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A Plant-Produced Virus-Like Particle Displaying Envelope Protein Domain III Elicits an Immune Response Against West Nile Virus in Mice

Authors: Jennifer Stander, Aleyo Chabeda, Edward P Rybicki, Ann E Meyers

Journal: Front Plant Sci

PubMed ID: 34589108

Doi: 10.3389/fpls.2021.738619

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Immunoprotection evaluation of the recombinant N-terminal domain of Cys-loop receptors against Rhipicephalus (Boophilus) microplus tick infestation

Authors: Moisés Martínez Velázquez, Carla Patricia Barragán Álvarez, José Miguel Flores Fernández, Rodolfo Esteban Lagunes Quintanilla, Edgar Castro Saines, Patricia Berenice Ramírez Rodríguez, Sara Elisa Herrera Rodríguez, Rodolfo Hernández Gutiérrez, Abel Gutiérrez Ortega, Ángel H Álvarez

Journal: Parasite

PubMed ID: 34533454

Doi: 10.1051/parasite/2021064

Products & Services: Plasmid DNA Preparation

Knockdown of miR‑205‑5p alleviates the inflammatory response in allergic rhinitis by targeting B‑cell lymphoma 6

Authors: Shuang Zhang, Sihan Lin, Qiaofei Tang, Zhiyong Yan

Journal: Mol Med Rep

PubMed ID: 34558634

Doi: 10.3892/mmr.2021.12458

Products & Services: Mutant Libraries

Rapid antibody testing for SARS-CoV-2 vaccine response in pediatric healthcare workers

Authors: Theodore W Heyming, Diane Nugent, Aprille Tongol, Chloe Knudsen-Robbins, Janet Hoang, John Schomberg, Kellie Bacon, Bryan Lara, Terence Sanger

Journal: Int J Infect Dis

PubMed ID: 34601142

Doi: 10.1016/j.ijid.2021.09.065

Products & Services: Proteins, Expression, Isolation and Analysis

Development and characterization of a unique anti-IgE mouse monoclonal antibody cross-reactive between human and canine IgE

Authors: Akiko Kumagai, Takuya Nara, Mizuho Uematsu, Yoko Kakinuma, Takashi Saito, Kenichi Masuda

Journal: Immun Inflamm Dis

PubMed ID: 34533288

Doi: 10.1002/iid3.531

Products & Services: Gene Synthesis

Precise Characterization of Gene Using Cpf1-Based Enrichment and Oxford Nanopore Technologies

Authors: Wei Lu, Xinhui Lan, Tong Zhang, Hao Sun, Sanyuan Ma, Qingyou Xia

Journal: Insects

PubMed ID: 34564273

Doi: 10.3390/insects12090832

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Developing and characterizing a single-domain antibody (nanobody) against human cytotoxic T-lymphocyte-associated protein 4 (hCTLA-4)

Authors: Nazli Sotoudeh, Zahra Noormohammadi, Mahdi Habibi-Anbouhi, Fatemeh Kazemi-Lomedasht, Mahdi Behdani

Journal: Iran J Basic Med Sci

PubMed ID: 35083014

Doi: 10.22038/IJBMS.2021.57774.12851

Products & Services: DNA Sequencing

PEAK1 promotes invasion and metastasis and confers drug resistance in breast cancer

Authors: Xingang Wang, Yan Zheng, Yu Wang

Journal: Clin Exp Med

PubMed ID: 34554318

Doi: 10.1007/s10238-021-00761-5

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A strategy combining 3D-DNA Walker and CRISPR-Cas12a trans-cleavage activity applied to MXene based electrochemiluminescent sensor for SARS-CoV-2 RdRp gene detection

Authors: Kai Zhang, Zhenqiang Fan, Yue Huang, Yuedi Ding, Minhao Xie

Journal: Talanta

PubMed ID: 34635250

Doi: 10.1016/j.talanta.2021.122868

Products & Services: Gene Synthesis

The Novel Nucleoside Analogue ProTide NUC-7738 Overcomes Cancer Resistance Mechanisms and in a First-In-Human Phase I Clinical Trial

Authors: Hagen Schwenzer, Erica De Zan, Mustafa Elshani, Ruud van Stiphout, Mary Kudsy, Josephine Morris, Valentina Ferrari, In Hwa Um, James Chettle, Farasat Kazmi, Leticia Campo, Alistair Easton, Sebastian Nijman, Michaela Serpi, Stefan Symeonides, Ruth Plummer, David J Harrison, Gareth Bond, Sarah P Blagden

Journal: Clin Cancer Res

PubMed ID: 34497073

Doi: 10.1158/1078-0432.CCR-21-1652

Products & Services: Plasmid DNA Preparation

Emergent RNA-RNA interactions can promote stability in a facultative phototrophic endosymbiosis

Authors: Benjamin H Jenkins, Finlay Maguire, Guy Leonard, Joshua D Eaton, Steven West, Benjamin E Housden, David S Milner, Thomas A Richards

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34521754

Doi: 10.1073/pnas.2108874118

Products & Services: Plasmid DNA Preparation

High-Level Expression of Palmitoylated MPP1 Recombinant Protein in Mammalian Cells

Authors: Agnieszka Chytła, Weronika Gajdzik-Nowak, Agnieszka Biernatowska, Aleksander F Sikorski, Aleksander Czogalla

Journal: Membranes (Basel)

PubMed ID: 34564532

Doi: 10.3390/membranes11090715

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Cyclical phosphorylation of LRAP35a and CLASP2 by GSK3β and CK1δ regulates EB1-dependent MT dynamics in cell migration

Authors: Shumei Chia, Thomas Leung, Ivan Tan

Journal: Cell Rep

PubMed ID: 34525355

Doi: 10.1016/j.celrep.2021.109687

Products & Services: Proteins, Expression, Isolation and Analysis

Large chromosomal segment deletions by CRISPR/LbCpf1-mediated multiplex gene editing in soybean

Authors: Kaixuan Duan, Yuanyuan Cheng, Jing Ji, Chenchen Wang, Yongshu Wei, Yuanchao Wang

Journal: J Integr Plant Biol

PubMed ID: 34331750

Doi: 10.1111/jipb.13158

Products & Services: Plasmid DNA Preparation

Transcription factors Krüppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes

Authors: Grzegorz Kotarba, Agnieszka Taracha-Wisniewska, Michal Miller, Michal Dabrowski, Tomasz Wilanowski

Journal: PLoS ONE

PubMed ID: 34570823

Doi: 10.1371/journal.pone.0257977

Products & Services: Plasmid DNA Preparation

Expression, biochemical and structural characterization of high-specific-activity β-amylase from Bacillus aryabhattai GEL-09 for application in starch hydrolysis

Authors: Xuguo Duan, Qiuyu Zhu, Xinyi Zhang, Zhenyan Shen, Yue Huang

Journal: Microb Cell Fact

PubMed ID: 34537082

Doi: 10.1186/s12934-021-01649-5

Products & Services: Plasmid DNA Preparation

Tracing Transmission of Sin Nombre Virus and Discovery of Infection in Multiple Rodent Species

Authors: Samuel M Goodfellow, Robert A Nofchissey, Kurt C Schwalm, Joseph A Cook, Jonathan L Dunnum, Yan Guo, Chunyan Ye, Gregory J Mertz, Kartik Chandran, Michelle Harkins, Daryl B Domman, Darrell L Dinwiddie, Steven B Bradfute

Journal: J Virol

PubMed ID: 34549977

Doi: 10.1128/JVI.01534-21

Products & Services: Plasmid DNA Preparation

The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha

Authors: Martin A Mecchia, Mariano García-Hourquet, Fidel Lozano-Elena, Ainoa Planas-Riverola, David Blasco-Escamez, Mar Marquès-Bueno, Santiago Mora-García, Ana I Caño-Delgado

Journal: Curr Biol

PubMed ID: 34529936

Doi: 10.1016/j.cub.2021.08.050

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Development of High Affinity Calcitonin Analog Fragments Targeting Extracellular Domains of Calcitonin Family Receptors

Authors: Sangmin Lee

Journal: Biomolecules

PubMed ID: 34572577

Doi: 10.3390/biom11091364

Products & Services: Peptide Synthesis

Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations

Authors: Ryuta Baba, Kenji Oki, Celso E Gomez-Sanchez, Yu Otagaki, Kiyotaka Itcho, Kazuhiro Kobuke, Takaya Kodama, Gaku Nagano, Haruya Ohno, Masayasu Yoneda, Noboru Hattori

Journal: Mol Cell Endocrinol

PubMed ID: 34520814

Doi: 10.1016/j.mce.2021.111456

Products & Services: PCR Cloning and Subcloning

Phycobilin heterologous production from the Rhodophyta Porphyridium cruentum

Authors: Erika Juliana Obando Montoya, Sonia Dorion, Lucía Atehortua-Garcés, Jean Rivoal

Journal: J Biotechnol

PubMed ID: 34500003

Doi: 10.1016/j.jbiotec.2021.09.001

Products & Services: PCR Cloning and Subcloning

Genetic Diversity and Population Structure of Affecting Chickpea in Ethiopia

Authors: Gezahegne Getaneh, Tadele Tefera, Fikre Lemessa, Seid Ahmed, Tarekegn Fite, Jandouwe Villinger

Journal: J Fungi (Basel)

PubMed ID: 34682241

Doi: 10.3390/jof7100820

Products & Services: Nucleic Acid Purification & Analysis

Genetic and phenotypic heterogeneity in KIAA0753-related ciliopathies

Authors: Katherine A Inskeep, Yuri A Zarate, Danielle Monteil, Jurgen Spranger, Dan Doherty, Rolf W Stottmann, K Nicole Weaver

Journal: Am J Med Genet A

PubMed ID: 34523780

Doi: 10.1002/ajmg.a.62497

Products & Services: Mutagenesis Services

Development of A Neonatal Mouse Model for Coxsackievirus B1 Antiviral Evaluation

Authors: Zhichao Yin, Yuanyuan Wu, Rui Zhu, Longfa Xu, Yu Lin, Hongwei Yang, Wenkun Fu, Qiongzi Huang, Dongqing Zhang, Jue Wang, Wei Wang, Yingbin Wang, Tong Cheng, Ningshao Xia

Journal: Virol Sin

PubMed ID: 34581960

Doi: 10.1007/s12250-021-00444-1

Products & Services: Monoclonal Antibody Services

Immunological Response Against SARS-COV-2 After BNT162b2 Vaccine Administration Is Impaired in Allogeneic but Not in Autologous Stem Cell Transplant Recipients

Authors: Martina Chiarucci, Sara Paolasini, Alessandro Isidori, Barbara Guiducci, Federica Loscocco, Maria Capalbo, Giuseppe Visani

Journal: Front Oncol

PubMed ID: 34552880

Doi: 10.3389/fonc.2021.737300

Products & Services: Molecular Biology Reagents

Correction to: Quantitative comparison of PD-L1 IHC assays against NIST standard reference material 1934

Authors: Seshi R Sompuram, Emina E Torlakovic, Nils A 't Hart, Kodela Vani, Steven A Bogen

Journal: Mod Pathol

PubMed ID: 34493826

Doi: 10.1038/s41379-021-00898-4

Products & Services: Mammalian Expression

Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine

Authors: Chen Chen, Yoshiaki Yamanaka, Koji Ueda, Peiying Li, Tamami Miyagi, Yuichiro Harada, Sayaka Tezuka, Satoshi Narumi, Masahiro Sugimoto, Masahiko Kuroda, Yuhei Hayamizu, Kohsuke Kanekura

Journal: J Cell Biol

PubMed ID: 34499080

Doi: 10.1083/jcb.202103160

Products & Services: Mammalian Expression

Seroepidemiology of Infection in the General Population of Northern China: The Jidong Community Cohort Study

Authors: Jingwei Shui, Dongjie Xie, Jianhui Zhao, Cailing Ao, Hongqing Lin, Yuanhao Liang, Haiying Wang, Yingchun Dai, Shixing Tang

Journal: Front Microbiol

PubMed ID: 34650533

Doi: 10.3389/fmicb.2021.729016

Products & Services: Mammalian Expression

A bimolecular fluorescence complementation flow cytometry screen for membrane protein interactions

Authors: Florian Schmitz, Jessica Glas, Richard Neutze, Kristina Hedfalk

Journal: Sci Rep

PubMed ID: 34584201

Doi: 10.1038/s41598-021-98810-2

Products & Services: Mammalian Expression

A versatile genetic engineering toolkit for E coli based on CRISPR-prime editing

Authors: Yaojun Tong, Tue S Jørgensen, Christopher M Whitford, Tilmann Weber, Sang Yup Lee

Journal: Nat Commun

PubMed ID: 34471126

Doi: 10.1038/s41467-021-25541-3

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Valorization of lignin components into gallate by integrated biological hydroxylation, O-demethylation, and aryl side-chain oxidation

Authors: Chenggu Cai, Zhaoxian Xu, Huarong Zhou, Sitong Chen, Mingjie Jin

Journal: Sci Adv

PubMed ID: 34516898

Doi: 10.1126/sciadv.abg4585

Products & Services: GenParts™ DNA Fragments

Oriented in situ immobilization of a functional tyrosinase on microcrystalline cellulose effectively incorporates DOPA residues in bioengineered mussel adhesive protein

Authors: Suhyeok Kim, Gaeun Bae, Mincheol Shin, Eungsu Kang, Tae Yoon Park, Yoo Seong Choi, Hyung Joon Cha

Journal: Biotechnol J

PubMed ID: 34536060

Doi: 10.1002/biot.202100216

Products & Services: DNA Sequencing

Location and expression kinetics of Tc24 in different life stages of Trypanosoma cruzi

Authors: Leroy Versteeg, Rakesh Adhikari, Cristina Poveda, Maria Jose Villar-Mondragon, Kathryn M Jones, Peter J Hotez, Maria Elena Bottazzi, Edwin Tijhaar, Jeroen Pollet

Journal: PLoS Negl Trop Dis

PubMed ID: 34478444

Doi: 10.1371/journal.pntd.0009689

Products & Services: DNA Sequencing

Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling

Authors: Taylor P Light, Delphine Brun, Pablo Guardado-Calvo, Riccardo Pederzoli, Ahmed Haouz, Frank Neipel, Félix A Rey, Kalina Hristova, Marija Backovic

Journal: PLoS Biol

PubMed ID: 34499637

Doi: 10.1371/journal.pbio.3001392

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A pH-engineering regenerative DNA tetrahedron ECL biosensor for the assay of SARS-CoV-2 RdRp gene based on CRISPR/Cas12a -activity

Authors: Kai Zhang, Zhenqiang Fan, Yuedi Ding, Minhao Xie

Journal: Chem Eng J

PubMed ID: 34539224

Doi: 10.1016/j.cej.2021.132472

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Visualized Multigene Editing System for

Authors: Cen Li, Jingwen Zhou, Shengqi Rao, Guocheng Du, Song Liu

Journal: ACS Synth Biol

PubMed ID: 34555894

Doi: 10.1021/acssynbio.1c00231

Diversion of metabolic flux towards 5-deoxy(iso)flavonoid production via enzyme self-assembly in

Authors: Jianhua Li, Fanglin Xu, Dongni Ji, Chenfei Tian, Yuwei Sun, Ishmael Mutanda, Yuhong Ren, Yong Wang

Journal: Metab Eng Commun

PubMed ID: 34631421

Doi: 10.1016/j.mec.2021.e00185

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Oral Delivery of Novel Recombinant Elicit High Protection against Pulmonary and Skin Infections

Authors: Na Pan, Bohui Liu, Xuemei Bao, Haochi Zhang, Shouxin Sheng, Yanchen Liang, Haiting Pan, Xiao Wang

Journal: Vaccines (Basel)

PubMed ID: 34579221

Doi: 10.3390/vaccines9090984

Products & Services: Codon Optimization

Metabolic engineering of Deinococcus radiodurans for pinene production from glycerol

Authors: Seyed Hossein Helalat, Carsten Jers, Mandana Bebahani, Hassan Mohabatkar, Ivan Mijakovic

Journal: Microb Cell Fact

PubMed ID: 34565367

Doi: 10.1186/s12934-021-01674-4

Products & Services: Codon Optimization

COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models

Authors: Antonella Conforti, Emanuele Marra, Fabio Palombo, Giuseppe Roscilli, Micol Ravà, Valeria Fumagalli, Alessia Muzi, Mariano Maffei, Laura Luberto, Lucia Lione, Erika Salvatori, Mirco Compagnone, Eleonora Pinto, Emiliano Pavoni, Federica Bucci, Grazia Vitagliano, Daniela Stoppoloni, Maria Lucrezia Pacello, Manuela Cappelletti, Fabiana Fosca Ferrara, Emanuela D'Acunto, Valerio Chiarini, Roberto Arriga, Abraham Nyska, Pietro Di Lucia, Davide Marotta, Elisa Bono, Leonardo Giustini, Eleonora Sala, Chiara Perucchini, Jemma Paterson, Kathryn Ann Ryan, Amy-Rose Challis, Giulia Matusali, Francesca Colavita, Gianfranco Caselli, Elena Criscuolo, Nicola Clementi, Nicasio Mancini, Rüdiger Groß, Alina Seidel, Lukas Wettstein, Jan Münch, Lorena Donnici, Matteo Conti, Raffaele De Francesco, Mirela Kuka, Gennaro Ciliberto, Concetta Castilletti, Maria Rosaria Capobianchi, Giuseppe Ippolito, Luca G Guidotti, Lucio Rovati, Matteo Iannacone, Luigi Aurisicchio

Journal: Mol Ther

PubMed ID: 34547465

Doi: 10.1016/j.ymthe.2021.09.011

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Bispecific Antibody Designed for Targeted NK Cell Activation and Functional Assessment for Biomedical Applications

Authors: Ah-Young Song, Hyori Kim, Jung Min Kim, Sang-Hyun Hwang, Dae-Hyun Ko, Hun Sik Kim

Journal: ACS Appl Mater Interfaces

PubMed ID: 34486371

Doi: 10.1021/acsami.1c08986

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Neuropeptide repertoire and 3D anatomy of the ctenophore nervous system

Authors: Maria Y Sachkova, Eva-Lena Nordmann, Joan J Soto-Àngel, Yasmin Meeda, Bartłomiej Górski, Benjamin Naumann, Daniel Dondorp, Marios Chatzigeorgiou, Maike Kittelmann, Pawel Burkhardt

Journal: Curr Biol

PubMed ID: 34587474

Doi: 10.1016/j.cub.2021.09.005

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Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers

Authors: Tsuguhisa Nakayama, Ivan T Lee, Sizun Jiang, Matthias S Matter, Carol H Yan, Jonathan B Overdevest, Chien-Ting Wu, Yury Goltsev, Liang-Chun Shih, Chun-Kang Liao, Bokai Zhu, Yunhao Bai, Peter Lidsky, Yinghong Xiao, David Zarabanda, Angela Yang, Meena Easwaran, Christian M Schürch, Pauline Chu, Han Chen, Anna K Stalder, David R McIlwain, Nicole A Borchard, Phillip A Gall, Sachi S Dholakia, Wei Le, Le Xu, Chih-Jaan Tai, Te-Huei Yeh, Elizabeth Erickson-Direnzo, Jason M Duran, Kirsten D Mertz, Peter H Hwang, Jasmin D Haslbauer, Peter K Jackson, Thomas Menter, Raul Andino, Peter D Canoll, Adam S DeConde, Zara M Patel, Alexandar Tzankov, Garry P Nolan, Jayakar V Nayak

Journal: Cell Rep Med

PubMed ID: 34604819

Doi: 10.1016/j.xcrm.2021.100421

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Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion

Authors: Jana Škerlová, Jens Berndtsson, Hendrik Nolte, Martin Ott, Pål Stenmark

Journal: Nat Commun

PubMed ID: 34489474

Doi: 10.1038/s41467-021-25570-y

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Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex

Authors: Xi Liu, Laixing Zhang, Yu Xiu, Teng Gao, Ling Huang, Yongchao Xie, Lingguang Yang, Wenhe Wang, Peiyi Wang, Yi Zhang, Maojun Yang, Yue Feng

Journal: Nucleic Acids Res

PubMed ID: 34432044

Doi: 10.1093/nar/gkab738

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Engineering high coenzyme Q tomato

Authors: Hang Fan, Yan Liu, Chen-Yi Li, Yan Jiang, Jiao-Jiao Song, Lei Yang, Qing Zhao, Yong-Hong Hu, Xiao-Ya Chen, Jing-Jing Xu

Journal: Metab Eng

PubMed ID: 34555495

Doi: 10.1016/j.ymben.2021.09.007

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Structural and Kinetic Insights Into the Molecular Basis of Salt Tolerance of the Short-Chain Glucose-6-Phosphate Dehydrogenase From

Authors: Nicolás Fuentes-Ugarte, Sixto M Herrera, Pablo Maturana, Victor Castro-Fernandez, Victoria Guixé

Journal: Front Microbiol

PubMed ID: 34650535

Doi: 10.3389/fmicb.2021.730429

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Azurocidin is loaded into small extracellular vesicles via its N-linked glycosylation and promotes intravasation of renal cell carcinoma cells

Authors: Takuya Naito, Kentaro Jingushi, Koji Ueda, Kazutake Tsujikawa

Journal: FEBS Lett

PubMed ID: 34418081

Doi: 10.1002/1873-3468.14183

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The immunogenomic landscape of resected intrahepatic cholangiocarcinoma

Authors: Fernando Carapeto, Behnaz Bozorgui, Rachna T Shroff, Sharmeen Chagani, Luisa Solis Soto, Wai Chin Foo, Ignacio Wistuba, Funda Meric-Bernstam, Ahmed Shalaby, Milind Javle, Anil Korkut, Lawrence N Kwong

Journal: Hepatology

PubMed ID: 34510503

Doi: 10.1002/hep.32150

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CG Dinucleotide Removal in Bioluminescent and Fluorescent Reporters Improves HIV-1 Replication and Reporter Gene Expression for Dual Imaging in Humanized Mice

Authors: Chandra N Roy, Mariana A Benitez Moreno, Chris Kline, Zandrea Ambrose

Journal: J Virol

PubMed ID: 34232063

Doi: 10.1128/JVI.00449-21

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