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Reprogramming the Biosynthesis of Precursor Peptide to Create a Selenazole-Containing Nosiheptide Analogue

Authors: Yingzi Tan, Miao Wang, Yijun Chen

Journal: ACS Synth Biol

PubMed ID: 35006674

Doi: 10.1021/acssynbio.1c00578

Products & Services: Gene Synthesis

An endogenous bornavirus-like nucleoprotein in miniopterid bats retains the RNA-binding properties of the original viral protein

Authors: Yahiro Mukai, Masayuki Horie, Shohei Kojima, Junna Kawasaki, Ken Maeda, Keizo Tomonaga

Journal: FEBS Lett

PubMed ID: 35043395

Doi: 10.1002/1873-3468.14290

Products & Services: Recombinant Antibody Expression

Anion binding to a cationic europium(III) probe enables the first real-time assay of heparan sulfotransferase activity

Authors: Simon Wheeler, Colum Breen, Yong Li, Sarah H Hewitt, Erin Robertson, Edwin A Yates, Igor L Barsukov, David G Fernig, Stephen J Butler

Journal: Org Biomol Chem

PubMed ID: 34951618

Doi: 10.1039/d1ob02071d

Products & Services: Protein and Antibody Isolation

Expression of phenylalanine ammonia lyases in Synechocystis sp PCC 6803 and subsequent improvements of sustainable production of phenylpropanoids

Authors: Kateryna Kukil, Pia Lindberg

Journal: Microb Cell Fact

PubMed ID: 35012528

Doi: 10.1186/s12934-021-01735-8

Products & Services: Codon Optimization

Genome-wide analysis and transcriptional reprogrammings of MYB superfamily revealed positive insights into abiotic stress responses and anthocyanin accumulation in Carthamus tinctorius L

Authors: Yingqi Hong, Naveed Ahmad, Jianyi Zhang, Yanxi Lv, Xinyue Zhang, Xintong Ma, Liu Xiuming, Yao Na

Journal: Mol Genet Genomics

PubMed ID: 34978004

Doi: 10.1007/s00438-021-01839-1

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Different Functions of , a Drought-Responsive AP2/ERF Transcription Factor, in Regulating Root Development Between and Sweetpotato

Authors: Xiaofeng Bian, Ho Soo Kim, Sang-Soo Kwak, Qian Zhang, Shuai Liu, Peiyong Ma, Zhaodong Jia, Yizhi Xie, Peng Zhang, Yang Yu

Journal: Front Plant Sci

PubMed ID: 35154229

Doi: 10.3389/fpls.2022.820450

Products & Services: Molecular Biology Tools

Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias

Authors: Kouki Kawakami, Masataka Yanagawa, Suzune Hiratsuka, Misaki Yoshida, Yuki Ono, Michio Hiroshima, Masahiro Ueda, Junken Aoki, Yasushi Sako, Asuka Inoue

Journal: Nat Commun

PubMed ID: 35078997

Doi: 10.1038/s41467-022-28056-7

Products & Services: Peptide Synthesis

Comparative Immunogenicity of the Recombinant Receptor-Binding Domain of Protein S SARS-CoV-2 Obtained in Prokaryotic and Mammalian Expression Systems

Authors: Iuliia A Merkuleva, Dmitry N Shcherbakov, Mariya B Borgoyakova, Daniil V Shanshin, Andrey P Rudometov, Larisa I Karpenko, Svetlana V Belenkaya, Anastasiya A Isaeva, Valentina S Nesmeyanova, Elena I Kazachinskaia, Ekaterina A Volosnikova, Tatiana I Esina, Anna V Zaykovskaya, Oleg V Pyankov, Sophia S Borisevich, Arseniya A Shelemba, Anton N Chikaev, Alexander A Ilyichev

Journal: Vaccines (Basel)

PubMed ID: 35062757

Doi: 10.3390/vaccines10010096

Products & Services: Mammalian Expression

SMARCA4 biology in alveolar rhabdomyosarcoma

Authors: Narendra Bharathy, Megan M Cleary, Jin-Ah Kim, Kiyo Nagamori, Kenneth A Crawford, Eric Wang, Debarya Saha, Teagan P Settelmeyer, Reshma Purohit, Damianos Skopelitis, Kenneth Chang, Jessica A Doran, C Ward Kirschbaum, Suriya Bharathy, Davis W Crews, Matthew E Randolph, Anthony N Karnezis, Lisa Hudson-Price, Jyotsna Dhawan, Joel E Michalek, Alessio Ciulli, Christopher R Vakoc, Charles Keller

Journal: Oncogene

PubMed ID: 35094009

Doi: 10.1038/s41388-022-02205-0

Products & Services: Gene Synthesis

Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease

Authors: Lucía Barbier-Torres, Ben Murray, Jin Won Yang, Jiaohong Wang, Michitaka Matsuda, Aaron Robinson, Aleksandra Binek, Wei Fan, David Fernández-Ramos, Fernando Lopitz-Otsoa, Maria Luque-Urbano, Oscar Millet, Nirmala Mavila, Hui Peng, Komal Ramani, Roberta Gottlieb, Zhaoli Sun, Suthat Liangpunsakul, Ekihiro Seki, Jennifer E Van Eyk, Jose M Mato, Shelly C Lu

Journal: Nat Commun

PubMed ID: 35091576

Doi: 10.1038/s41467-022-28201-2

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Structural and biochemical analyses of selectivity determinants in chimeric Streptococcus Class A sortase enzymes

Authors: Melody Gao, D Alex Johnson, Isabel M Piper, Hanna M Kodama, Justin E Svendsen, Elise Tahti, Frederick Longshore-Neate, Brandon Vogel, John M Antos, Jeanine F Amacher

Journal: Protein Sci

PubMed ID: 34939250

Doi: 10.1002/pro.4266

Products & Services: Protein and Antibody Isolation

A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca signalling through IP receptors

Authors: Andrew R Lavik, Karen S McColl, Fernanda O Lemos, Martijn Kerkhofs, Fei Zhong, Michael Harr, Daniela Schlatzer, Kozo Hamada, Katsuhiko Mikoshiba, Francesco Crea, Geert Bultynck, Martin D Bootman, Jan B Parys, Clark W Distelhorst

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 35026348

Doi: 10.1016/j.bbamcr.2021.119206

Products & Services: Peptide Synthesis

MicroRNA analysis reveals the role of miR-214 in duck adipocyte differentiation

Authors: Laidi Wang, Xiaodan Hu, Shasha Wang, Chunyou Yuan, Zhixiu Wang, Guobin Chang, Guohong Chen

Journal: Anim Biosci

PubMed ID: 35073666

Doi: 10.5713/ab.21.0441

Products & Services: Protein and Antibody Isolation

Quantitation of Trastuzumab and an Antibody to SARS-CoV-2 in Minutes Using Affinity Membranes in 96-Well Plates

Authors: Hui Yin Tan, Junyan Yang, Jacqueline C Linnes, Christopher J Welch, Merlin L Bruening

Journal: Anal Chem

PubMed ID: 34982935

Doi: 10.1021/acs.analchem.1c03654

Products & Services: Peptide Synthesis

Development of a radioiodinated thioflavin-T-Congo-red hybrid probe for diagnosis of systemic amyloidosis

Authors: Yoshie Haratake, Kohei Sano, Miki Tsuchiya, Kaori Minaki, Masayuki Munekane, Toshihide Yamasaki, Masayori Hagimori, Takahiro Mukai

Journal: Bioorg Med Chem

PubMed ID: 35033883

Doi: 10.1016/j.bmc.2021.116591

Products & Services: Protein and Antibody Isolation

Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance

Authors: Gabriel Therizols, Zeina Bash-Imam, Baptiste Panthu, Christelle Machon, Anne Vincent, Julie Ripoll, Sophie Nait-Slimane, Mounira Chalabi-Dchar, Angéline Gaucherot, Maxime Garcia, Florian Laforêts, Virginie Marcel, Jihane Boubaker-Vitre, Marie-Ambre Monet, Céline Bouclier, Christophe Vanbelle, Guillaume Souahlia, Elise Berthel, Marie Alexandra Albaret, Hichem C Mertani, Michel Prudhomme, Martin Bertrand, Alexandre David, Jean-Christophe Saurin, Philippe Bouvet, Eric Rivals, Théophile Ohlmann, Jérôme Guitton, Nicole Dalla Venezia, Julie Pannequin, Frédéric Catez, Jean-Jacques Diaz

Journal: Nat Commun

PubMed ID: 35013311

Doi: 10.1038/s41467-021-27847-8

Products & Services: PCR Cloning and Subcloning

CD46 Isoforms Influence the Mode of Entry by Human Herpesvirus 6A/B in T Cells

Authors: Litten Sørensen Rossen, Vivien R Schack, Katrine Kyd Holstein Thuesen, Bettina Bundgaard, Per Höllsberg

Journal: J Virol

PubMed ID: 35019717

Doi: 10.1128/JVI.01557-21

Products & Services: Protein and Antibody Isolation

Whole-genome-scale identification of novel non-protein-coding RNAs controlling cell proliferation and survival through a functional forward genetics strategy

Authors: D P Tonge, D Darling, F Farzaneh, G T Williams

Journal: Sci Rep

PubMed ID: 34997014

Doi: 10.1038/s41598-021-03983-5

Products & Services: Plasmid DNA Preparation

Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2

Authors: Kapil Gupta, Christine Toelzer, Maia Kavanagh Williamson, Deborah K Shoemark, A Sofia F Oliveira, David A Matthews, Abdulaziz Almuqrin, Oskar Staufer, Sathish K N Yadav, Ufuk Borucu, Frederic Garzoni, Daniel Fitzgerald, Joachim Spatz, Adrian J Mulholland, Andrew D Davidson, Christiane Schaffitzel, Imre Berger

Journal: Nat Commun

PubMed ID: 35017512

Doi: 10.1038/s41467-021-27881-6

Products & Services: Plasmid DNA Preparation

Comparison of Carbonic Anhydrases for CO Sequestration

Authors: Franziska Steger, Johanna Reich, Werner Fuchs, Simon K-M R Rittmann, Georg M Gübitz, Doris Ribitsch, Günther Bochmann

Journal: Int J Mol Sci

PubMed ID: 35055147

Doi: 10.3390/ijms23020957

Products & Services: Custom Vector Construction

Efficient and error-free fluorescent gene tagging in human organoids without double-strand DNA cleavage

Authors: Yannik Bollen, Joris H Hageman, Petra van Leenen, Lucca L M Derks, Bas Ponsioen, Julian R Buissant des Amorie, Ingrid Verlaan-Klink, Myrna van den Bos, Leon W M M Terstappen, Ruben van Boxtel, Hugo J G Snippert

Journal: PLoS Biol

PubMed ID: 35089911

Doi: 10.1371/journal.pbio.3001527

Products & Services: Gene Fragments

Humoral Immune Response in IBD Patients Three and Six Months after Vaccination with the SARS-CoV-2 mRNA Vaccines mRNA-1273 and BNT162b2

Authors: Richard Vollenberg, Phil-Robin Tepasse, Joachim Ewald Kühn, Marc Hennies, Markus Strauss, Florian Rennebaum, Tina Schomacher, Göran Boeckel, Eva Lorentzen, Arne Bokemeyer, Tobias Max Nowacki

Journal: Biomedicines

PubMed ID: 35052849

Doi: 10.3390/biomedicines10010171

Ultrasound-mediated gene delivery of factor VIII plasmids for hemophilia A gene therapy in mice

Authors: Shuxian Song, Meghan J Lyle, Misty L Noble-Vranish, Dominic M Min-Tran, James Harrang, Weidong Xiao, Evan C Unger, Carol H Miao

Journal: Mol Ther Nucleic Acids

PubMed ID: 35141050

Doi: 10.1016/j.omtn.2022.01.006

Products & Services: Plasmid DNA Preparation

A mitochondrial ADXR-ADX-P450 electron transport chain is essential for maternal gametophytic control of embryogenesis in

Authors: Andrés Martin Bellido, Ayelén Mariana Distéfano, Nicolás Setzes, María Milagros Cascallares, Jana Oklestkova, Ondrej Novak, Javier Alberto Ramirez, Eduardo J Zabaleta, Diego F Fiol, Gabriela C Pagnussat

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35046016

Doi: 10.1073/pnas.2000482119

Products & Services: Gene Synthesis

Optimization of Thymidine Kinase-Based Safety Switch for Neural Cell Therapy

Authors: Manon Locatelli, Flavien Delhaes, Ophélie Cherpin, Margaret E Black, Stéphanie Carnesecchi, Olivier Preynat-Seauve, Youssef Hibaoui, Karl-Heinz Krause

Journal: Cells

PubMed ID: 35159311

Doi: 10.3390/cells11030502

Products & Services: Codon Optimization

Immunity to Sda1 Protects against Infection by Sda1 and Sda1 Serotypes of Group A

Authors: Shuai Bi, Jie Wang, Meiyi Xu, Ning Li, Beinan Wang

Journal: Vaccines (Basel)

PubMed ID: 35062763

Doi: 10.3390/vaccines10010102

Products & Services: Protein and Antibody Isolation

Alamandine alleviates hypertension and renal damage via oxidative-stress attenuation in Dahl rats

Authors: Juexiao Gong, Man Luo, Yonghong Yong, Shan Zhong, Peng Li

Journal: Cell Death Discov

PubMed ID: 35022384

Doi: 10.1038/s41420-022-00822-y

Products & Services: Custom DNA/RNA Oligos

Time-Prolonged Release of Tumor-Targeted Protein-MMAE Nanoconjugates from Implantable Hybrid Materials

Authors: Naroa Serna, Aïda Falgàs, Annabel García-León, Ugutz Unzueta, Yáiza Núñez, Alejandro Sánchez-Chardi, Carlos Martínez-Torró, Ramón Mangues, Esther Vazquez, Isolda Casanova, Antonio Villaverde

Journal: Pharmaceutics

PubMed ID: 35057088

Doi: 10.3390/pharmaceutics14010192

Products & Services: Protein and Antibody Isolation

BrnQ-Type Branched-Chain Amino Acid Transporters Influence Bacillus anthracis Growth and Virulence

Authors: Soumita Dutta, Ileana D Corsi, Naomi Bier, Theresa M Koehler

Journal: MBio

PubMed ID: 35073743

Doi: 10.1128/mbio.03640-21

Products & Services: Protein and Antibody Isolation

Effects of the Chloroplast Fructose-1,6-Bisphosphate Aldolase Gene on Growth and Low-Temperature Tolerance of Tomato

Authors: Bingbing Cai, Yu Ning, Qiang Li, Qingyun Li, Xizhen Ai

Journal: Int J Mol Sci

PubMed ID: 35054921

Doi: 10.3390/ijms23020728

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Hyperproduction of PHA copolymers containing high fractions of 4-hydroxybutyrate (4HB) by outer membrane-defected Halomonas bluephagenesis grown in bioreactors

Authors: Ziyu Wang, Yifei Zheng, Mengke Ji, Xu Zhang, Huan Wang, Yuemeng Chen, Qiong Wu, Guo-Qiang Chen

Journal: Microb Biotechnol

PubMed ID: 34978757

Doi: 10.1111/1751-7915.13999

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Plant expression systems as an economical alternative for the production of iELISA coating antigen AHSV VP7

Authors: Shelley H Fearon, Susan J Dennis, Inga I Hitzeroth, Edward P Rybicki, Ann E Meyers

Journal: N Biotechnol

PubMed ID: 35114407

Doi: 10.1016/j.nbt.2022.01.009

Products & Services: Gene Synthesis

Zika virus baculovirus-expressed envelope protein elicited humoral and cellular immunity in immunocompetent mice

Authors: Minna Shin, Kiju Kim, Hyo-Ji Lee, Rangyeon Lee, Yu-Jin Jung, Jeongho Park, Tae-Wook Hahn

Journal: Sci Rep

PubMed ID: 35027643

Doi: 10.1038/s41598-021-04713-7

Products & Services: Protein and Antibody Isolation

SNAP23 regulates KCC2 membrane insertion and activity following mZnR/GPR39 activation in hippocampalneurons

Authors: Hila Asraf, Milos Bogdanovic, Noa Gottesman, Israel Sekler, Elias Aizenman, Michal Hershfinkel

Journal: iScience

PubMed ID: 35118363

Doi: 10.1016/j.isci.2022.103751

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Stem-like breast cancer cells in the activated state resist genetic stress via TGFBI-ZEB1

Authors: Qi Sun, Yufen Wang, Adam Officer, Brianna Pecknold, Garrett Lee, Olivier Harismendy, Jay S Desgrosellier

Journal: NPJ Breast Cancer

PubMed ID: 35027548

Doi: 10.1038/s41523-021-00375-w

Products & Services: Plasmid DNA Preparation

Proline-specific aminopeptidase P prevents replication-associated genome instability

Authors: Nicola Silva, Maikel Castellano-Pozo, Kenichiro Matsuzaki, Consuelo Barroso, Monica Roman-Trufero, Hannah Craig, Darren R Brooks, R Elwyn Isaac, Simon J Boulton, Enrique Martinez-Perez

Journal: PLoS Genet

PubMed ID: 35081133

Doi: 10.1371/journal.pgen.1010025

Products & Services: Protein and Antibody Isolation

Precise exogenous insertion and sequence replacements in poplar by simultaneous HDR overexpression and NHEJ suppression using CRISPR-Cas9

Authors: Ali Movahedi, Hui Wei, Xiaohong Zhou, Jake C Fountain, Zhong-Hua Chen, Zhiying Mu, Weibo Sun, Jiaxin Zhang, Dawei Li, Baozhu Guo, Rajeev K Varshney, Liming Yang, Qiang Zhuge

Journal: Hortic Res

PubMed ID: 36133672

Doi: 10.1093/hr/uhac154

Products & Services: Plasmid DNA Preparation

USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma

Authors: Yang Chen, Yin Zhao, Xiaojing Yang, Xianyue Ren, Shengyan Huang, Sha Gong, Xirong Tan, Junyan Li, Shiwei He, Yingqin Li, Xiaohong Hong, Qian Li, Cong Ding, Xueliang Fang, Jun Ma, Na Liu

Journal: Nat Commun

PubMed ID: 35079021

Doi: 10.1038/s41467-022-28158-2

Products & Services: Protein and Antibody Isolation

Omicron infection of vaccinated individuals enhances neutralizing immunity against the Delta variant

Authors: Khadija Khan, Farina Karim, Sandile Cele, James Emmanuel San, Gila Lustig, Houriiyah Tegally, Yuval Rosenberg, Mallory Bernstein, Yashica Ganga, Zesuliwe Jule, Kajal Reedoy, Nokuthula Ngcobo, Yoliswa Miya, Matilda Mazibuko, Ntombifuthi Mthabela, Zoey Mhlane, Nikiwe Mbatha, Jennifer Giandhari, Yajna Ramphal, Taryn Naidoo, Nithendra Manickchund, Nombulelo Magula, Salim Abdool Karim, Glenda Gray, Willem Hanekom, Anne von Gottberg, Ron Milo, Bernadett Gosnell, Richard Lessells, Tulio de Oliveira, Penny Moore, Yunus S Moosa, Alex Sigal

Journal: medrxiv

PubMed ID: 34981076

Doi: 10.1101/2021.12.27.21268439

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Channelopathy-causing mutations in the S45A/S45B and HA/HB helices of KCa2.3 and KCa3.1 channels alter their apparent Ca2+ sensitivity

Authors: Razan Orfali, Young-Woo Nam, Hai Minh Nguyen, Mohammad Asikur Rahman, Grace Yang, Meng Cui, Heike Wulff, Miao Zhang

Journal: Cell Calcium

Doi: doi.org/10.1016/j.ceca.2022.102538

Products & Services: Mutagenesis Services

RBD conjugate vaccine with a built-in TLR1/2 agonist is highly immunogenic against SARS-CoV-2 and variants of concern

Authors: Shi-Hao Zhou 1 , Ru-Yan Zhang, Hai-Wei Zhang, Yan-Ling Liu, Yu Wen, Jian Wang, Yu-Ting Li, Zi-Wei You, Xu-Guang Yin, Hong Qiu, Rui Gong, Guang-Fu Yang, Jun Guo

Journal: Chem Commun (Camb)

PubMed ID: 35040862

Doi: 10.1039/d1cc06520c

Products & Services: Catalog Peptides Catalog Antibodies Recombinant Proteins

A small RNA that cooperatively senses two stacked metabolites in one pocket for gene control

Authors: Griffin M Schroeder, Chapin E Cavender , Maya E Blau, Jermaine L Jenkins, David H Mathews, Joseph E Wedekind

Journal: Nat Commun

PubMed ID: 35017488

Doi: 10.1038/s41467-021-27790-8

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Peptide ligand interaction with maltose-binding protein tagged to the calcitonin gene-related peptide receptor: the inhibitory role of receptor N-glycosylation

Authors: Sangmin Lee

Journal: Peptides

PubMed ID: 35007660

Doi: 10.1016/j.peptides.2022.170735

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Long Non-coding Antisense RNA DDIT4-AS1 Regulates Meningitic Escherichia coli-Induced Neuroinflammation by Promoting DDIT4 mRNA Stability

Authors: Bo Yang, Bojie Xu,Ruicheng Yang, Jiyang Fu, Liang Li, Dong Huo,Jiaqi Chen, Xiaopei Yang,Chen Tan,Huanchun Chen and Xiangru Wang

Journal: Mol Neurobiol

PubMed ID: 34985734

Doi: 10.1007/s12035-021-02690-6

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A VLP-Based Vaccine Candidate Protects Mice against Japanese Encephalitis Virus Infection

Authors: Limin Yang , Aibo Xiao , Hu Wang , Xiaojuan Zhang , Yuan Zhang , Yunlong Li, Yanqiu Wei , Wenjun Liu , Chuangfu Chen

Journal: Vaccines (Basel)

PubMed ID: 35214656

Doi: 10.3390/vaccines10020197

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pVHL-mediated SMAD3 degradation suppresses TGF-β signaling

Authors: Jun Zhou , Yasamin Dabiri , Rodrigo A Gama-Brambila, Shahrouz Ghafoory , Mukaddes Altinbay , Arianeb Mehrabi , Mohammad Golriz , Biljana Blagojevic , Stefanie Reuter , Kang Han , Anna Seidel , Ivan Đikić , Stefan Wölfl , Xinlai Cheng

Journal: J Cell Biol

PubMed ID: 34860252

Doi: 10.1083/jcb.202012097

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Computer-Informed Engineering a New Class I Sesquiterpene Synthase JeSTS4 for the Synthesis of Unusual C10-(S)- Bicyclogermacrene

Authors: Xiaoguang Yan, Jiahui Zhou, Jianjun Ge, Weiguo Li, Dongmei Liang, Warispreet Singh, Gary Black, Shengxin Nie, Jian Liu, Meiqing Sun, Jianjun Qiao, and Meilan Huang

Journal: ACS catalysis

Doi: 10.1021/acscatal.2c00013

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The First FRET-Based RNA Aptamer NanoKit for Sensitively and Specifically Detecting c-di-GMP

Authors: Ya Gao , Yurui Xu , Yanyan Li , Kerong Chen , Xiaotong Wu , Yuhang Liu , Xuli Feng , Desheng Kong , Xinghai Ning

Journal: Nano Lett

PubMed ID: 34994567

Doi: 10.1021/acs.nanolett.1c03970

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A network of Gα signaling partners is revealed by proximity labeling proteomics analysis and includes PDZ-RhoGEF

Authors: Naincy R Chandan, Saji Abraham, Shuvasree SenGupta, Carole A Parent, Alan V Smrcka

Journal: Sci Signal