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In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins

Authors: Jérôme Montnach, Laila Ananda Blömer, Ludivine Lopez, Luiza Filipis, Hervé Meudal, Aude Lafoux, Sébastien Nicolas, Duong Chu, Cécile Caumes, Rémy Béroud, Chris Jopling, Frank Bosmans, Corinne Huchet, Céline Landon, Marco Canepari, Michel De Waard

Journal: Nat Commun

PubMed ID: 35058427

Doi: 10.1038/s41467-022-27974-w

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Predictive Factors for Neutralizing Antibody Levels Nine Months after Full Vaccination with BNT162b2: Results of a Machine Learning Analysis

Authors: Dimitris Papadopoulos, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Zoi Evangelakou, Panagiotis Malandrakis, Maria S Manola, Despoina D Gianniou, Efstathios Kastritis, Ioannis P Trougakos, Meletios A Dimopoulos, Vangelis Karalis, Evangelos Terpos

Journal: Biomedicines

PubMed ID: 35203412

Doi: 10.3390/biomedicines10020204

A biomimetic enzyme-linked immunosorbent assay (BELISA) for the analysis of gonadorelin by using molecularly imprinted polymer-coated microplates

Authors: Francesca Torrini, Laura Caponi, Andrea Bertolini, Pasquale Palladino, Francesca Cipolli, Alessandro Saba, Aldo Paolicchi, Simona Scarano, Maria Minunni

Journal: Anal Bioanal Chem

PubMed ID: 35028691

Doi: 10.1007/s00216-021-03867-7

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Ethylene response factor MdERF4 and histone deacetylase MdHDA19 suppress apple fruit ripening through histone deacetylation of ripening related genes

Authors: Yanan Hu, Zhenyun Han, Ting Wang, Hua Li, Qiqi Li, Shuai Wang, Ji Tian, Yi Wang, Xinzhong Zhang, Xuefeng Xu, Zhenhai Han, Peitao Lü, Ting Wu

Journal: Plant Physiol

PubMed ID: 35088866

Doi: 10.1093/plphys/kiac016

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Speed dating for enzymes! Finding the perfect phosphopantetheinyl transferase partner for your polyketide synthase

Authors: Tobias Bruun Pedersen, Mikkel Rank Nielsen, Sebastian Birkedal Kristensen, Eva Mie Lang Spedtsberg, Trine Sørensen, Celine Petersen, Jens Muff, Teis Esben Sondergaard, Kåre Lehmann Nielsen, Reinhard Wimmer, Donald Max Gardiner, Jens Laurids Sørensen

Journal: Microb Cell Fact

PubMed ID: 35012550

Doi: 10.1186/s12934-021-01734-9

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Initiator-Directed Transcription: Fission Yeast Nmtl Initiator Directs Preinitiation Complex Formation and Transcriptional Initiation

Authors: Diego A Rojas, Fabiola Urbina, Lucía Valenzuela-Pérez, Lorenzo Leiva, Vicente J Miralles, Edio Maldonado

Journal: Genes (Basel)

PubMed ID: 35205301

Doi: 10.3390/genes13020256

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Authors: Xiaohui Yuan, Han Xue, Xiaomeng Xu, Xinan Jiao, Zhiming Pan, Yunzeng Zhang

Journal: Gut Pathog

PubMed ID: 35078518

Doi: 10.1186/s13099-022-00480-6

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Augmented ERAD (ER-associated degradation) activity in chondrocytes is necessary for cartilage development and maintenance

Authors: Hyo Jung Sim, Chanmi Cho, Ha Eun Kim, Ju Yeon Hong, Eun Kyung Song, Keun Yeong Kwon, Dong Gil Jang, Seok-Jung Kim, Hyun-Shik Lee, Changwook Lee, Taejoon Kwon, Siyoung Yang, Tae Joo Park

Journal: Sci Adv

PubMed ID: 35061535

Doi: 10.1126/sciadv.abl4222

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FACI Is a Novel CREB-H-Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity

Authors: Yun Cheng, Xiao-Zhuo Kang, Tao Cheng, Zi-Wei Ye, George L Tipoe, Cheng-Han Yu, Chi-Ming Wong, Baohua Liu, Chi-Ping Chan, Dong-Yan Jin

Journal: Cell Mol Gastroenterol Hepatol

PubMed ID: 35093589

Doi: 10.1016/j.jcmgh.2022.01.017

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The Impact of Tyrosine Iodination on the Aggregation and Cleavage Kinetics of MMP-9-Responsive Peptide Sequences

Authors: Douglas S MacPherson, Scott A McPhee, Brian M Zeglis, Rein V Ulijn

Journal: ACS Biomater Sci Eng

PubMed ID: 35050574

Doi: 10.1021/acsbiomaterials.1c01488

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Novel Neutralizing Epitope of PEDV S1 Protein Identified by IgM Monoclonal Antibody

Authors: Techit Thavorasak, Monrat Chulanetra, Kittirat Glab-Ampai, Karsidete Teeranitayatarn, Thaweesak Songserm, Rungrueang Yodsheewan, Nawannaporn Sae-Lim, Porntippa Lekcharoensuk, Nitat Sookrung, Wanpen Chaicumpa

Journal: Viruses

PubMed ID: 35062329

Doi: 10.3390/v14010125

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Anticancer Vaccination with Immunogenic Micelles That Capture and Release Pristine CD8 T-Cell Epitopes and Adjuvants

Authors: He Ren, Jiexin Li, Gengqi Liu, Yaping Sun, Xingyue Yang, Zhen Jiang, Jingyu Zhang, Jonathan F Lovell, Yumiao Zhang

Journal: ACS Appl Mater Interfaces

PubMed ID: 34986639

Doi: 10.1021/acsami.1c18117

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NanoBRET in C elegans illuminates functional receptor interactions in real time

Authors: Victoria Elisabeth Groß, Miron Mikhailowitsch Gershkovich, Torsten Schöneberg, Anette Kaiser, Simone Prömel

Journal: BMC Mol Cell Biol

PubMed ID: 35100990

Doi: 10.1186/s12860-022-00405-w

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Directed Evolution of Replication-Competent Double-Stranded DNA Bacteriophage toward New Host Specificity

Authors: Jing Liang, Huibin Zhang, Yee Ling Tan, Huimin Zhao, Ee Lui Ang

Journal: ACS Synth Biol

PubMed ID: 35090114

Doi: 10.1021/acssynbio.1c00319

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The CinB Nuclease from No Is Sufficient for Induction of Cytoplasmic Incompatibility in

Authors: Guangxin Sun, Mengwen Zhang, Hongli Chen, Mark Hochstrasser

Journal: MBio

PubMed ID: 35073749

Doi: 10.1128/mbio.03177-21

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Evidence for the Rapid and Divergent Evolution of Mycoplasmas: Structural and Phylogenetic Analysis of Enolases

Authors: Rong Chen, Lin Zhao, Rong Gan, Zhixin Feng, Chenxi Cui, Xing Xie, Fei Hao, Zhenzhen Zhang, Li Wang, Tingting Ran, Weiwu Wang, Shuijun Zhang, Yufeng Li, Wei Zhang, Maoda Pang, Qiyan Xiong, Guoqing Shao

Journal: Front Mol Biosci

PubMed ID: 35145997

Doi: 10.3389/fmolb.2021.811106

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Orthogonal proteomics methods to unravel the HOTAIR interactome

Authors: Louis Delhaye, Edith De Bruycker, Pieter-Jan Volders, Daria Fijalkowska, Delphine De Sutter, Sven Degroeve, Lennart Martens, Pieter Mestdagh, Sven Eyckerman

Journal: Sci Rep

PubMed ID: 35087108

Doi: 10.1038/s41598-022-05405-6

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A De Novo Optimized Cell-Free System for the Expression of Soluble and Active Human Tumor Necrosis Factor-Alpha

Authors: Nawal Abd El-Baky, Esmail M El-Fakharany, Soraya A Sabry, Ehab R El-Helow, Elrashdy Mustafa Redwan, Amira Sabry

Journal: Biology (Basel)

PubMed ID: 35205024

Doi: 10.3390/biology11020157

Products & Services: Mammalian Expression

Double nicking by RNA-directed Cascade-nCas3 for high-efficiency large-scale genome engineering

Authors: Yile Hao, Qinhua Wang, Jie Li, Shihui Yang, Yanli Zheng, Wenfang Peng

Journal: Open Biol

PubMed ID: 35016549

Doi: 10.1098/rsob.210241

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Protection of Mice against Experimental Cryptococcosis by Synthesized Peptides Delivered in Glucan Particles

Authors: Charles A Specht, E Jane Homan, Chrono K Lee, Zhongming Mou, Christina L Gomez, Maureen M Hester, Ambily Abraham, Florentina Rus, Gary R Ostroff, Stuart M Levitz

Journal: MBio

PubMed ID: 35089095

Doi: 10.1128/mbio.03367-21

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Transcriptome analysis of Leucojum aestivum and identification of genes involved in norbelladine biosynthesis

Authors: Laurence Tousignant, Aracely Maribel Diaz-Garza, Bharat Bhusan Majhi, Sarah-Eve Gélinas, Aparna Singh, Isabel Desgagne-Penix

Journal: Planta

PubMed ID: 34981205

Doi: 10.1007/s00425-021-03741-x

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Identification and characterization of natural PR-1 protein as major allergen from Humulus japonicus pollen

Authors: Ye Wang, Ling-Xiao Tan, Zhi-Qiang Xu, Yong-Xin Jiao, Dan-Xuan Zhu, Yong-Shi Yang, Ji-Fu Wei, Jin-Lyu Sun, Man Tian

Journal: Mol Immunol

PubMed ID: 36525884

Doi: 10.1016/j.molimm.2022.11.023

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A NR2E1-interacting peptide of LSD1 inhibits the proliferation of brain tumour initiating cells

Authors: Rong Hu, Umar Farook Shahul Hameed, Xiang Sun, Balakrishnan Shenbaga Moorthy, Wen Zhang, Philip D Jeffrey, Li Zhou, Xin Ma, Fangjin Chen, Jianfeng Pei, Pankaj K Giri, Yonggao Mou, Kunchithapadam Swaminathan, Ping Yuan

Journal: Cell Prolif

PubMed ID: 36321378

Doi: 10.1111/cpr.13350

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Surveillance of emerging infectious diseases for biosecurity

Authors: Rongzhang Hao, Yuqi Liu, Wanzhu Shen, Rongtao Zhao, Bo Jiang, Hongbin Song, Muyang Yan, Hui Ma

Journal: Sci China Life Sci

PubMed ID: 35287183

Doi: 10.1007/s11427-021-2071-x

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Tongxinluo prevents chronic obstructive pulmonary disease complicated with atherosclerosis by inhibiting ferroptosis and protecting against pulmonary microvascular barrier dysfunction

Authors: Yafen Wang, Xiangnan Kuang, Yujie Yin , Ningxin Han, Liping Chang, Hongtao Wang, Yunlong Hou, Huixin Li, Zhen Li , Yi Liu, Yuanjie Hao , Yaru Wei, Xiaoqi Wang, Zhenhua Jia

Journal: Biomed Pharmacother

PubMed ID: 34740097

Doi: 10.1016/j.biopha.2021.112367

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T cell responses to SARS-CoV-2 spike cross-recognize Omicron

Authors: Roanne Keeton, Marius B Tincho, Amkele Ngomti, Richard Baguma, Ntombi Benede, Akiko Suzuki, Khadija Khan, Sandile Cele, Mallory Bernstein, Farina Karim, Sharon V Madzorera, Thandeka Moyo-Gwete, Mathilda Mennen, Sango Skelem, Marguerite Adriaanse, Daniel Mutithu, Olukayode Aremu, Cari Stek, Elsa du Bruyn, Mieke A Van Der Mescht, Zelda de Beer, Talita R de Villiers, Annie Bodenstein, Gretha van den Berg, Adriano Mendes, Amy Strydom, Marietjie Venter, Jennifer Giandhari, Yeshnee Naidoo, Sureshnee Pillay, Houriiyah Tegally, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Robert J Wilkinson, Tulio de Oliveira, Linda-Gail Bekker, Glenda Gray, Veronica Ueckermann, Theresa Rossouw, Michael T Boswell, Jinal N Bhiman, Penny L Moore, Alex Sigal, Ntobeko A B Ntusi, Wendy A Burgers, Catherine Riou

Journal: Nature

PubMed ID: 35102311

Doi: 10.1038/s41586-022-04460-3

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Shoc2 recognizes bacterial flagellin and mediates antibacterial Erk/Stat signaling in an invertebrate

Authors: Bao-Rui Zhao, Xin-Xin Wang, Xian-Wei Wang

Journal: PLoS Pathog

PubMed ID: 35073369

Doi: 10.1371/journal.ppat.1010253

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Engineered human antibodies for the opsonization and killing of

Authors: Xinhai Chen, Olaf Schneewind, Dominique Missiakas

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35058363

Doi: 10.1073/pnas.2114478119

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Porcine TRIM21 Enhances Porcine Circovirus 2 Infection and Host Immune Responses, But Inhibits Apoptosis of PCV2-Infected Cells

Authors: Lin Yang, Xiaohua Liu, Liying Zhang, Xue Li, Xinwei Zhang, Guoyu Niu, Weilong Ji, Si Chen, Hongsheng Ouyang, Linzhu Ren

Journal: Viruses

PubMed ID: 35062360

Doi: 10.3390/v14010156

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Targeted gene silencing in the nervous system with CRISPR-Cas13

Authors: Jackson E Powell, Colin K W Lim, Ramya Krishnan, Tristan X McCallister, Christian Saporito-Magriña, Maria A Zeballos, Garrett D McPheron, Thomas Gaj

Journal: Sci Adv

PubMed ID: 35044815

Doi: 10.1126/sciadv.abk2485

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Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants

Authors: Anna Goc, Aleksandra Niedzwiecki, Vadim Ivanov, Svetlana Ivanova, Matthias Rath

Journal: Eur J Microbiol Immunol (Bp)

PubMed ID: 35060921

Doi: 10.1556/1886.2021.00022

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High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD)

Authors: Shohei Beppu, Makoto Kinoshita, Jan Wilamowski, Tadahiro Suenaga, Yoshiaki Yasumizu, Kotaro Ogawa, Teruyuki Ishikura, Satoru Tada, Toru Koda, Hisashi Murata, Naoyuki Shiraishi, Yasuko Sugiyama, Keigo Kihara, Tomoyuki Sugimoto, Hisashi Arase, Daron M Standley, Tatsusada Okuno, Hideki Mochizuki

Journal: Sci Rep

PubMed ID: 34997058

Doi: 10.1038/s41598-021-04074-1

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The temporal gene expression profiles of calcium and phosphorus transporters in Hy-Line Brown layers

Authors: Xiaojuan Wang, Peng Li, Jingpeng Zhao, Hongchao Jiao, Hai Lin

Journal: Poult Sci

PubMed ID: 35202896

Doi: 10.1016/j.psj.2022.101736

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SARS-CoV-2 NSP13 Inhibits Type I IFN Production by Degradation of TBK1 via p62-Dependent Selective Autophagy

Authors: Chao Sui, Tongyang Xiao, Shengyuan Zhang, Hongxiang Zeng, Yi Zheng, Bingyu Liu, Gang Xu, Chengjiang Gao, Zheng Zhang

Journal: J Immunol

PubMed ID: 34996837

Doi: 10.4049/jimmunol.2100684

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Two phylogenetically unrelated peptide-receptor modules jointly regulate lateral root initiation via a partially shared signaling pathway in Arabidopsis thaliana

Authors: Joris Jourquin, Ana Ibis Fernandez, Boris Parizot, Ke Xu, Wim Grunewald, Akihito Mamiya, Hidehiro Fukaki, Tom Beeckman

Journal: New Phytol

PubMed ID: 34913488

Doi: 10.1111/nph.17919

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Kinetics and persistence of cellular and humoral immune responses to SARS-CoV-2 vaccine in healthcare workers with or without prior COVID-19

Authors: Mihaela Chivu-Economescu, Coralia Bleotu, Camelia Grancea, Daniela Chiriac, Anca Botezatu, Iulia V Iancu, Ioana Pitica, Laura G Necula, Ana Neagu, Lilia Matei, Denisa Dragu, Camelia Sultana, Elena L Radu, Alina Nastasie, Oana Voicu, Marius Ataman, Saviana Nedeianu, Cristina Mambet, Carmen C Diaconu, Simona Maria Ruta

Journal: J Cell Mol Med

PubMed ID: 35043552

Doi: 10.1111/jcmm.17186

The H, N and C resonance assignments of the low-complexity domain from the oncogenic fusion protein EWS-FLI1

Authors: Courtney N Johnson, Xiaoping Xu, Stephen P Holloway, David S Libich

Journal: Biomol NMR Assign

PubMed ID: 34994941

Doi: 10.1007/s12104-021-10061-4

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Genome-Wide Identification and Expression Profiles of Genes in L

Authors: Meng Lu, Xiang-Xiao Meng, Yi-Ming Zhang, Xue-Wen Zhu, Jun Li, Wei-Qiang Chen, Hui-Hua Wan, Si-Fan Wang, Xue Cao, Wei Sun, Yao-Lei Mi, Jun-Wen Zhai

Journal: Cannabis Cannabinoid Res

PubMed ID: 35020417

Doi: 10.1089/can.2021.0153

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Hemagglutinin-based DNA vaccines containing trimeric self-assembling nanoparticles confer protection against influenza

Authors: Yongbo Qiao, Shenghui Jin, Jiaojiao Nie, Yaotian Chang, Bo Wang, Shanshan Guan, Qinghan Li, Yuhua Shi, Wei Kong, Yaming Shan

Journal: J Leukoc Biol

PubMed ID: 35040188

Doi: 10.1002/JLB.6A1021-535R

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A phage parasite deploys a nicking nuclease effector to inhibit viral host replication

Authors: Kristen N LeGault, Zachary K Barth, Peter DePaola, Kimberley D Seed

Journal: Nucleic Acids Res

PubMed ID: 35066583

Doi: 10.1093/nar/gkac002

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Preparation and characterization of 2-deacetyl-3-O-sulfo-heparosan and its antitumor effects via the fibroblast growth factor receptor pathway

Authors: Zhengqi Zha, Yaoyao Liu, Yinghua Miao, Shiying Liao, Su-Yan Wang, Huiling Tang, Hongping Yin

Journal: Int J Biol Macromol

PubMed ID: 34998873

Doi: 10.1016/j.ijbiomac.2021.12.098

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Inhibition of microRNA-448 suppresses CD4 T cell inflammatory activation via up-regulating suppressor of cytokine signaling 5 in systemic lupus erythematosus

Authors: Jing Zhang, Yun Guo, Yue Sun, Lihua Chang, Xiaofei Wang

Journal: Biochem Biophys Res Commun

PubMed ID: 35121374

Doi: 10.1016/j.bbrc.2022.01.097

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NCAPH promotes cell proliferation and inhibits cell apoptosis of bladder cancer cells through MEK/ERK signaling pathway

Authors: Bo Li, Qian Xiao, Liping Shan, Yongsheng Song

Journal: Cell Cycle

PubMed ID: 34974790

Doi: 10.1080/15384101.2021.2021050

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Involvement of β-cyanoalanine synthase (β-CAS) and sulfurtransferase (ST) in cyanide (CN) assimilation in rice seedlings

Authors: Yu-Xi Feng, Cheng-Zhi Li, Yu-Juan Lin, Xiao-Zhang Yu

Journal: Chemosphere

PubMed ID: 35101430

Doi: 10.1016/j.chemosphere.2022.133789

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Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers

Authors: Hanna Klingel, Maike Lauen, Alexander Krüttgen, Matthias Imöhl, Michael Kleines

Journal: Clin Exp Vaccine Res

PubMed ID: 35223673

Doi: 10.7774/cevr.2022.11.1.121

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Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor

Authors: Jinliang Wang, Jie Luo, Zhiyuan Wen, Xinxin Wang, Lei Shuai, Gongxun Zhong, Chong Wang, Ziruo Sun, Weiye Chen, Jinying Ge, Renqiang Liu, Xijun Wang, Zhigao Bu

Journal: MBio

PubMed ID: 35012335

Doi: 10.1128/mbio.02443-21

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Efficacy of an ALDH peptide-based dendritic cell vaccine targeting cancer stem cells

Authors: Fei Liao, Jing Zhang, Yangyang Hu, Alireza Hassani Najafabadi, James J Moon, Max S Wicha, Bashir Kaspo, Joel Whitfield, Alfred E Chang, Qiao Li

Journal: Cancer Immunol Immunother

PubMed ID: 35098344

Doi: 10.1007/s00262-021-03129-6

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An Active Peptide-Based Packaging System to Improve the Freshness and Safety of Fish Products: A Case Study

Authors: Rosa Luisa Ambrosio, Marta Gogliettino, Bruna Agrillo, Yolande T R Proroga, Marco Balestrieri, Lorena Gratino, Daniela Cristiano, Gianna Palmieri, Aniello Anastasio

Journal: Foods

PubMed ID: 35159493

Doi: 10.3390/foods11030338

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miR-223 in exosomes from bone marrow mesenchymal stem cells ameliorates rheumatoid arthritis via downregulation of NLRP3 expression in macrophages

Authors: Ying Huang, Daomin Lu, Wukai Ma, Jun Liu, Qiaoyi Ning, Fang Tang, Long Li

Journal: Mol Immunol

PubMed ID: 35042119

Doi: 10.1016/j.molimm.2022.01.002

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Novel Function of Avian p53 in Binding to ALV-J LTR Contributes to Its Antiviral Roles

Authors: Yueyue Duan, Liyan Cao, Cong Yuan, Xuepeng Suo, Xiangyu Kong, Yulong Gao, Xiangtong Li, Haixue Zheng, Xiaomei Wang, Qi Wang

Journal: MBio

PubMed ID: 35038897

Doi: 10.1128/mbio.03287-21

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