti, Christina Galonska, Minjung Lee, Lorenzo Brunetti, Yubin Zhou, Katrina Tatton-Brown, Yun Huang, Xiaodong Cheng, Alexander Meissner, Peter J M Valk, Lionel Van Maldergem, Mathijs A Sanders, Jamie R Blundell, Wei Li, Benjamin L Ebert, Margaret A Goodell

Journal: Cancer Discov

PubMed ID: 34429321

Doi: 10.1158/2159-8290.CD-21-0560

Products & Services: Proteins, Expression, Isolation and Analysis

Hsp40s play complementary roles in the prevention of tau amyloid formation

Authors: Rose Irwin, Ofrah Faust, Ivana Petrovic, Sharon Grayer Wolf, Hagen Hofmann, Rina Rosenzweig

Journal: Elife

PubMed ID: 34369377

Doi: 10.7554/eLife.69601

Products & Services: Proteins, Expression, Isolation and Analysis

Single dose rVSVΔG-JUNVGP vaccine protects guinea pigs against lethal Junin virus challenge

Authors: Teresa E Sorvillo, Robert W Cross, Dylan M Johnson, Natalie S Dobias, Karla A Fenton, Chad E Mire, Thomas W Geisbert

Journal: npj Vaccines

PubMed ID: 34373461

Doi: 10.1038/s41541-021-00361-0

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An infrared spectral biomarker accurately predicts neurodegenerative disease class in the absence of overt symptoms

Authors: Lila Lovergne, Dhruba Ghosh, Renaud Schuck, Aris A Polyzos, Andrew D Chen, Michael C Martin, Edward S Barnard, James B Brown, Cynthia T McMurray

Journal: Sci Rep

PubMed ID: 34341363

Doi: 10.1038/s41598-021-93686-8

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Cross-neutralization of RBD mutant strains of SARS-CoV-2 by convalescent patient derived antibodies

Authors: Yan Lou, Wenxiang Zhao, Haitao Wei, Min Chu, Ruihua Chao, Hangping Yao, Junwei Su, Yanan Li, Xiulan Li, Yu Cao, Yanyan Feng, Ping Wang, Yongyang Xia, Yushuan Shang, Fengping Li, Pingju Ge, Xinglin Zhang, Wenjing Gao, Gaojie Song, Bing Du, Tingbo Liang, Yunqing Qiu, Mingyao Liu

Journal: Biotechnol J

PubMed ID: 34379353

Doi: 10.1002/biot.202100207

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The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

Authors: Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Sebastian Schafer, Fathima F Kuthubudeen, Anissa A Widjaja, Stuart A Cook

Journal: Elife

PubMed ID: 34435951

Doi: 10.7554/eLife.68843

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Ribosylation of the CD8αβ heterodimer permits binding of the nonclassical major histocompatibility molecule, H2-Q10

Authors: Katharine Jennifer Goodall, Angela Nguyen, Daniel Mark Andrews, Lucy Catherine Sullivan

Journal: J Biol Chem

PubMed ID: 34478713

Doi: 10.1016/j.jbc.2021.101141

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The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice light sheet microscopy

Authors: Shayne E Quinn, Lu Huang, Jason G Kerkvliet, Joel A Swanson, Steve Smith, Adam D Hoppe, Robert B Anderson, Natalie W Thiex, Brandon L Scott

Journal: Nat Commun

PubMed ID: 34376698

Doi: 10.1038/s41467-021-25187-1

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Self-assembling synthetic nanoadjuvant scaffolds cross-link B cell receptors and represent new platform technology for therapeutic antibody production

Authors: Sujata Senapati, Ross J Darling, Kathleen A Ross, Michael J Wannemeuhler, Balaji Narasimhan, Surya K Mallapragada

Journal: Sci Adv

PubMed ID: 34348905

Doi: 10.1126/sciadv.abj1691

Products & Services: Proteins, Expression, Isolation and Analysis

Equine pituitary pars intermedia dysfunction: a spontaneous model of synucleinopathy

Authors: Jessica S Fortin, Ashley A Hetak, Kelsey E Duggan, Caroline M Burglass, Hailey B Penticoff, Harold C Schott

Journal: Sci Rep

PubMed ID: 34362943

Doi: 10.1038/s41598-021-95396-7

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Integrative multi-omics profiling reveals cAMP-independent mechanisms regulating hyphal morphogenesis in Candida albicans

Authors: Kyunghun Min, Thomas F Jannace, Haoyu Si, Krishna R Veeramah, John D Haley, James B Konopka

Journal: PLoS Pathog

PubMed ID: 34398936

Doi: 10.1371/journal.ppat.1009861

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Vesicular Stomatitis Virus Chimeras Expressing the Oropouche Virus Glycoproteins Elicit Protective Immune Responses in Mice

Authors: Sarah Hulsey Stubbs, Marjorie Cornejo Pontelli, Nischay Mishra, Changhong Zhou, Juliano de Paula Souza, Rosa Maria Mendes Viana, W Ian Lipkin, David M Knipe, Eurico Arruda, Sean P J Whelan

Journal: MBio

PubMed ID: 34340542

Doi: 10.1128/mBio.00463-21

Products & Services: Mammalian Expression

The Role of Hexokinase and Hexose Transporters in Preferential Use of Glucose over Fructose and Downstream Metabolic Pathways in the Yeast

Authors: Piotr Hapeta, Patrycja Szczepańska, Tadeusz Witkowski, Jean-Marc Nicaud, Anne-Marie Crutz-Le Coq, Zbigniew Lazar

Journal: Int J Mol Sci

PubMed ID: 34502217

Doi: 10.3390/ijms22179282

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Secondary Structure of Human Evolved Gene Product NCYM Analyzed by Vacuum-Ultraviolet Circular Dichroism

Authors: Tatsuhito Matsuo, Kazuma Nakatani, Taiki Setoguchi, Koichi Matsuo, Taro Tamada, Yusuke Suenaga

Journal: Front Oncol

PubMed ID: 34497756

Doi: 10.3389/fonc.2021.688852

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Novel allosteric ligands of the angiotensin receptor AT1R as autoantibody blockers

Authors: Khuraijam Dhanachandra Singh, Zaira P Jara, Terri Harford, Prasenjit Prasad Saha, Triveni R Pardhi, Russell Desnoyer, Sadashiva S Karnik

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34380734

Doi: 10.1073/pnas.2019126118

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Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern

Authors: Wenwei Li, Yaozong Chen, Jérémie Prévost, Irfan Ullah, Maolin Lu, Shang Yu Gong, Alexandra Tauzin, Romain Gasser, Dani Vézina, Sai Priya Anand, Guillaume Goyette, Debashree Chaterjee, Shilei Ding, William D Tolbert, Michael W Grunst, Yuxia Bo, Shijian Zhang, Jonathan Richard, Fei Zhou, Rick K Huang, Lothar Esser, Allison Zeher, Marceline Côté, Priti Kumar, Joseph Sodroski, Di Xia, Pradeep D Uchil, Marzena Pazgier, Andrés Finzi, Walther Mothes

Journal: biorxiv

PubMed ID: 34373853

Doi: 10.1101/2021.08.02.454546

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CRISPR-Cas9-mediated reactivation of the uricase pseudogene in human cells prevents acute hyperuricemia

Authors: Lais de Lima Balico, Eric A Gaucher

Journal: Mol Ther Nucleic Acids

PubMed ID: 34589279

Doi: 10.1016/j.omtn.2021.08.002

Products & Services: Mammalian Expression

Blockade of Autocrine CCL5 Responses Inhibits Zika Virus Persistence and Spread in Human Brain Microvascular Endothelial Cells

Authors: Megan C Mladinich, Jonas N Conde, William R Schutt, Sook-Young Sohn, Erich R Mackow

Journal: MBio

PubMed ID: 34399621

Doi: 10.1128/mBio.01962-21

The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output

Authors: Dimitris C Kanellis, Jaime A Espinoza, Asimina Zisi, Elpidoforos Sakkas, Jirina Bartkova, Anna-Maria Katsori, Johan Boström, Lars Dyrskjøt, Helle Broholm, Mikael Altun, Simon J Elsässer, Mikael S Lindström, Jiri Bartek

Journal: Sci Adv

PubMed ID: 34348895

Doi: 10.1126/sciadv.abf7561

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Multiple epitopes of hepatitis B virus surface antigen targeted by human plasma-derived immunoglobulins coincide with clinically observed escape mutations

Authors: Sreya Tarafdar, Maria Luisa Virata, Hailing Yan, Lilin Zhong, Lu Deng, Yanqun Xu, Yong He, Evi Struble, Pei Zhang

Journal: J Med Virol

PubMed ID: 34406663

Doi: 10.1002/jmv.27278

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Complete and efficient conversion of plant cell wall hemicellulose into high-value bioproducts by engineered yeast

Authors: Liang Sun, Jae Won Lee, Sangdo Yook, Stephan Lane, Ziqiao Sun, Soo Rin Kim, Yong-Su Jin

Journal: Nat Commun

PubMed ID: 34404791

Doi: 10.1038/s41467-021-25241-y

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The Use of CRISPR/Cas9 as a Tool to Study Human Infectious Viruses

Authors: Huafeng Lin, Gang Li, Xiangwen Peng, Aimin Deng, Lei Ye, Lei Shi, Tuanmei Wang, Jun He

Journal: Front Cell Infect Microbiol

PubMed ID: 34513721

Doi: 10.3389/fcimb.2021.590989

Digestive Enzyme Activity and Protein Degradation in Plasma of Heart Failure Patients

Authors: Vasiliki Courelli, Alla Ahmad, Majid Ghassemian, Chris Pruitt, Paul J Mills, Geert W Schmid-Schönbein

Journal: Cell Mol Bioeng

PubMed ID: 34900012

Doi: 10.1007/s12195-021-00693-w

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Identification and in-silico characterization of taxadien-5α-ol-O-acetyltransferase (TDAT) gene in Corylus avellana L

Authors: Mona Raeispour Shirazi, Sara Alsadat Rahpeyma, Sajad Rashidi Monfared, Jafar Zolala, Azadeh Lohrasbi-Nejad

Journal: PLoS ONE

PubMed ID: 34449796

Doi: 10.1371/journal.pone.0256704

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Recombinant Antigens Based on Non-Glycosylated Regions from RBD SARS-CoV-2 as Potential Vaccine Candidates against COVID-19

Authors: Leandro Núñez-Muñoz, Gabriel Marcelino-Pérez, Berenice Calderón-Pérez, Miriam Pérez-Saldívar, Karla Acosta-Virgen, Hugo González-Conchillos, Brenda Vargas-Hernández, Ana Olivares-Martínez, Roberto Ruiz-Medrano, Daniela Roa-Velázquez, Edgar Morales-Ríos, Jorge Ramos-Flores, Gustavo Torres-Franco, Diana Peláez-González, Jorge Fernández-Hernández, Martha Espinosa-Cantellano, Diana Tapia-Sidas, José Abrahan Ramírez-Pool, América Padilla-Viveros, Beatriz Xoconostle-Cázares

Journal: Vaccines (Basel)

PubMed ID: 34452053

Doi: 10.3390/vaccines9080928

Products & Services: Recombinant Proteins

Deep immune profiling of the maternal-fetal interface with mild SARS-CoV-2 infection

Authors: Suhas Sureshchandra, Michael Z Zulu, Brianna Doratt, Allen Jankeel, Delia Tifrea, Robert Edwards, Monica Rincon, Nicole E Marshall, Ilhem Messaoudi

Journal: biorxiv

PubMed ID: 34462741

Doi: 10.1101/2021.08.23.457408

Products & Services: Proteins, Expression, Isolation and Analysis

Simultaneous Multiplex Genome Engineering Accelerated Natural Transformation in

Authors: Aihua Deng, Zhaopeng Sun, Tiantian Wang, Di Cui, Lai Li, Shuwen Liu, Fei Huang, Tingyi Wen

Journal: Front Microbiol

PubMed ID: 34484154

Doi: 10.3389/fmicb.2021.714449

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Comparative phylogenetic analysis of CBL reveals the gene family evolution and functional divergence in Saccharum spontaneum

Authors: Xiaomin Feng, Yongjun Wang, Nannan Zhang, Shuai Gao, Jiayun Wu, Rui Liu, Yonghong Huang, Jisen Zhang, Yongwen Qi

Journal: BMC Plant Biol

PubMed ID: 34425748

Doi: 10.1186/s12870-021-03175-3

Products & Services: Protein Tools

Characterization of murine cytomegalovirus infection and induction of calcification in Murine Aortic Vascular Smooth Muscle Cells (MOVAS)

Authors: Cassandra M Bonavita, Timothy M White, Brent A Stanfield, Rhonda D Cardin

Journal: J Virol Methods

PubMed ID: 34461152

Doi: 10.1016/j.jviromet.2021.114270

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Nontypeable P5 Binds Human C4b-Binding Protein, Promoting Serum Resistance

Authors: Oskar Thofte, Serena Bettoni, Yu-Ching Su, John Thegerström, Sandra Jonsson, Emma Mattsson, Linda Sandblad, Sara Martí, Junkal Garmendia, Anna M Blom, Kristian Riesbeck

Journal: J Immunol

PubMed ID: 34433620

Doi: 10.4049/jimmunol.2100105

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An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination

Authors: Yongchao Wang, Ningqiang Gong, Chi Ma, Yuxuan Zhang, Hong Tan, Guangchao Qing, Jimei Zhang, Yufei Wang, Jinjin Wang, Shizhu Chen, Xianlei Li, Qiankun Ni, Yuan Yuan, Yaling Gan, Junge Chen, Fangzhou Li, Jinchao Zhang, Caiwen Ou, Yongxiang Zhao, Xiaoxuan Liu, Xing-Jie Liang

Journal: Nat Commun

PubMed ID: 34400628

Doi: 10.1038/s41467-021-25197-z

Products & Services: Recombinant Antibody Expression

A chimeric virus-based probe unambiguously detects live circulating tumor cells with high specificity and sensitivity

Authors: Xinping Fu, Lihua Tao, Xiaoliu Zhang

Journal: Mol Ther Methods Clin Dev

PubMed ID: 34631928

Doi: 10.1016/j.omtm.2021.08.007

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Evidence of neutralizing antibodies against SARS-CoV-2 in domestic cats living with owners with a history of COVID-19 in Lima - Peru

Authors: Luis M Jara, Cusi Ferradas, Francesca Schiaffino, Camila Sánchez-Carrión, Ana Martínez-Vela, Alexandra Ulloa, Gisela Isasi-Rivas, Angela Montalván, Luis Guevara Sarmiento, Manolo Fernández, Mirko Zimic

Journal: One Health

PubMed ID: 34462726

Doi: 10.1016/j.onehlt.2021.100318

Products & Services: Proteins, Expression, Isolation and Analysis

A [3Fe-4S] cluster and tRNA-dependent aminoacyltransferase BlsK in the biosynthesis of Blasticidin S

Authors: Xiankun Wang, Yuchun Zhao , Yaojie Gao , Xiangkun Luo , Aiqin Du , Zixin Deng , T. Mark Zabriskied , Xinyi Hea, and Ming Jiang

Journal: PNAS

PubMed ID: 34282016

Doi: 10.1073/pnas.2102318118

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Chemerin/ChemR23 signaling mediates the effects of ultra-high molecular weight polyethylene wear particles on the balance between osteoblast and osteoclast differentiation

Authors: Fengchao Zhao, Dingwei Cang, Jianzhi Zhang, Li Zheng

Journal: Ann Transl Med

PubMed ID: 34430590

Doi: 10.21037/atm-21-2945

Products & Services: Molecular Biology Reagents

Immunogenicity Studies of Plant-Produced SARS-CoV-2 Receptor Binding Domain-Based Subunit Vaccine Candidate with Different Adjuvant Formulations

Authors: Konlavat Siriwattananon, Suwimon Manopwisedjaroen, Balamurugan Shanmugaraj, Eakachai Prompetchara, Chutitorn Ketloy, Supranee Buranapraditkun, Kittipan Tharakhet, Papatsara Kaewpang, Kiat Ruxrungtham, Arunee Thitithanyanont, Waranyoo Phoolcharoen

Journal: Vaccines (Basel)

PubMed ID: 34358160

Doi: 10.3390/vaccines9070744

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Lipopolysaccharide Binding Protein and CD14, Cofactors of Toll-like Receptors, Are Essential for Low-Grade Inflammation-Induced Exacerbation of Cartilage Damage in Mouse Models of Posttraumatic Osteoarthritis

Authors: Yoonkyung Won, Jeong-In Yang, Seulki Park, Jang-Soo Chun

Journal: Arthritis Rheumatol

PubMed ID: 33559324

Doi: 10.1002/art.41679

Products & Services: Recombinant Proteins

Interferon-beta, interferon-gamma and their fusion interferon of Siberian tigers (Panthera tigris altaica) in China are involved in positive-feedback regulation of interferon production

Authors: Mengyao Mu, Hongjing Zhao, Yu Wang, Menghao Guo, Xiaopan Nie, Yachen Liu, Mingwei Xing

Journal: Dev Comp Immunol

PubMed ID: 34329648

Doi: 10.1016/j.dci.2021.104211

Products & Services: Recombinant Antibody Expression

RNase κ promotes robust piRNA production by generating 2',3'-cyclic phosphate-containing precursors

Authors: Megumi Shigematsu, Takuya Kawamura, Keisuke Morichika, Natsuko Izumi, Takashi Kiuchi, Shozo Honda, Venetia Pliatsika, Ryuma Matsubara, Isidore Rigoutsos, Susumu Katsuma, Yukihide Tomari, Yohei Kirino

Journal: Nat Commun

PubMed ID: 34301931

Doi: 10.1038/s41467-021-24681-w

Products & Services: Recombinant Antibody Expression

Cryo-EM structure of human Wntless in complex with Wnt3a

Authors: Qing Zhong, Yanyu Zhao, Fangfei Ye, Zaiyu Xiao, Gaoxingyu Huang, Meng Xu, Yuanyuan Zhang, Xiechao Zhan, Ke Sun, Zhizhi Wang, Shanshan Cheng, Shan Feng, Xiuxiu Zhao, Jizhong Zhang, Peilong Lu, Wenqing Xu, Qiang Zhou, Dan Ma

Journal: Nat Commun

PubMed ID: 34315898

Doi: 10.1038/s41467-021-24731-3

Products & Services: Proteins, Expression, Isolation and Analysis

Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2

Authors: Qi Zhang, Bin Ju, Jiwan Ge, Jasper Fuk-Woo Chan, Lin Cheng, Ruoke Wang, Weijin Huang, Mengqi Fang, Peng Chen, Bing Zhou, Shuo Song, Sisi Shan, Baohua Yan, Senyan Zhang, Xiangyang Ge, Jiazhen Yu, Juanjuan Zhao, Haiyan Wang, Li Liu, Qining Lv, Lili Fu, Xuanling Shi, Kwok Yung Yuen, Lei Liu, Youchun Wang, Zhiwei Chen, Linqi Zhang, Xinquan Wang, Zheng Zhang

Journal: Nat Commun

PubMed ID: 34244522

Doi: 10.1038/s41467-021-24514-w

Products & Services: Proteins, Expression, Isolation and Analysis

Contributions of S- and R-citalopram to the citalopram-induced modulation of the function of Nav15 voltage-gated sodium channels

Authors: Yoshihiko Nakatani, Taku Amano

Journal: Eur J Pharmacol

PubMed ID: 34280395

Doi: 10.1016/j.ejphar.2021.174316

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Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7-Expressing Carcinoma in the Cervicovaginal Tract

Authors: Talia R Henkle, Brandon Lam, Yu Jui Kung, John Lin, Ssu-Hsueh Tseng, Louise Ferrall, Deyin Xing, Chien-Fu Hung, T-C Wu

Journal: Cancer Res

PubMed ID: 34215618

Doi: 10.1158/0008-5472.CAN-21-0399

Products & Services: Plasmid DNA Preparation

Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle

Authors: Ahmad Jomaa, Simon Eitzinger, Zikun Zhu, Sowmya Chandrasekar, Kan Kobayashi, Shu-Ou Shan, Nenad Ban

Journal: Cell Rep

PubMed ID: 34260909

Doi: 10.1016/j.celrep.2021.109350

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A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1

Authors: Seppe Leysen, Rebecca Jane Burnley, Elizabeth Rodriguez, Lech-Gustav Milroy, Lorenzo Soini, Carolyn J Adamski, Larissa Nitschke, Rachel Davis, Tomas Obsil, Lucas Brunsveld, Tom Crabbe, Huda Yahya Zoghbi, Christian Ottmann, Jeremy Martin Davis

Journal: J Mol Biol

PubMed ID: 34302818

Doi: 10.1016/j.jmb.2021.167174

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The expansion of activated naive DNA autoreactive B cells and its association with disease activity in systemic lupus erythematosus patients

Authors: Kittikorn Wangriatisak, Chokchai Thanadetsuntorn, Thamonwan Krittayapoositpot, Chaniya Leepiyasakulchai, Thanitta Suangtamai, Pintip Ngamjanyaporn, Ladawan Khowawisetsut, Prasong Khaenam, Chavachol Setthaudom, Prapaporn Pisitkun, Patchanee Chootong

Journal: Arthritis Res Ther

PubMed ID: 34229724

Doi: 10.1186/s13075-021-02557-0

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Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling

Authors: Monique S Straub, Carolina Alvadia, Marta Sawicka, Raimund Dutzler

Journal: Elife

PubMed ID: 34263724

Doi: 10.7554/eLife.69800

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Half-life extension of efficiently produced DARPin serum albumin fusions as a function of FcRn affinity and recycling

Authors: Hannes Merten, Fabian Brandl, Martina Zimmermann, Jonas V Schaefer, Linda Irpinio, Kine M K Sand, Jeannette Nilsen, Jan Terje Andersen, Uwe Zangemeister-Wittke, Andreas Plückthun

Journal: Eur J Pharm Biopharm

PubMed ID: 34303832

Doi: 10.1016/j.ejpb.2021.07.011

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Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs

Authors: Kai Xu, Yiran Wang, Chen-Hsiang Shen, Yiwei Chen, Baoshan Zhang, Kevin Liu, Yaroslav Tsybovsky, Shuishu Wang, S Katie Farney, Jason Gorman, Tyler Stephens, Raffaello Verardi, Yongping Yang, Tongqing Zhou, Gwo-Yu Chuang, Antonio Lanzavecchia, Luca Piccoli, Peter D Kwong

Journal: Nat Commun

PubMed ID: 34244481

Doi: 10.1038/s41467-021-24291-6

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MicroRNA-138 Increases Chemo-Sensitivity of Glioblastoma through Downregulation of Survivin

Authors: Ji-Young Yoo, Margaret Yeh, Yin-Ying Wang, Christina Oh, Zhong-Ming Zhao, Balveen Kaur, Tae-Jin Lee

Journal: Biomedicines

PubMed ID: 34356844

Doi: 10.3390/biomedicines9070780

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