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Efficient acquisition of tens of thousands of short tandem repeats in single-cell whole-genome-amplified DNA

Authors: Liming Tao, Zipora Marx, Ofir Raz, Ehud Shapiro

Journal: STAR Protoc

PubMed ID: 34585162

Doi: 10.1016/j.xpro.2021.100828

Products & Services: Custom DNA/RNA Oligos

A combination of mRNA features influence the efficiency of leaderless mRNA translation initiation

Authors: Mohammed-Husain M Bharmal, Alisa Gega, Jared M Schrader

Journal: NAR Genom Bioinform

PubMed ID: 34568822

Doi: 10.1093/nargab/lqab081

Products & Services: Mutant Libraries

Intrauterine immunizations trigger antigen-specific mucosal and systemic immunity in pigs and passive protection in suckling piglets

Authors: P Choudhary, K R Fourie, S Ng, G Hamonic, N Bérubé, Y Popowych, H L Wilson

Journal: Vaccine

PubMed ID: 34535320

Doi: 10.1016/j.vaccine.2021.08.080

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Wilson WRKY2 Regulates Chitinase Gene Expression During the Response to the Root Rot Pathogen

Authors: Shan Li, Jun Hai, Zie Wang, Jie Deng, Tingting Liang, Linlin Su, Diqiu Liu

Journal: Front Plant Sci

PubMed ID: 34646290

Doi: 10.3389/fpls.2021.741463

Products & Services: Protein Tools

l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters

Authors: Khuong T L Nguyen, Jhih-Yi Chiou, You-Chi Liu, Fang-Ju Cheng, Yi-Cheng Shen, Chao-Jung Chen, Chih-Hsin Tang, Wei-Chien Huang, Chia-Hung Chen, Chih-Yen Tu

Journal: J Cell Physiol

PubMed ID: 34472101

Doi: 10.1002/jcp.30570

Products & Services: Gene Synthesis

LINC01224 promotes colorectal cancer progression through targeting miR-485-5p/MYO6 axis

Authors: Jingfeng Gu, Liang Dong, Yun Wang, Wenjia Nie, Wencong Liu, Ji-An Zhao

Journal: World J Surg Oncol

PubMed ID: 34535152

Doi: 10.1186/s12957-021-02389-x

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Development and Clinical Evaluation of a CRISPR-Based Diagnostic for Rapid Group B Streptococcus Screening

Authors: Lingxiao Jiang, Weiqi Zeng, Wanting Wu, Yingying Deng, Fusheng He, Wenli Liang, Mingyao Huang, Hong Huang, Yongjun Li, Xiaorui Wang, Hang Su, Shilei Pan, Teng Xu

Journal: Emerg Infect Dis

PubMed ID: 34424183

Doi: 10.3201/eid2709.200091

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Poor Neutralizing Antibody Responses in 132 Patients with CLL, NHL and HL after Vaccination against SARS-CoV-2: A Prospective Study

Authors: Evangelos Terpos, Maria Gavriatopoulou, Despina Fotiou, Chara Giatra, Ioannis Asimakopoulos, Maria Dimou, Aimilia D Sklirou, Ioannis Ntanasis-Stathopoulos, Ismini Darmani, Alexandros Briasoulis, Efstathios Kastritis, Maria Angelopoulou, Ioannis Baltadakis, Panayiotis Panayiotidis, Ioannis P Trougakos, Theodoros P Vassilakopoulos, Maria Pagoni, Meletios A Dimopoulos

Journal: Cancers (Basel)

PubMed ID: 34503290

Doi: 10.3390/cancers13174480

Diversity and Evolution of and Transposons in the Apoidea Genomes

Authors: Yibing Liu, Wencheng Zong, Mohamed Diaby, Zheguang Lin, Saisai Wang, Bo Gao, Ting Ji, Chengyi Song

Journal: Biology (Basel)

PubMed ID: 34571816

Doi: 10.3390/biology10090940

Products & Services: Protein Tools

Robust innate responses to SARS-CoV-2 in children resolve faster than in adults without compromising adaptive immunity

Authors: Maria Vono, Angela Huttner, Sylvain Lemeille, Paola Martinez-Murillo, Benjamin Meyer, Stephanie Baggio, Shilpee Sharma, Anais Thiriard, Arnaud Marchant, Gert-Jan Godeke, Chantal Reusken, Catia Alvarez, Francisco Perez-Rodriguez, Isabella Eckerle, Laurent Kaiser, Natasha Loevy, Christiane S Eberhardt, Geraldine Blanchard-Rohner, Claire-Anne Siegrist, Arnaud M Didierlaurent

Journal: Cell Rep

PubMed ID: 34587479

Doi: 10.1016/j.celrep.2021.109773

Developing and characterizing a single-domain antibody (nanobody) against human cytotoxic T-lymphocyte-associated protein 4 (hCTLA-4)

Authors: Nazli Sotoudeh, Zahra Noormohammadi, Mahdi Habibi-Anbouhi, Fatemeh Kazemi-Lomedasht, Mahdi Behdani

Journal: Iran J Basic Med Sci

PubMed ID: 35083014

Doi: 10.22038/IJBMS.2021.57774.12851

Products & Services: DNA Sequencing

Influence of Switchgrass Genes on Vascular Development

Authors: Dongdong Tian, Jingwen Tang, Liwen Luo, Zhe Zhang, Kebing Du, Robert M Larkin, Xueping Shi, Bo Zheng

Journal: Front Plant Sci

PubMed ID: 34630487

Doi: 10.3389/fpls.2021.737219

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Mechanisms of reducing joint stiffness by blocking collagen fibrillogenesis in a rabbit model of posttraumatic arthrofibrosis

Authors: Andrzej Steplewski, Jolanta Fertala, Ryan E Tomlinson, Mark L Wang, Allison Donahue, William V Arnold, Michael Rivlin, Pedro K Beredjiklian, Joseph A Abboud, Surena Namdari, Andrzej Fertala

Journal: PLoS ONE

PubMed ID: 34492074

Doi: 10.1371/journal.pone.0257147

Products & Services: Proteins, Expression, Isolation and Analysis

IgG Antibodies Develop to Spike but Not to the Nucleocapsid Viral Protein in Many Asymptomatic and Light COVID-19 Cases

Authors: Maria Tutukina, Anna Kaznadzey, Maria Kireeva, Ilya Mazo

Journal: Viruses

PubMed ID: 34696374

Doi: 10.3390/v13101945

Products & Services: Mammalian Expression

Functional Characterization of the Cnidarian Antiviral Immune Response Reveals Ancestral Complexity

Authors: Magda Lewandowska, Ton Sharoni, Yael Admoni, Reuven Aharoni, Yehu Moran

Journal: Mol Biol Evol

PubMed ID: 34180999

Doi: 10.1093/molbev/msab197

Products & Services: GenParts™ DNA Fragments

Increase in lamin B1 promotes telomere instability by disrupting the shelterin complex in human cells

Authors: Gaëlle Pennarun, Julien Picotto, Laure Etourneaud, Anna-Rita Redavid, Anaïs Certain, Laurent R Gauthier, Paula Fontanilla-Ramirez, Didier Busso, Caroline Chabance-Okumura, Benoît Thézé, François D Boussin, Pascale Bertrand

Journal: Nucleic Acids Res

PubMed ID: 34469544

Doi: 10.1093/nar/gkab761

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Tumor Microenvironment Responsive Pepper Mild Mottle Virus-Based Nanotubes for Targeted Delivery and Controlled Release of Paclitaxel

Authors: Jiejun Peng, Yueyan Yin, Hongze Liang, Yuwen Lu, Hongying Zheng, Guanwei Wu, Shaofei Rao, Jianping Chen, Fei Yan, Jingbo Hu

Journal: Front Bioeng Biotechnol

PubMed ID: 34660562

Doi: 10.3389/fbioe.2021.763661

Products & Services: Proteins, Expression, Isolation and Analysis

An ultra-sensitive immunoassay detects and quantifies soluble Aβ oligomers in human plasma

Authors: Lei Liu, Hyunchang Kwak, Trebor L Lawton, Shan-Xue Jin, Angela L Meunier, Yifan Dang, Beth Ostaszewski, Alison C Pietras, Andrew M Stern, Dennis J Selkoe

Journal: Alzheimers Dement

PubMed ID: 34550630

Doi: 10.1002/alz.12457

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Direct photoresponsive inhibition of a p53-like transcription activation domain in PIF3 by Arabidopsis phytochrome B

Authors: Chan Yul Yoo, Jiangman He, Qing Sang, Yongjian Qiu, Lingyun Long, Ruth Jean-Ae Kim, Emily G Chong, Joseph Hahm, Nicholas Morffy, Pei Zhou, Lucia C Strader, Akira Nagatani, Beixin Mo, Xuemei Chen, Meng Chen

Journal: Nat Commun

PubMed ID: 34556672

Doi: 10.1038/s41467-021-25909-5

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A morphological transformation in respiratory syncytial virus leads to enhanced complement deposition

Authors: Jessica P Kuppan, Margaret D Mitrovich, Michael D Vahey

Journal: Elife

PubMed ID: 34586067

Doi: 10.7554/eLife.70575

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Immunosuppressed Miniswine as a Model for Testing Cell Therapy Success: Experience With Implants of Human Salivary Stem/Progenitor Cell Constructs

Authors: Danielle Wu, Isabelle M A Lombaert, Maximilien DeLeon, Swati Pradhan-Bhatt, Robert L Witt, Daniel Anton Harrington, Mark G Trombetta, Michael J Passineau, Mary C Farach-Carson

Journal: Front Mol Biosci

PubMed ID: 34660692

Doi: 10.3389/fmolb.2021.711602

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The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway

Authors: Ling Wang, Mary E A Howell, Ayrianna Sparks-Wallace, Juan Zhao, Culton R Hensley, Camri A Nicksic, Shanna R Horne, Kaylea B Mohr, Jonathan P Moorman, Zhi Q Yao, Shunbin Ning

Journal: MBio

PubMed ID: 34488443

Doi: 10.1128/mBio.01097-21

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Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

Authors: Hannah A D King, M Gordon Joyce, Ines Lakhal-Naouar, Aslaa Ahmed, Camila Macedo Cincotta, Caroline Subra, Kristina K Peachman, Holly R Hack, Rita E Chen, Paul V Thomas, Wei-Hung Chen, Rajeshwer S Sankhala, Agnes Hajduczki, Elizabeth J Martinez, Caroline E Peterson, William C Chang, Misook Choe, Clayton Smith, Jarrett A Headley, Hanne A Elyard, Anthony Cook, Alexander Anderson, Kathryn McGuckin Wuertz, Ming Dong, Isabella Swafford, James B Case, Jeffrey R Currier, Kerri G Lal, Mihret F Amare, Vincent Dussupt, Sebastian Molnar, Sharon P Daye, Xiankun Zeng, Erica K Barkei, Kendra Alfson, Hilary M Staples, Ricardo Carrion, Shelly J Krebs, Dominic Paquin-Proulx, Nicos Karasavvas, Victoria R Polonis, Linda L Jagodzinski, Sandhya Vasan, Paul T Scott, Yaoxing Huang, Manoj S Nair, David D Ho, Natalia de Val, Michael S Diamond, Mark G Lewis, Mangala Rao, Gary R Matyas, Gregory D Gromowski, Sheila A Peel, Nelson L Michael, Kayvon Modjarrad, Diane L Bolton

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34470866

Doi: 10.1073/pnas.2106433118

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Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus

Authors: Naglaa Salem El-Sayed, Alexander S Jureka, Megan R Edwards, Sandeep Lohan, Caroline G Williams, Patrick T Keiser, Robert A Davey, Jennifer Totonchy, Rakesh K Tiwari, Christopher F Basler, Keykavous Parang

Journal: Eur J Med Chem

PubMed ID: 34583312

Doi: 10.1016/j.ejmech.2021.113862

Products & Services: Gene Synthesis

BNT162b2 Vaccination Elicits Strong Serological Immune Responses Against SARS-CoV-2 Including Variants of Concern in Elderly Convalescents

Authors: Bernd Jahrsdörfer, Dorit Fabricius, Judith Scholz, Carolin Ludwig, Aline Grempels, Ramin Lotfi, Sixten Körper, Guido Adler, Hubert Schrezenmeier

Journal: Front Immunol

PubMed ID: 34659239

Doi: 10.3389/fimmu.2021.743422

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy

Authors: Lisa M Strong, Chunmei Chang, Julia F Riley, C Alexander Boecker, Thomas G Flower, Cosmo Z Buffalo, Xuefeng Ren, Andrea Kh Stavoe, Erika Lf Holzbaur, James H Hurley

Journal: Elife

PubMed ID: 34505572

Doi: 10.7554/eLife.70372

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Intracellular targeting of Cisd2/Miner1 to the endoplasmic reticulum

Authors: Claudie Bian, Anna Marchetti, Philippe Hammel, Pierre Cosson

Journal: BMC Mol Cell Biol

PubMed ID: 34587896

Doi: 10.1186/s12860-021-00387-1

Products & Services: Proteins, Expression, Isolation and Analysis

Evaluation of a subunit vaccine candidate (Biotech Vac Cox) against Eimeria spp. in broiler chickens

Authors: Emanuel Gumina, Jeffrey W Hall, Bruno Vecchi, Xochitl Hernandez-Velasco, Brett Lumpkins, Greg Mathis, Sherry Layton

Journal: Poultry Science

PubMed ID: 34333387

Doi: 10.1016/j.psj.2021.101329

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Structure-Function Analysis and Redox Interactomes of Leishmania tarentolae Erv

Authors: Gino L Turra, Linda Liedgens, Frederik Sommer, Luzia Schneider, David Zimmer, Jordi Vilurbina Perez, Sasa Koncarevic, Michael Schroda, Timo Mühlhaus, Marcel Deponte

Journal: Microbiol Spectr

PubMed ID: 34585988

Doi: 10.1128/Spectrum.00809-21

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Interactions of ubiquitin and CHMP5 with the V domain of HD-PTP reveals role for regulation of Vps4 ATPase

Authors: Natalya Pashkova, Liping Yu, Nicholas J Schnicker, Chun-Che Tseng, Lokesh Gakhar, David J Katzmann, Robert C Piper

Journal: Mol Biol Cell

PubMed ID: 34586919

Doi: 10.1091/mbc.E21-04-0219

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Function Is More Reliable than Quantity to Follow Up the Humoral Response to the Receptor-Binding Domain of SARS-CoV-2-Spike Protein after Natural Infection or COVID-19 Vaccination

Authors: Carlos A A Sariol, Petraleigh Pantoja, Crisanta Serrano-Collazo, Tiffany Rosa-Arocho, Albersy Armina-Rodríguez, Lorna Cruz, E Taylor Taylor Stone, Teresa Arana, Consuelo Climent, Gerardo Latoni, Dianne Atehortua, Christina Pabon-Carrero, Amelia K K Pinto, James D D Brien, Ana M M Espino

Journal: Viruses

PubMed ID: 34696403

Doi: 10.3390/v13101972

Products & Services: Catalog Antibody

CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle

Authors: Apurva T Prabhakar, Claire D James, Dipon Das, Raymonde Otoa, Matthew Day, John Burgner, Christian T Fontan, Xu Wang, Sarah H Glass, Andreas Wieland, Mary M Donaldson, Molly L Bristol, Renfeng Li, Anthony W Oliver, Laurence H Pearl, Brian O Smith, Iain M Morgan

Journal: MBio

PubMed ID: 34544280

Doi: 10.1128/mBio.01163-21

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A regulatory phosphorylation site on Mec1 controls chromatin occupancy of RNA polymerases during replication stress

Authors: Verena Hurst, Kiran Challa, Felix Jonas, Romain Forey, Ragna Sack, Jan Seebacher, Christoph D Schmid, Naama Barkai, Kenji Shimada, Susan M Gasser, Jérôme Poli

Journal: EMBO J

PubMed ID: 34569643

Doi: 10.15252/embj.2021108439

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Beyond Self-Resistance: ABCF ATPase LmrC Is a Signal-Transducing Component of an Antibiotic-Driven Signaling Cascade Accelerating the Onset of Lincomycin Biosynthesis

Authors: Marketa Koberska, Ludmila Vesela, Vladimir Vimberg, Jakub Lenart, Jana Vesela, Zdenek Kamenik, Jiri Janata, Gabriela Balikova Novotna

Journal: MBio

PubMed ID: 34488446

Doi: 10.1128/mBio.01731-21

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A Neuroprotective Bovine Colostrum Attenuates Apoptosis in Dexamethasone-Treated MC3T3-E1 Osteoblastic Cells

Authors: Sagrario Martin-Aragon, Paloma Bermejo-Bescós, Juana Benedí, Carlos Raposo, Franklim Marques, Eirini K Kydonaki, Paraskevi Gkiata, Yiannis Koutedakis, Georgia Ntina, Andres E Carrillo, Tânia Amorim

Journal: Int J Mol Sci

PubMed ID: 34638536

Doi: 10.3390/ijms221910195

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Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection

Authors: Qibin Geng, Wanbo Tai, Victoria K Baxter, Juan Shi, Yushun Wan, Xiujuan Zhang, Stephanie A Montgomery, Sharon A Taft-Benz, Elizabeth J Anderson, Audrey C Knight, Kenneth H Dinnon, Sarah R Leist, Ralph S Baric, Jian Shang, Sung-Wook Hong, Aleksandra Drelich, Chien-Te K Tseng, Marc Jenkins, Mark Heise, Lanying Du, Fang Li

Journal: PLoS Pathog

PubMed ID: 34492082

Doi: 10.1371/journal.ppat.1009897

Products & Services: Proteins, Expression, Isolation and Analysis

Control of Gene Expression With Quercetin-Responsive Modular Circuits

Authors: Fernanda Miyuki Kashiwagi, Brenno Wendler Miranda, Fabio de Oliveira Pedrosa, Emanuel Maltempi de Souza, Marcelo Müller-Santos

Journal: Front Bioeng Biotechnol

PubMed ID: 34604189

Doi: 10.3389/fbioe.2021.730967

Products & Services: Bacterial Expression

Liquid-liquid phase separation underpins the formation of replication factories in rotaviruses

Authors: Florian Geiger, Julia Acker, Guido Papa, Xinyu Wang, William E Arter, Kadi L Saar, Nadia A Erkamp, Runzhang Qi, Jack Pk Bravo, Sebastian Strauss, Georg Krainer, Oscar R Burrone, Ralf Jungmann, Tuomas Pj Knowles, Hanna Engelke, Alexander Borodavka

Journal: EMBO J

PubMed ID: 34524703

Doi: 10.15252/embj.2021107711

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in Swiss and Dutch Guinea Pigs-Occurrence and Genetic Diversity

Authors: Silvia Ciuria, Michael S M Brouwer, Marende M de Gier, Yvonne van Zeeland, Alex Bossers, Barbara Prähauser, Julia Schädler, Jean-Michel Hatt, Marloes Heijne, Nicole Borel

Journal: Pathogens

PubMed ID: 34684177

Doi: 10.3390/pathogens10101230

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Understanding the Adsorption of Peptides and Proteins onto PEGylated Gold Nanoparticles

Authors: Yasiru Randika Perera, Joanna Xiuzhu Xu, Dhanush L Amarasekara, Alex C Hughes, Ibraheem Abbood, Nicholas C Fitzkee

Journal: Molecules

PubMed ID: 34641335

Doi: 10.3390/molecules26195788

Products & Services: Recombinant Proteins

Transient Electrostatic Interactions between Fcp1 and Rap74 Bias the Conformational Ensemble of the Complex with Minimal Impact on Binding Affinity

Authors: Victor A Prieto, Kevin E W Namitz, Scott A Showalter

Journal: J Phys Chem B

PubMed ID: 34550709

Doi: 10.1021/acs.jpcb.1c05131

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Immunogenicity and potential protection of DNA vaccine of Leishmania martiniquensis against Leishmania infection in mice

Authors: Thuntawat Aunguldee, Orapin Gerdprasert, Piyatida Tangteerawatana, Amporn Jariyapongskul, Saovanee Leelayoova, Benjamas Thanomsub Wongsatayanon

Journal: J Infect Dev Ctries

PubMed ID: 34669604

Doi: 10.3855/jidc.14472

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Lymph Node-Targeted Synthetically Glycosylated Antigen Leads to Antigen-Specific Immunological Tolerance

Authors: Chitavi D Maulloo, Shijie Cao, Elyse A Watkins, Michal M Raczy, Ani S Solanki, Mindy Nguyen, Joseph W Reda, Ha-Na Shim, D Scott Wilson, Melody A Swartz, Jeffrey A Hubbell

Journal: Front Immunol

PubMed ID: 34630389

Doi: 10.3389/fimmu.2021.714842

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Microbial Biosynthesis of L-Malic Acid and Related Metabolic Engineering Strategies: Advances and Prospects

Authors: Zhen Wei, Yongxue Xu, Qing Xu, Wei Cao, He Huang, Hao Liu

Journal: Front Bioeng Biotechnol

PubMed ID: 34660563

Doi: 10.3389/fbioe.2021.765685

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The Isolated in Utero Environment Is Conducive to the Emergence of RNA and DNA Virus Variants

Authors: Daniel Udenze, Ivan Trus, Henry Munyanduki, Nathalie Berube, Uladzimir Karniychuk

Journal: Viruses

PubMed ID: 34578408

Doi: 10.3390/v13091827

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Antibody signatures of asymptomatic Plasmodium falciparum malaria infections measured from dried blood spots

Authors: Christine F Markwalter, Myat Htut Nyunt, Zay Yar Han, Ricardo Henao, Aarti Jain, Omid Taghavian, Philip L Felgner, Kay Thwe Han, Myaing M Nyunt, Christopher V Plowe

Journal: Malar J

PubMed ID: 34556121

Doi: 10.1186/s12936-021-03915-8

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SARS-CoV-2-reactive T-cell receptors isolated from convalescent COVID-19 patients confer potent T-cell effector function

Authors: Fabian Brunk, Andreas Moritz, Annika Nelde, Tatjana Bilich, Nicolas Casadei, Sabine A K Fraschka, Jonas S Heitmann, Sebastian Hörber, Andreas Peter, Hans-Georg Rammensee, Harpreet Singh, Juliane Walz, Dominik Maurer, Claudia Wagner

Journal: Eur J Immunol

PubMed ID: 34424997

Doi: 10.1002/eji.202149290

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APOBEC3C, a nucleolar protein induced by genotoxins, is excluded from DNA damage sites

Authors: Daniel Constantin, Gilles Dubuis, María Del Carmen Conde-Rubio, Christian Widmann

Journal: FEBS J

PubMed ID: 34528388

Doi: 10.1111/febs.16202

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Finding Ways to Relax: A Revisionistic Analysis of the Chemistry of GTP Cyclohydrolase II

Authors: Madison M Smith, Brett A Beaupre, Dariush C Fourozesh, Kathleen M Meneely, Audrey L Lamb, Graham R Moran

Journal: Biochemistry

PubMed ID: 34569786

Doi: 10.1021/acs.biochem.1c00511

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Identifying Distinct Structural Features of the SARS-CoV-2 Spike Protein Fusion Domain Essential for Membrane Interaction

Authors: Daniel Birtles, Jinwoo Lee

Journal: Biochemistry

PubMed ID: 34570469

Doi: 10.1021/acs.biochem.1c00543

Products & Services: Plasmid DNA Preparation