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Recombinant Bacillus subtilis flagellin Hag is a potent immunostimulant with reduced proinflammatory properties compared to Salmonella enterica serovar Typhimurium FljB

Authors: Mélanie Côté-Cyr, Laurie Gauthier, Ximena Zottig, Steve Bourgault, Denis Archambault

Journal: Vaccine

PubMed ID: 34844822

Doi: 10.1016/j.vaccine.2021.11.049

Products & Services: Gene Synthesis

Enhancing the resilience of transgenic cotton for insect resistance

Authors: Mohsin Shad, Aneela Yasmeen, Saira Azam, Allah Bakhsh, Ayesha Latif, Naila Shahid, Sahar Sadaqat, Abdul Qayyum Rao, Ahmad Ali Shahid

Journal: Mol Biol Rep

PubMed ID: 34839448

Doi: 10.1007/s11033-021-06972-z

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Inhibition of SGLT1 alleviates the glycemic variability-induced cardiac fibrosisvia inhibiting activations of macrophage and cardiac fibroblast

Authors: Weihua Wu, Qian Chai, Ziying Zhang

Journal: MOL CELL BIOL

PubMed ID: 34842443

Doi: 10.1128/MCB.00282-21

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Genetic manipulation of trehalose-6-phosphate synthase results in changes in the soluble sugar profile in transgenic sugarcane stems

Authors: Casey Gabriel, Jean-Jacque Fernhout, Franziska Fichtner, Regina Feil, John E Lunn, Jens Kossmann, James R Lloyd, Christell van der Vyver

Journal: Plant Direct

PubMed ID: 34765864

Doi: 10.1002/pld3.358

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MmpL3, the trehalose monomycolate transporter, is stable in solution in several detergents and can be reconstituted into peptidiscs

Authors: Kien Lam Ung, Husam Alsarraf, Laurent Kremer, Mickaël Blaise

Journal: Protein Expr Purif

PubMed ID: 34767949

Doi: 10.1016/j.pep.2021.106014

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A SYBR Green-based real-time RT-PCR assay to differentiate the H1N1 influenza virus lineages

Authors: Yulin Cong, Yixue Sun, Xiaoyu Deng, Haiying Yu, Xiaohuan Lian, Yanlong Cong

Journal: J Virol Methods

PubMed ID: 34848281

Doi: 10.1016/j.jviromet.2021.114387

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ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis

Authors: Charles J Cho, Dongkook Park, Jason C Mills

Journal: Am J Physiol Gastrointest Liver Physiol

PubMed ID: 34816763

Doi: 10.1152/ajpgi.00246.2021

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Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis

Authors: Mark A J M Hendriks, Isabel Britsch, Xiurong Ke, Anne P van Wijngarden, Douwe F Samplonius, Emily M Ploeg, Wijnand Helfrich

Journal: Oncoimmunology

PubMed ID: 34858730

Doi: 10.1080/2162402X.2021.2005344

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LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway

Authors: Ying Xing, Yang Liu, Zhong Qi, Zhengrong Liu, Xin Wang, Hongyi Zhang

Journal: Cell Mol Biol Lett

PubMed ID: 34837962

Doi: 10.1186/s11658-021-00295-4

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H, N and C resonance assignments of the Q61H mutant of human KRAS bound to GDP

Authors: Qiwei Huang, Elizabeth Yihui Ng, Qingxin Li, CongBao Kang

Journal: Biomol NMR Assign

PubMed ID: 34787842

Doi: 10.1007/s12104-021-10058-z

Products & Services: Mammalian Expression

Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling

Authors: Anna Spier, Michael G Connor, Thomas Steiner, Filipe Carvalho, Pascale Cossart, Wolfgang Eisenreich, Timothy Wai, Fabrizia Stavru

Journal: Cell Rep

PubMed ID: 34758302

Doi: 10.1016/j.celrep.2021.109989

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Quantitative contributions of TNF receptor superfamily members to CD8 T-cell responses

Authors: John Nguyen, Johannes Pettmann, Philipp Kruger, Omer Dushek

Journal: Mol Syst Biol

PubMed ID: 34806839

Doi: 10.15252/msb.202110560

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Accelerated discovery of novel glycoside hydrolases using targeted functional profiling and selective pressure on the rumen microbiome

Authors: André L A Neves, Jiangkun Yu, Yutaka Suzuki, Marisol Baez-Magana, Elena Arutyunova, Eóin O'Hara, Tim McAllister, Kim H Ominski, M Joanne Lemieux, Le Luo Guan

Journal: Microbiome

PubMed ID: 34814938

Doi: 10.1186/s40168-021-01147-1

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Tegument Protein pp150 Sequence-Specific Peptide Blocks Cytomegalovirus Infection

Authors: Dipanwita Mitra, Mohammad H Hasan, John T Bates, Gene L Bidwell, Ritesh Tandon

Journal: Viruses

PubMed ID: 34835083

Doi: 10.3390/v13112277

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Agonist/Antagonist Activity of Oxytocin Variants Obtained from Free Cyclic Peptide Libraries Generated via Amino Acid Substitution

Authors: Remi Kinoshita, Ikko Kozaki, Kazunori Shimizu, Takahiro Shibata, Akihito Ochiai, Hiroyuki Honda

Journal: ACS Omega

PubMed ID: 34841168

Doi: 10.1021/acsomega.1c04982

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Involvement of the Heat Shock Protein HtpG of Typhimurium in Infection and Proliferation in Hosts

Authors: Tao Dong, Weiwei Wang, Minhao Xia, Shujie Liang, Guangzhong Hu, Hui Ye, Qingyun Cao, Zemin Dong, Changming Zhang, Dingyuan Feng, Jianjun Zuo

Journal: Front Cell Infect Microbiol

PubMed ID: 34869065

Doi: 10.3389/fcimb.2021.758898

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Calcium-Responsive Diguanylate Cyclase CasA Drives Cellulose-Dependent Biofilm Formation and Inhibits Motility in Vibrio fischeri

Authors: Alice H Tischler, Michael E Vanek, Natasha Peterson, Karen L Visick

Journal: MBio

PubMed ID: 34749532

Doi: 10.1128/mBio.02573-21

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MiR-574-5P, miR-1827, and miR-4429 as Potential Biomarkers for Schizophrenia

Authors: Omran Davarinejad, Sajad Najafi, Hossein Zhaleh, Farzaneh Golmohammadi, Farnaz Radmehr, Mostafa Alikhani, Reza Heidari Moghadam, Yazdan Rahmati

Journal: J Mol Neurosci

PubMed ID: 34811713

Doi: 10.1007/s12031-021-01945-0

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CD4+ effector T cells accelerate Alzheimer's disease in mice

Authors: Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L Namminga, Katherine E Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y Poluektova, Channabasavaiah B Gurumurthy, R Lee Mosley, Howard E Gendelman

Journal: J Neuroinflammation

PubMed ID: 34798897

Doi: 10.1186/s12974-021-02308-7

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Long noncoding RNA CRART16 confers 5-FU resistance in colorectal cancer cells by sponging miR-193b-5p

Authors: Jingui Wang, Xiaoqian Zhang, Junling Zhang, Shangwen Chen, Jing Zhu, Xin Wang

Journal: Cancer Cell Int

PubMed ID: 34844630

Doi: 10.1186/s12935-021-02353-5

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Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation

Authors: Elie Hammam, Ameya Sinha, Sebastian Baumgarten, Flore Nardella, Jiaqi Liang, Samia Miled, Frédéric Bonhomme, Diane Erdmann, Benoit Arcangioli, Paola B Arimondo, Peter Dedon, Peter Preiser, Artur Scherf

Journal: MBio

PubMed ID: 34724812

Doi: 10.1128/mBio.02558-21

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Recombinant Human HPS Protects Mice and Nonhuman Primates from Acute Liver Injury

Authors: Yang Yang, Huali Zhai, Yue Wan, Xiaofang Wang, Hui Chen, Lihou Dong, Taoyun Liu, Guifang Dou, Chutse Wu, Miao Yu

Journal: Int J Mol Sci

PubMed ID: 34884691

Doi: 10.3390/ijms222312886

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Comparative proteomics reveals Cryptosporidium parvum manipulation of the host cell molecular expression and immune response

Authors: Teng Li, Hua Liu, Nan Jiang, Yiluo Wang, Ying Wang, Jing Zhang, Yujuan Shen, Jianping Cao

Journal: PLoS Negl Trop Dis

PubMed ID: 34818332

Doi: 10.1371/journal.pntd.0009949

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Gasdermin D inhibition confers antineutrophil mediated cardioprotection in acute myocardial infarction

Authors: Kai Jiang, Zizhuo Tu, Kun Chen, Yue Xu, Feng Chen, Sheng Xu, Tingting Shi, Jie Qian, Lan Shen, John Hwa, Dandan Wang, Yaozu Xiang

Journal: J Clin Invest

PubMed ID: 34752417

Doi: 10.1172/JCI151268

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Diacylglycerol kinase A is essential for polymyxin resistance provided by EptA, MCR-1 and other lipid A phosphoethanolamine transferases

Authors: Alexandria B Purcell, Bradley J Voss, M Stephen Trent

Journal: J Bacteriol

PubMed ID: 34843376

Doi: 10.1128/JB.00498-21

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Expression and purification of a native Thy1-single-chain variable fragment for use in molecular imaging

Authors: Natacha Jugniot, Rakesh Bam, Ramasamy Paulmurugan

Journal: Sci Rep

PubMed ID: 34845270

Doi: 10.1038/s41598-021-02445-2

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Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

Authors: Aixin Song, Zachary Hazlett, Dulith Abeykoon, Jeremy Dortch, Andrew Dillon, Justin Curtiss, Sarah Bollinger Martinez, Christopher P Hill, Clinton Yu, Lan Huang, David Fushman, Robert E Cohen, Tingting Yao

Journal: Elife

PubMed ID: 34761751

Doi: 10.7554/eLife.72798

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Characterization of a lytic polysaccharide monooxygenase from Aspergillus fumigatus shows functional variation among family AA11 fungal LPMOs

Authors: Fredrik Gjerstad Støpamo, Åsmund Kjendseth Røhr, Sophanit Mekasha, Dejan M Petrović, Anikó Várnai, Vincent G H Eijsink

Journal: J Biol Chem

PubMed ID: 34798071

Doi: 10.1016/j.jbc.2021.101421

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Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex

Authors: Yifan Zhang, Ziyue Chen, Fang Wang, Honghua Sun, Xueliang Zhu, Jianping Ding, Tianlong Zhang

Journal: Structure

PubMed ID: 34793709

Doi: 10.1016/j.str.2021.10.013

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Optimized biosynthesis of santalenes and santalols in Saccharomyces cerevisiae

Authors: Yuchen Wang, Xiaowei Gong, Fan Li, Shasha Zuo, Minggang Li, Jiangyuan Zhao, Xiulin Han, Mengliang Wen

Journal: Appl Microbiol Biotechnol

PubMed ID: 34738171

Doi: 10.1007/s00253-021-11661-9

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Programmable viscoelasticity in protein-RNA condensates with disordered sticker-spacer polypeptides

Authors: Ibraheem Alshareedah, Mahdi Muhammad Moosa, Matthew Pham, Davit A Potoyan, Priya R Banerjee

Journal: Nat Commun

PubMed ID: 34785657

Doi: 10.1038/s41467-021-26733-7

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Authors: Merveille Eguida, Didier Rognan

Journal: J Cheminform

PubMed ID: 34814950

Doi: 10.1186/s13321-021-00567-3

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High SARS-CoV-2 Seroprevalence in Rural Peru, 2021: a Cross-Sectional Population-Based Study

Authors: Andres Moreira-Soto, Johanna Maribel Pachamora Diaz, Lilian González-Auza, Xiomara Jeanleny Merino Merino, Alvaro Schwalb, Christian Drosten, Eduardo Gotuzzo, Michael Talledo, Heriberto Arévalo Ramirez, Roxana Peralta Delgado, Spassky Bocanegra Vargas, Jan Felix Drexler

Journal: mSphere

PubMed ID: 34817236

Doi: 10.1128/mSphere.00685-21

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A novel cytokine consisting of the p40 and EBI3 subunits suppresses experimental autoimmune arthritis via reciprocal regulation of Th17 and Treg cells

Authors: Seon-Yeong Lee, Su-Jin Moon, Young-Mee Moon, Hyeon-Beom Seo, Jun-Geol Ryu, A Ram Lee, Chae Rim Lee, Da-Som Kim, Yang-Mi Her, Jeong Won Choi, Seung-Ki Kwok, Sung-Hwan Park, Mi-La Cho

Journal: Cell Mol Immunol

PubMed ID: 34782759

Doi: 10.1038/s41423-021-00798-2

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A Novel Deoxynivalenol-Activated Wheat Gene Encodes an Antifungal Peptide with Deoxynivalenol Affinity and Protects Plants against Pathogens and Mycotoxins

Authors: Gang Liu, Dong-Yun Zuo, Peng Yang, Wei-Jie He, Zheng Yang, Jing-Bo Zhang, Ai-Bo Wu, Shu-Yuan Yi, He-Ping Li, Tao Huang, Yu-Cai Liao

Journal: J Fungi (Basel)

PubMed ID: 34829228

Doi: 10.3390/jof7110941

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The multicellular signalling network of ovarian cancer metastases

Authors: Leah Sommerfeld, Florian Finkernagel, Julia M Jansen, Uwe Wagner, Andrea Nist, Thorsten Stiewe, Sabine Müller-Brüsselbach, Anna M Sokol, Johannes Graumann, Silke Reinartz, Rolf Müller

Journal: Clin Transl Med

PubMed ID: 34841720

Doi: 10.1002/ctm2.633

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The barley HvSTP13GR mutant triggers resistance against biotrophic fungi

Authors: Caroline Ines Skoppek, Wilko Punt, Marleen Heinrichs, Frank Ordon, Gwendolin Wehner, Jens Boch, Jana Streubel

Journal: Mol Plant Pathol

PubMed ID: 34816582

Doi: 10.1111/mpp.13161

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Influence of flagellin polymorphisms, gene regulation, and responsive memory on the motility of species that cause bacterial spot disease of solanaceous plants

Authors: Maria Laura Malvino, Amie Joy Bott, Cory Edwin Green, Tanvi Majumdar, Sarah Refi Hind

Journal: Mol Plant Microbe Interact

PubMed ID: 34732057

Doi: 10.1094/MPMI-08-21-0211-R

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CLAVATA3 mediated simultaneous control of transcriptional and post-translational processes provides robustness to the WUSCHEL gradient

Authors: Alexander Plong, Kevin Rodriguez, Mark Alber, Weitao Chen, G Venugopala Reddy

Journal: Nat Commun

PubMed ID: 34737298

Doi: 10.1038/s41467-021-26586-0

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The concentration of brain homogenates with the Amicon Ultra Centrifugal filters

Authors: Joshua Yang, Rachita K Sumbria

Journal: MethodsX

PubMed ID: 35004217

Doi: 10.1016/j.mex.2021.101584

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Highly portable quantitative screening test for prostate-specific antigen at point of care

Authors: Balaji Srinivasan, David M Nanus, David Erickson, Saurabh Mehta

Journal: Curr Res Biotechnol

PubMed ID: 35083431

Doi: 10.1016/j.crbiot.2021.11.003

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Performance Characteristics of High-Throughput Serologic Assays for Severe Acute Respiratory Syndrome Coronavirus 2 with Food and Drug Administration Emergency Use Authorization: A Review

Authors:

Journal: Clin Lab Med

PubMed ID: 35153046

Doi: 10.1016/j.cll.2021.10.006

Conservation and Divergence of the Genes Related to Flowering and Circadian Rhythm in

Authors: Yuxi Chen, Rijin Zhou, Qiong Hu, Wenliang Wei, Jia Liu

Journal: Front Plant Sci

PubMed ID: 34880887

Doi: 10.3389/fpls.2021.760379

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Role of cytochrome P450 2C8 genetic polymorphism and epoxygenase uncoupling in periodontal remodelling affecting orthodontic treatment

Authors: Sabrina Yamoune, Katharina Wintz, Christian Niederau, Rogerio B Craveiro, Michael Wolf, Julia Stingl

Journal: Basic Clin Pharmacol Toxicol

PubMed ID: 34740282

Doi: 10.1111/bcpt.13681

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Antibody Generation and Immunogenicity Analysis of EBV gp42 N-Terminal Region

Authors: Junping Hong, Dongmei Wei, Qian Wu, Ling Zhong, Kaiyun Chen, Yang Huang, Wanlin Zhang, Junyu Chen, Ningshao Xia, Xiao Zhang, Yixin Chen

Journal: Viruses

PubMed ID: 34960650

Doi: 10.3390/v13122380

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The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer

Authors: Salomé Adam, Silvia Emma Rossi, Nathalie Moatti, Mara De Marco Zompit, Yibo Xue, Timothy F Ng, Alejandro Álvarez-Quilón, Jessica Desjardins, Vivek Bhaskaran, Giovanni Martino, Dheva Setiaputra, Sylvie M Noordermeer, Toshiro K Ohsumi, Nicole Hustedt, Rachel K Szilard, Natasha Chaudhary, Meagan Munro, Artur Veloso, Henrique Melo, Shou Yun Yin, Robert Papp, Jordan T F Young, Michael Zinda, Manuel Stucki, Daniel Durocher

Journal: Nat Cancer

PubMed ID: 35121901

Doi: 10.1038/s43018-021-00266-w

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A Mycobacteriophage-Based Vaccine Platform: SARS-CoV-2 Antigen Expression and Display

Authors: Krista G Freeman, Katherine S Wetzel, Yu Zhang, Kira M Zack, Deborah Jacobs-Sera, Sara M Walters, Dominique J Barbeau, Anita K McElroy, John V Williams, Graham F Hatfull

Journal: Microorganisms

PubMed ID: 34946016

Doi: 10.3390/microorganisms9122414

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Lipopolysaccharide O-antigen molecular and supramolecular modifications of plant root microbiota are pivotal for host recognition

Authors: Adele Vanacore, Giuseppe Vitiello, Alan Wanke, Domenico Cavasso, Luke A Clifton, Lisa Mahdi, María Asunción Campanero-Rhodes, Dolores Solís, Manfred Wuhrer, Simone Nicolardi, Antonio Molinaro, Roberta Marchetti, Alga Zuccaro, Luigi Paduano, Alba Silipo

Journal: Carbohydr Polym

PubMed ID: 34893256

Doi: 10.1016/j.carbpol.2021.118839

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Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling

Authors: In-Chi Young, Bogang Wu, Jaclyn Andricovich, Sung-Ting Chuang, Rong Li, Alexandros Tzatsos, Ray-Chang Wu, Mei-Yi Wu

Journal: Cell Rep

PubMed ID: 34818550

Doi: 10.1016/j.celrep.2021.110036

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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

Authors: Chensu Wang, Ang Cui, Maurice Bukenya, Aereas Aung, Dikshant Pradhan, Charles A Whittaker, Yash Agarwal, Ayush Thomas, Simon Liang, Parastoo Amlashi, Heikyung Suh, Stefani Spranger, Nir Hacohen, Darrell J Irvine

Journal: Cell Rep

PubMed ID: 34818534

Doi: 10.1016/j.celrep.2021.110021

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