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A novel chimeric protein with enhanced cytotoxic effects on breast cancer in vitro and in vivo

Authors: Fereshte Hazrati, Massoud Saidijam, Yaghoub Ahmadyousefi, Fatemeh Nouri, Hamidreza Ghadimipour, Mohammadreza Moradi, Rasool Haddadi, Meysam Soleimani

Journal: Proteins

PubMed ID: 34812523

Doi: 10.1002/prot.26285

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Diagnostic Performance of Self-Collected Saliva Versus Nasopharyngeal Swab for the Molecular Detection of SARS-CoV-2 in the Clinical Setting

Authors: Mohammad Khaja Mafij Uddin, Tahmina Shirin, Mohammad Enayet Hossain, Ahmed Nawsher Alam, Jenifar Quaiyum Ami, Rashedul Hasan, Mojnu Miah, Nusrat Jahan Shaly, Shahriar Ahmed, S M Mazidur Rahman, Mustafizur Rahman, Sayera Banu

Journal: Microbiol Spectr

PubMed ID: 34730436

Doi: 10.1128/Spectrum.00468-21

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Identification and evolutionary analysis of the metal-tolerance protein family in eight Cucurbitaceae species

Authors: Xinchen Jiang, Junliang Yin, Lixin Wang, Keyong Xi, Xiongmeng Zhu, Gang Li, Yongxing Zhu, Yiqing Liu

Journal: Plant Genome

PubMed ID: 34741493

Doi: 10.1002/tpg2.20167

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Cofactors and pathogens: Flavin mononucleotide and flavin adenine dinucleotide (FAD) biosynthesis by the FAD synthase from Brucella ovis

Authors: Andrea Moreno, Victor Taleb, María Sebastián, Ernesto Anoz-Carbonell, Marta Martínez-Júlvez, Milagros Medina

Journal: IUBMB Life

PubMed ID: 34813144

Doi: 10.1002/iub.2576

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Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load

Authors: Akihiro Kaneshige, Takayuki Kaji, Lidan Zhang, Hayato Saito, Ayasa Nakamura, Tamaki Kurosawa, Madoka Ikemoto-Uezumi, Kazutake Tsujikawa, Shigeto Seno, Masatoshi Hori, Yasuyuki Saito, Takashi Matozaki, Kazumitsu Maehara, Yasuyuki Ohkawa, Michael Potente, Shuichi Watanabe, Thomas Braun, Akiyoshi Uezumi, So-Ichiro Fukada

Journal: Cell Stem Cell

PubMed ID: 34856120

Doi: 10.1016/j.stem.2021.11.003

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The circular RNA circSLC7A11 functions as a mir-330-3p sponge to accelerate hepatocellular carcinoma progression by regulating cyclin-dependent kinase 1 expression

Authors: Yu Huang, Wenhao Ge, Yuan Ding, Lufei Zhang, Jiarong Zhou, Yang Kong, Bijun Cui, Bingqiang Gao, Xiaohui Qian, Weilin Wang

Journal: Cancer Cell Int

PubMed ID: 34844614

Doi: 10.1186/s12935-021-02351-7

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TAL effector-dependent Bax gene expression in transgenic rice confers disease resistance to Xanthomonas oryzae pv oryzae

Authors: Yuejing Gui, Dongsheng Tian, Kar Hui Ong, Joanne Chin Yi Teo, Zhongchao Yin

Journal: Transgenic Res

PubMed ID: 34748132

Doi: 10.1007/s11248-021-00290-7

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A super PPR cluster for restoring fertility revealed by genetic mapping, homocap-seq and de novo assembly in cotton

Authors: Bin Gao, Gaofeng Ren, Tianwang Wen, Haiping Li, Xianlong Zhang, Zhongxu Lin

Journal: Theor Appl Genet

PubMed ID: 34811574

Doi: 10.1007/s00122-021-03990-0

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An allergen-fused dendritic cell-binding peptide enhances in vitro proliferation of equine T-cells and cytokine production

Authors: Anja Ziegler, Judith Olzhausen, Eman Hamza, Ana Stojiljkovic, Michael H Stoffel, Mattia Garbani, Claudio Rhyner, Eliane Marti

Journal: Vet Immunol Immunopathol

PubMed ID: 34800874

Doi: 10.1016/j.vetimm.2021.110351

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Positively Regulates Pepper Immunity by Targeting against Inoculation through Modulating Defense-Related Genes

Authors: Ansar Hussain, Muhammad Ifnan Khan, Mohammed Albaqami, Shahzadi Mahpara, Ijaz Rasool Noorka, Mohamed A A Ahmed, Bandar S Aljuaid, Ahmed M El-Shehawi, Zhiqin Liu, Shahid Farooq, Ali Tan Kee Zuan

Journal: Int J Mol Sci

PubMed ID: 34769521

Doi: 10.3390/ijms222112091

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Mt10-CVB3 Vaccine Virus Protects against CVB4 Infection by Inducing Cross-Reactive, Antigen-Specific Immune Responses

Authors: Ninaad Lasrado, Rajkumar Arumugam, Mahima T Rasquinha, Meghna Sur, David Steffen, Jay Reddy

Journal: Microorganisms

PubMed ID: 34835449

Doi: 10.3390/microorganisms9112323

Products & Services: Proteins, Expression, Isolation and Analysis

The pleiotropic functions of intracellular hydrophobins in aerial hyphae and fungal spores

Authors: Feng Cai, Zheng Zhao, Renwei Gao, Peijie Chen, Mingyue Ding, Siqi Jiang, Zhifei Fu, Pingyong Xu, Komal Chenthamara, Qirong Shen, Günseli Bayram Akcapinar, Irina S Druzhinina

Journal: PLoS Genet

PubMed ID: 34788288

Doi: 10.1371/journal.pgen.1009924

Products & Services: Proteins, Expression, Isolation and Analysis

A conserved guided entry of tail-anchored pathway is involved in the trafficking of a subset of membrane proteins in Plasmodium falciparum

Authors: Tarkeshwar Kumar, Satarupa Maitra, Abdur Rahman, Souvik Bhattacharjee

Journal: PLoS Pathog

PubMed ID: 34780541

Doi: 10.1371/journal.ppat.1009595

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The synaptic scaffolding protein CNKSR2 interacts with CYTH2 to mediate hippocampal granule cell development

Authors: Hidenori Ito, Rika Morishita, Mariko Noda, Tomoki Ishiguro, Masashi Nishikawa, Koh-Ichi Nagata

Journal: J Biol Chem

PubMed ID: 34800437

Doi: 10.1016/j.jbc.2021.101427

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Microinjection of pruritogens in NGF-sensitized human skin

Authors: Hans Jürgen Solinski, Roman Rukwied, Martin Schmelz

Journal: Sci Rep

PubMed ID: 34728705

Doi: 10.1038/s41598-021-00935-x

Products & Services: Proteins, Expression, Isolation and Analysis

A feminizing switch in a hemimetabolous insect

Authors: Ji-Chong Zhuo , Hou-Hong Zhang , Qing-Ling Hu , Jin-Li Zhang , Jia-Bao Lu , Han-Jing Li , Yu-Cheng Xie , Wei-Wei Wang , Yan Zhang , Hai-Qiang Wang , Hai-Jian Huang , Gang Lu , Jian-Ping Chen , Jun-Min Li , Zhi-Jian Tu , Chuan-Xi Zhang

Journal: Sci Adv

PubMed ID: 34826246

Doi: 10.1126/sciadv.abf9237

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A novel effector, CsSp1, from Bipolaris sorokiniana, is essential for colonization in wheat and is also involved in triggering host immunity

Authors: Wanying Zhang, Haiyang Li, Limin Wang, Shunpei Xie, Yuan Zhang, Ruijiao Kang, Mengjuan Zhang, Panpan Zhang, Yonghui Li, Yanfeng Hu, Min Wang, Linlin Chen, Hongxia Yuan, Shengli Ding, Honglian Li

Journal: Mol Plant Pathol

PubMed ID: 34741560

Doi: 10.1111/mpp.13155

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DNA Matrix Operation Based on the Mechanism of the DNAzyme Binding to Auxiliary Strands to Cleave the Substrate

Authors: Shaoxia Xu, Yuan Liu, Shihua Zhou, Qiang Zhang, Nikola K Kasabov

Journal: Biomolecules

PubMed ID: 34944442

Doi: 10.3390/biom11121797

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Lipopolysaccharide O-antigen molecular and supramolecular modifications of plant root microbiota are pivotal for host recognition

Authors: Adele Vanacore, Giuseppe Vitiello, Alan Wanke, Domenico Cavasso, Luke A Clifton, Lisa Mahdi, María Asunción Campanero-Rhodes, Dolores Solís, Manfred Wuhrer, Simone Nicolardi, Antonio Molinaro, Roberta Marchetti, Alga Zuccaro, Luigi Paduano, Alba Silipo

Journal: Carbohydr Polym

PubMed ID: 34893256

Doi: 10.1016/j.carbpol.2021.118839

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Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases

Authors: Zhirong Fu, Srinivas Akula, Anna-Karin Olsson, Jukka Kervinen, Lars Hellman

Journal: Int J Mol Sci

PubMed ID: 34884431

Doi: 10.3390/ijms222312627

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Patterns of Tetracapsuloides bryosalmonae infection of three salmonid species in large, deep Norwegian lakes

Authors: Tone Jøran Oredalen, Mona Saebø, Tor Atle Mo

Journal: J Fish Dis

PubMed ID: 34747501

Doi: 10.1111/jfd.13548

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Nanovesicles derived from bispecific CAR-T cells targeting the spike protein of SARS-CoV-2 for treating COVID-19

Authors: Tianchuan Zhu, Yuchen Xiao, Xiaojun Meng, Lantian Tang, Bin Li, Zhaoyan Zhao, Qingqin Tan, Hong Shan, Lei Liu, Xi Huang

Journal: J Nanobiotechnology

PubMed ID: 34823562

Doi: 10.1186/s12951-021-01148-0

Products & Services: Proteins, Expression, Isolation and Analysis

The Excretory/Secretory and Surface Proteome Contains Putative Modulators of the Host Coagulation

Authors: Nina Gillis-Germitsch, Tobias Kockmann, Lars M Asmis, Lucienne Tritten, Manuela Schnyder

Journal: Front Cell Infect Microbiol

PubMed ID: 34796127

Doi: 10.3389/fcimb.2021.753320

Products & Services: Proteins, Expression, Isolation and Analysis

Epitope-coated polymer particles elicit neutralising antibodies against Plasmodium falciparum sporozoites

Authors: Benjamin J Evert, Shuxiong Chen, Robyn McConville, Ryan W J Steel, Julie Healer, Justin A Boddey, Lucas Huntimer, Bernd H A Rehm

Journal: npj Vaccines

PubMed ID: 34845267

Doi: 10.1038/s41541-021-00408-2

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Proliferation of Tau 304-380 Fragment Aggregates through Autocatalytic Secondary Nucleation

Authors: Diana C Rodriguez Camargo, Eimantas Sileikis, Sean Chia, Emil Axell, Katja Bernfur, Rodrigo L Cataldi, Samuel I A Cohen, Georg Meisl, Johnny Habchi, Tuomas P J Knowles, Michele Vendruscolo, Sara Linse

Journal: ACS Chem Neurosci

PubMed ID: 34783519

Doi: 10.1021/acschemneuro.1c00454

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High-throughput and high-dimensional single-cell analysis of antigen-specific CD8 T cells

Authors: Ke-Yue Ma, Alexandra A Schonnesen, Chenfeng He, Amanda Y Xia, Eric Sun, Eunise Chen, Katherine R Sebastian, Yu-Wan Guo, Robert Balderas, Mrinalini Kulkarni-Date, Ning Jiang

Journal: Nat Immunol

PubMed ID: 34811538

Doi: 10.1038/s41590-021-01073-2

Products & Services: Proteins, Expression, Isolation and Analysis

Assessment of an LSDV-Vectored Vaccine for Heterologous Prime-Boost Immunizations against HIV

Authors: Ros Chapman, Michiel van Diepen, Nicola Douglass, Shireen Galant, Mohamed Jaffer, Emmanuel Margolin, Phindile Ximba, Tandile Hermanus, Penny L Moore, Anna-Lise Williamson

Journal: Vaccines (Basel)

PubMed ID: 34835214

Doi: 10.3390/vaccines9111281

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Acute myeloid leukemia cell membrane-coated nanoparticles for cancer vaccination immunotherapy

Authors: Daniel T Johnson, Jiarong Zhou, Ashley V Kroll, Ronnie H Fang, Ming Yan, Crystal Xiao, Xiufen Chen, Justin Kline, Liangfang Zhang, Dong-Er Zhang

Journal: Leukemia

PubMed ID: 34845316

Doi: 10.1038/s41375-021-01432-w

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Scaling DNA data storage with nanoscale electrode wells

Authors: Bichlien H Nguyen, Christopher N Takahashi, Gagan Gupta, Jake A Smith, Richard Rouse, Paul Berndt, Sergey Yekhanin, David P Ward, Siena D Ang, Patrick Garvan, Hsing-Yeh Parker, Rob Carlson, Douglas Carmean, Luis Ceze, Karin Strauss

Journal: Sci Adv

PubMed ID: 34818035

Doi: 10.1126/sciadv.abi6714

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Construction of an enzyme-based all-fiber SPR biosensor for detection of enantiomers

Authors: Zhuoyue Zhou, Zhao Yang, Li Xia, Houjin Zhang

Journal: Biosens Bioelectron

PubMed ID: 34847363

Doi: 10.1016/j.bios.2021.113836

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Characterization of Anti-Ana o 3 Monoclonal Antibodies and Their Application in Comparing Brazilian Cashew Cultivars

Authors: Christopher P Mattison, Barry Vant-Hull, Ana Cecilia Ribeiro de Castro, Heidi J Chial, Yvette Bren-Mattison, Peter J Bechtel, Edy Sousa de Brito

Journal: Antibodies (Basel)

PubMed ID: 34939998

Doi: 10.3390/antib10040046

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Evaluation of the Immune Response of a Candidate Phage-Based Vaccine against (Cattle Tick)

Authors: Alejandro González-Mora, Kenny Misael Calvillo-Rodríguez, Jesús Hernández-Pérez, Marco Rito-Palomares, Ana Carolina Martínez-Torres, Jorge Benavides

Journal: Pharmaceutics

PubMed ID: 34959300

Doi: 10.3390/pharmaceutics13122018

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Performance Characteristics of High-Throughput Serologic Assays for Severe Acute Respiratory Syndrome Coronavirus 2 with Food and Drug Administration Emergency Use Authorization: A Review

Authors:

Journal: Clin Lab Med

PubMed ID: 35153046

Doi: 10.1016/j.cll.2021.10.006

Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release

Authors: Wanqiu Li, Linlin Wang, Bradley M. Wierbowski, Mo Lu, Feitong Dong, Wenchen Liu, Sisi Li, Peiyi Wang, Adrian Salic, Xin Gong

Journal: Nature Communications

Doi: doi.org/10.1038/s41467-021-27257-w

Products & Services: Proteins, Expression, Isolation and Analysis

Conservation and Divergence of the Genes Related to Flowering and Circadian Rhythm in

Authors: Yuxi Chen, Rijin Zhou, Qiong Hu, Wenliang Wei, Jia Liu

Journal: Front Plant Sci

PubMed ID: 34880887

Doi: 10.3389/fpls.2021.760379

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Fecal microbiota changes in NZB/W F1 mice after induction of lupus disease

Authors: Yen-Fu Chen, Ao-Ho Hsieh, Lian-Chin Wang, Yun-Ju Huang, Wen-Yi Tseng, Yu-Lun Kuo, Shue-Fen Luo, Kuang-Hui Yu, Chang-Fu Kuo

Journal: Sci Rep

PubMed ID: 34824318

Doi: 10.1038/s41598-021-02422-9

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Interaction of Copper Trafficking Proteins with the Platinum Anticancer Drug Kiteplatin

Authors: Alessandra Barbanente, Angela Galliani, Rosa Maria Iacobazzi, Alessia Lasorsa, Maria Incoronata Nardella, Antonio Pennetta, Nicola Margiotta, Fabio Arnesano

Journal: ChemMedChem

PubMed ID: 34727402

Doi: 10.1002/cmdc.202100593

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Boosting BCG with recombinant influenza A virus tuberculosis vaccines increases pulmonary T cell responses but not protection against Mycobacterium tuberculosis infection

Authors: Heni Muflihah, Manuela Flórido, Leon C W Lin, Yingju Xia, James A Triccas, John Stambas, Warwick J Britton

Journal: PLoS ONE

PubMed ID: 34793507

Doi: 10.1371/journal.pone.0259829

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Improved Sensitivity of Allergen Detection by Immunoaffinity LC-MS/MS Using Ovalbumin as a Case Study

Authors: Martin Röder, Claudia Wiacek, Frauke Lankamp, Jonathan Kreyer, Wolfgang Weber, Elke Ueberham

Journal: Foods

PubMed ID: 34945483

Doi: 10.3390/foods10122932

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ILC3s control airway inflammation by limiting T cell responses to allergens and microbes

Authors: Fei Teng, Roser Tachó-Piñot, Biin Sung, Donna L Farber, Stefan Worgall, Hamida Hammad, Bart N Lambrecht, Matthew R Hepworth, Gregory F Sonnenberg

Journal: Cell Rep

PubMed ID: 34818549

Doi: 10.1016/j.celrep.2021.110051

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Unveiling mRNP composition by fluorescence correlation and cross-correlation spectroscopy using cell lysates

Authors: Àngels Mateu-Regué, Jan Christiansen, Frederik Otzen Bagger, Christian Hellriegel, Finn Cilius Nielsen

Journal: Nucleic Acids Res

PubMed ID: 34478550

Doi: 10.1093/nar/gkab751

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Nogo receptor impairs the clearance of fibril amyloid-β by microglia and accelerates Alzheimer's-like disease progression

Authors: Jianing Wang, Xiaoying Qin, Hao Sun, Meijun He, Qunyu Lv, Congcong Gao, Xinran He, Hong Liao

Journal: Aging Cell

PubMed ID: 34821024

Doi: 10.1111/acel.13515

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Spike residue 403 affects binding of coronavirus spikes to human ACE2

Authors: Fabian Zech, Daniel Schniertshauer, Christoph Jung, Alexandra Herrmann, Arne Cordsmeier, Qinya Xie, Rayhane Nchioua, Caterina Prelli Bozzo, Meta Volcic, Lennart Koepke, Janis A Müller, Jana Krüger, Sandra Heller, Steffen Stenger, Markus Hoffmann, Stefan Pöhlmann, Alexander Kleger, Timo Jacob, Karl-Klaus Conzelmann, Armin Ensser, Konstantin M J Sparrer, Frank Kirchhoff

Journal: Nat Commun

PubMed ID: 34824253

Doi: 10.1038/s41467-021-27180-0

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Immune reactivity and host modulatory roles of two novel Haemonchus contortus cathepsin B-like proteases

Authors: Mariam Bakshi, Wenbin Tuo, Raffi V Aroian, Dante Zarlenga

Journal: Parasit Vectors

PubMed ID: 34798906

Doi: 10.1186/s13071-021-05010-y

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Piwi4 Structural Features Are Necessary for RNA Binding and Nuclear Localization

Authors: Adeline E Williams, Gaurav Shrivastava, Apostolos G Gittis, Sundar Ganesan, Ines Martin-Martin, Paola Carolina Valenzuela Leon, Ken E Olson, Eric Calvo

Journal: Int J Mol Sci

PubMed ID: 34884537

Doi: 10.3390/ijms222312733

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Gain of Spontaneous Mutations Boosting Motility Adaption to Environments in

Authors: Bingyu Li, Chaofan Hou, Xian Ju, Yong Feng, Zhi-Qiang Ye, Yunzhu Xiao, Mingyao Gu, Chunxiang Fu, Chaoliang Wei, Conghui You

Journal: Front Bioeng Biotechnol

PubMed ID: 34900963

Doi: 10.3389/fbioe.2021.772397

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G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators

Authors: Malarvizhi Gurusamy, Denise Tischner, Jingchen Shao, Stephan Klatt, Sven Zukunft, Remy Bonnavion, Stefan Günther, Kai Siebenbrodt, Roxane-Isabelle Kestner, Tanja Kuhlmann, Ingrid Fleming, Stefan Offermanns, Nina Wettschureck

Journal: Nat Commun

PubMed ID: 34815397

Doi: 10.1038/s41467-021-26882-9

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TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9

Authors: Jinming Zhao, Yan Xiu, Lin Fu, Qianze Dong, Nicholas Borcherding, Yang Wang, Qingchang Li, Nilushi S De Silva, Ulf Klein, Brendan F Boyce, Chen Zhao

Journal: iScience

PubMed ID: 34877491

Doi: 10.1016/j.isci.2021.103425

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Curcumol inhibits malignant biological behaviors and TMZ-resistance in glioma cells by inhibiting long noncoding RNA FOXD2-As1-promoted EZH2 activation

Authors: Xuyang Lv, Jiangchuan Sun, Linfeng Hu, Ying Qian, Chunlei Fan, Nan Tian

Journal: Aging (Albany NY)

PubMed ID: 34739394

Doi: 10.18632/aging.203662

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Plant LHC-like proteins show robust folding and static non-photochemical quenching

Authors: Petra Skotnicová, Hristina Staleva-Musto, Valentyna Kuznetsova, David Bína, Minna M Konert, Shan Lu, Tomáš Polívka, Roman Sobotka

Journal: Nat Commun

PubMed ID: 34824207

Doi: 10.1038/s41467-021-27155-1

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