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Mitochondrial Localization Signal of Porcine Circovirus Type 2 Capsid Protein Plays a Critical Role in Cap-Induced Apoptosis

Authors: Wanting Yu, Yuao Sun, Qing He, Chaoying Sun, Tian Dong, Luhua Zhang, Yang Zhan, Naidong Wang, Yi Yang, Yujie Sun

Journal: Vet Sci

PubMed ID: 34822645

Doi: 10.3390/vetsci8110272

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Optimized biosynthesis of santalenes and santalols in Saccharomyces cerevisiae

Authors: Yuchen Wang, Xiaowei Gong, Fan Li, Shasha Zuo, Minggang Li, Jiangyuan Zhao, Xiulin Han, Mengliang Wen

Journal: Appl Microbiol Biotechnol

PubMed ID: 34738171

Doi: 10.1007/s00253-021-11661-9

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Programmable viscoelasticity in protein-RNA condensates with disordered sticker-spacer polypeptides

Authors: Ibraheem Alshareedah, Mahdi Muhammad Moosa, Matthew Pham, Davit A Potoyan, Priya R Banerjee

Journal: Nat Commun

PubMed ID: 34785657

Doi: 10.1038/s41467-021-26733-7

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Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

Authors: Aixin Song, Zachary Hazlett, Dulith Abeykoon, Jeremy Dortch, Andrew Dillon, Justin Curtiss, Sarah Bollinger Martinez, Christopher P Hill, Clinton Yu, Lan Huang, David Fushman, Robert E Cohen, Tingting Yao

Journal: Elife

PubMed ID: 34761751

Doi: 10.7554/eLife.72798

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of a lytic polysaccharide monooxygenase from Aspergillus fumigatus shows functional variation among family AA11 fungal LPMOs

Authors: Fredrik Gjerstad Støpamo, Åsmund Kjendseth Røhr, Sophanit Mekasha, Dejan M Petrović, Anikó Várnai, Vincent G H Eijsink

Journal: J Biol Chem

PubMed ID: 34798071

Doi: 10.1016/j.jbc.2021.101421

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Recombinant Human HPS Protects Mice and Nonhuman Primates from Acute Liver Injury

Authors: Yang Yang, Huali Zhai, Yue Wan, Xiaofang Wang, Hui Chen, Lihou Dong, Taoyun Liu, Guifang Dou, Chutse Wu, Miao Yu

Journal: Int J Mol Sci

PubMed ID: 34884691

Doi: 10.3390/ijms222312886

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Expression and purification of a native Thy1-single-chain variable fragment for use in molecular imaging

Authors: Natacha Jugniot, Rakesh Bam, Ramasamy Paulmurugan

Journal: Sci Rep

PubMed ID: 34845270

Doi: 10.1038/s41598-021-02445-2

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Diacylglycerol kinase A is essential for polymyxin resistance provided by EptA, MCR-1 and other lipid A phosphoethanolamine transferases

Authors: Alexandria B Purcell, Bradley J Voss, M Stephen Trent

Journal: J Bacteriol

PubMed ID: 34843376

Doi: 10.1128/JB.00498-21

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Comparative proteomics reveals Cryptosporidium parvum manipulation of the host cell molecular expression and immune response

Authors: Teng Li, Hua Liu, Nan Jiang, Yiluo Wang, Ying Wang, Jing Zhang, Yujuan Shen, Jianping Cao

Journal: PLoS Negl Trop Dis

PubMed ID: 34818332

Doi: 10.1371/journal.pntd.0009949

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Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex

Authors: Yifan Zhang, Ziyue Chen, Fang Wang, Honghua Sun, Xueliang Zhu, Jianping Ding, Tianlong Zhang

Journal: Structure

PubMed ID: 34793709

Doi: 10.1016/j.str.2021.10.013

Products & Services: Proteins, Expression, Isolation and Analysis

Gasdermin D inhibition confers antineutrophil mediated cardioprotection in acute myocardial infarction

Authors: Kai Jiang, Zizhuo Tu, Kun Chen, Yue Xu, Feng Chen, Sheng Xu, Tingting Shi, Jie Qian, Lan Shen, John Hwa, Dandan Wang, Yaozu Xiang

Journal: J Clin Invest

PubMed ID: 34752417

Doi: 10.1172/JCI151268

Products & Services: Proteins, Expression, Isolation and Analysis

Highly portable quantitative screening test for prostate-specific antigen at point of care

Authors: Balaji Srinivasan, David M Nanus, David Erickson, Saurabh Mehta

Journal: Curr Res Biotechnol

PubMed ID: 35083431

Doi: 10.1016/j.crbiot.2021.11.003

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Performance Characteristics of High-Throughput Serologic Assays for Severe Acute Respiratory Syndrome Coronavirus 2 with Food and Drug Administration Emergency Use Authorization: A Review

Authors:

Journal: Clin Lab Med

PubMed ID: 35153046

Doi: 10.1016/j.cll.2021.10.006

Piezo2 mechanosensitive ion channel is located to sensory neurons and nonneuronal cells in rat peripheral sensory pathway: implications in pain

Authors: Seung Min Shin, Francie Moehring, Brandon Itson-Zoske, Fan Fan, Cheryl L Stucky, Quinn H Hogan, Hongwei Yu

Journal: Pain

PubMed ID: 34285153

Doi: 10.1097/j.pain.0000000000002356

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Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

Authors: Mohamad-Gabriel Alameh, István Tombácz, Emily Bettini, Katlyn Lederer, Chutamath Sittplangkoon, Joel R Wilmore, Brian T Gaudette, Ousamah Y Soliman, Matthew Pine, Philip Hicks, Tomaz B Manzoni, James J Knox, John L Johnson, Dorottya Laczkó, Hiromi Muramatsu, Benjamin Davis, Wenzhao Meng, Aaron M Rosenfeld, Shirin Strohmeier, Paulo J C Lin, Barbara L Mui, Ying K Tam, Katalin Karikó, Alain Jacquet, Florian Krammer, Paul Bates, Michael P Cancro, Drew Weissman, Eline T Luning Prak, David Allman, Michela Locci, Norbert Pardi

Journal: Immunity

PubMed ID: 34852217

Doi: 10.1016/j.immuni.2021.11.001

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Refinement and Neutralization Evaluation of the F(ab') Type of Antivenom against the Deadly Jellyfish Toxins

Authors: Rongfeng Li, Huahua Yu, Aoyu Li, Chunlin Yu, Pengcheng Li

Journal: Int J Mol Sci

PubMed ID: 34884477

Doi: 10.3390/ijms222312672

Products & Services: Proteins, Expression, Isolation and Analysis

Role of cytochrome P450 2C8 genetic polymorphism and epoxygenase uncoupling in periodontal remodelling affecting orthodontic treatment

Authors: Sabrina Yamoune, Katharina Wintz, Christian Niederau, Rogerio B Craveiro, Michael Wolf, Julia Stingl

Journal: Basic Clin Pharmacol Toxicol

PubMed ID: 34740282

Doi: 10.1111/bcpt.13681

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Endotoxin Acts Synergistically With Clostridioides difficile Toxin B to Increase Interleukin 1β Production: A Potential Role for the Intestinal Biome in Modifying the Severity of C difficile Colitis

Authors: Pyae Htwe, Htay Aung, Bohm Kywe, Phyu T Niang, Thar Sann Oo, Sindhu Monhandas, Libusha Kelly, David L Goldman

Journal: J Infect Dis

PubMed ID: 33780547

Doi: 10.1093/infdis/jiab165

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Modified cyclodextrin-based nanoparticles mediated delivery of siRNA for huntingtin gene silencing across an in vitro BBB model

Authors: Monique C P Mendonça, Michael F Cronin, John F Cryan, Caitriona M O'Driscoll

Journal: Eur J Pharm Biopharm

PubMed ID: 34793942

Doi: 10.1016/j.ejpb.2021.11.003

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Potential role of BAY11-7082, a NF-κB blocker inhibiting experimental autoimmune encephalomyelitis in C57BL/6J mice via declining NLRP3 inflammasomes

Authors: Yue Lang, Fengna Chu, Lingling Liu, Chao Zheng, Chunrong Li, Donghui Shen, Shan Liu, Weiguanliu Zhang, Li Cui, Jie Zhu

Journal: Clin Exp Immunol

PubMed ID: 35020839

Doi: 10.1093/cei/uxab022

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TGF-β1-overexpressing mesenchymal stem cells reciprocally regulate Th17/Treg cells by regulating the expression of IFN-γ

Authors: Ruixue Li, Renyong Wang, Shijie Zhong, Farhan Asghar, Tiehan Li, Lei Zhu, Hong Zhu

Journal: Open Life Sci

PubMed ID: 34761110

Doi: 10.1515/biol-2021-0118

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Structure-based engineering of an antiangiogenic scFv antibody for soluble production in E coli without loss of activity

Authors: Melis Denizci Öncü, Bertan Koray Balcıoğlu, Beytullah Özgür, Hasan Ümit Öztürk, Müge Serhatlı, Şeyma Işık, Berrin Erdağ, Gizem Dinler Doğanay, Aylin Özdemir Bahadır

Journal: Biotechnol Appl Biochem

PubMed ID: 34694021

Doi: 10.1002/bab.2273

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Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling

Authors: Anna Spier, Michael G Connor, Thomas Steiner, Filipe Carvalho, Pascale Cossart, Wolfgang Eisenreich, Timothy Wai, Fabrizia Stavru

Journal: Cell Rep

PubMed ID: 34758302

Doi: 10.1016/j.celrep.2021.109989

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Quantitative contributions of TNF receptor superfamily members to CD8 T-cell responses

Authors: John Nguyen, Johannes Pettmann, Philipp Kruger, Omer Dushek

Journal: Mol Syst Biol

PubMed ID: 34806839

Doi: 10.15252/msb.202110560

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Accelerated discovery of novel glycoside hydrolases using targeted functional profiling and selective pressure on the rumen microbiome

Authors: André L A Neves, Jiangkun Yu, Yutaka Suzuki, Marisol Baez-Magana, Elena Arutyunova, Eóin O'Hara, Tim McAllister, Kim H Ominski, M Joanne Lemieux, Le Luo Guan

Journal: Microbiome

PubMed ID: 34814938

Doi: 10.1186/s40168-021-01147-1

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CD4+ effector T cells accelerate Alzheimer's disease in mice

Authors: Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L Namminga, Katherine E Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y Poluektova, Channabasavaiah B Gurumurthy, R Lee Mosley, Howard E Gendelman

Journal: J Neuroinflammation

PubMed ID: 34798897

Doi: 10.1186/s12974-021-02308-7

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Long noncoding RNA CRART16 confers 5-FU resistance in colorectal cancer cells by sponging miR-193b-5p

Authors: Jingui Wang, Xiaoqian Zhang, Junling Zhang, Shangwen Chen, Jing Zhu, Xin Wang

Journal: Cancer Cell Int

PubMed ID: 34844630

Doi: 10.1186/s12935-021-02353-5

Products & Services: Proteins, Expression, Isolation and Analysis

Calcium-Responsive Diguanylate Cyclase CasA Drives Cellulose-Dependent Biofilm Formation and Inhibits Motility in Vibrio fischeri

Authors: Alice H Tischler, Michael E Vanek, Natasha Peterson, Karen L Visick

Journal: MBio

PubMed ID: 34749532

Doi: 10.1128/mBio.02573-21

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Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation

Authors: Elie Hammam, Ameya Sinha, Sebastian Baumgarten, Flore Nardella, Jiaqi Liang, Samia Miled, Frédéric Bonhomme, Diane Erdmann, Benoit Arcangioli, Paola B Arimondo, Peter Dedon, Peter Preiser, Artur Scherf

Journal: MBio

PubMed ID: 34724812

Doi: 10.1128/mBio.02558-21

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MiR-574-5P, miR-1827, and miR-4429 as Potential Biomarkers for Schizophrenia

Authors: Omran Davarinejad, Sajad Najafi, Hossein Zhaleh, Farzaneh Golmohammadi, Farnaz Radmehr, Mostafa Alikhani, Reza Heidari Moghadam, Yazdan Rahmati

Journal: J Mol Neurosci

PubMed ID: 34811713

Doi: 10.1007/s12031-021-01945-0

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Involvement of the Heat Shock Protein HtpG of Typhimurium in Infection and Proliferation in Hosts

Authors: Tao Dong, Weiwei Wang, Minhao Xia, Shujie Liang, Guangzhong Hu, Hui Ye, Qingyun Cao, Zemin Dong, Changming Zhang, Dingyuan Feng, Jianjun Zuo

Journal: Front Cell Infect Microbiol

PubMed ID: 34869065

Doi: 10.3389/fcimb.2021.758898

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Tegument Protein pp150 Sequence-Specific Peptide Blocks Cytomegalovirus Infection

Authors: Dipanwita Mitra, Mohammad H Hasan, John T Bates, Gene L Bidwell, Ritesh Tandon

Journal: Viruses

PubMed ID: 34835083

Doi: 10.3390/v13112277

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Agonist/Antagonist Activity of Oxytocin Variants Obtained from Free Cyclic Peptide Libraries Generated via Amino Acid Substitution

Authors: Remi Kinoshita, Ikko Kozaki, Kazunori Shimizu, Takahiro Shibata, Akihito Ochiai, Hiroyuki Honda

Journal: ACS Omega

PubMed ID: 34841168

Doi: 10.1021/acsomega.1c04982

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Structural and Functional Characterization of a Biliverdin-Binding Near-Infrared Fluorescent Protein From the Serpin Superfamily

Authors: Kyrylo Yu Manoilov, Agnidipta Ghosh, Steven C Almo, Vladislav V Verkhusha

Journal: J Mol Biol

PubMed ID: 34798132

Doi: 10.1016/j.jmb.2021.167359

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Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load

Authors: Akihiro Kaneshige, Takayuki Kaji, Lidan Zhang, Hayato Saito, Ayasa Nakamura, Tamaki Kurosawa, Madoka Ikemoto-Uezumi, Kazutake Tsujikawa, Shigeto Seno, Masatoshi Hori, Yasuyuki Saito, Takashi Matozaki, Kazumitsu Maehara, Yasuyuki Ohkawa, Michael Potente, Shuichi Watanabe, Thomas Braun, Akiyoshi Uezumi, So-Ichiro Fukada

Journal: Cell Stem Cell

PubMed ID: 34856120

Doi: 10.1016/j.stem.2021.11.003

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The circular RNA circSLC7A11 functions as a mir-330-3p sponge to accelerate hepatocellular carcinoma progression by regulating cyclin-dependent kinase 1 expression

Authors: Yu Huang, Wenhao Ge, Yuan Ding, Lufei Zhang, Jiarong Zhou, Yang Kong, Bijun Cui, Bingqiang Gao, Xiaohui Qian, Weilin Wang

Journal: Cancer Cell Int

PubMed ID: 34844614

Doi: 10.1186/s12935-021-02351-7

Products & Services: Proteins, Expression, Isolation and Analysis

The synaptic scaffolding protein CNKSR2 interacts with CYTH2 to mediate hippocampal granule cell development

Authors: Hidenori Ito, Rika Morishita, Mariko Noda, Tomoki Ishiguro, Masashi Nishikawa, Koh-Ichi Nagata

Journal: J Biol Chem

PubMed ID: 34800437

Doi: 10.1016/j.jbc.2021.101427

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Mt10-CVB3 Vaccine Virus Protects against CVB4 Infection by Inducing Cross-Reactive, Antigen-Specific Immune Responses

Authors: Ninaad Lasrado, Rajkumar Arumugam, Mahima T Rasquinha, Meghna Sur, David Steffen, Jay Reddy

Journal: Microorganisms

PubMed ID: 34835449

Doi: 10.3390/microorganisms9112323

Products & Services: Proteins, Expression, Isolation and Analysis

An allergen-fused dendritic cell-binding peptide enhances in vitro proliferation of equine T-cells and cytokine production

Authors: Anja Ziegler, Judith Olzhausen, Eman Hamza, Ana Stojiljkovic, Michael H Stoffel, Mattia Garbani, Claudio Rhyner, Eliane Marti

Journal: Vet Immunol Immunopathol

PubMed ID: 34800874

Doi: 10.1016/j.vetimm.2021.110351

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Positively Regulates Pepper Immunity by Targeting against Inoculation through Modulating Defense-Related Genes

Authors: Ansar Hussain, Muhammad Ifnan Khan, Mohammed Albaqami, Shahzadi Mahpara, Ijaz Rasool Noorka, Mohamed A A Ahmed, Bandar S Aljuaid, Ahmed M El-Shehawi, Zhiqin Liu, Shahid Farooq, Ali Tan Kee Zuan

Journal: Int J Mol Sci

PubMed ID: 34769521

Doi: 10.3390/ijms222112091

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The pleiotropic functions of intracellular hydrophobins in aerial hyphae and fungal spores

Authors: Feng Cai, Zheng Zhao, Renwei Gao, Peijie Chen, Mingyue Ding, Siqi Jiang, Zhifei Fu, Pingyong Xu, Komal Chenthamara, Qirong Shen, Günseli Bayram Akcapinar, Irina S Druzhinina

Journal: PLoS Genet

PubMed ID: 34788288

Doi: 10.1371/journal.pgen.1009924

Products & Services: Proteins, Expression, Isolation and Analysis

A conserved guided entry of tail-anchored pathway is involved in the trafficking of a subset of membrane proteins in Plasmodium falciparum

Authors: Tarkeshwar Kumar, Satarupa Maitra, Abdur Rahman, Souvik Bhattacharjee

Journal: PLoS Pathog

PubMed ID: 34780541

Doi: 10.1371/journal.ppat.1009595

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TAL effector-dependent Bax gene expression in transgenic rice confers disease resistance to Xanthomonas oryzae pv oryzae

Authors: Yuejing Gui, Dongsheng Tian, Kar Hui Ong, Joanne Chin Yi Teo, Zhongchao Yin

Journal: Transgenic Res

PubMed ID: 34748132

Doi: 10.1007/s11248-021-00290-7

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Microinjection of pruritogens in NGF-sensitized human skin

Authors: Hans Jürgen Solinski, Roman Rukwied, Martin Schmelz

Journal: Sci Rep

PubMed ID: 34728705

Doi: 10.1038/s41598-021-00935-x

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Acute myeloid leukemia cell membrane-coated nanoparticles for cancer vaccination immunotherapy

Authors: Daniel T Johnson, Jiarong Zhou, Ashley V Kroll, Ronnie H Fang, Ming Yan, Crystal Xiao, Xiufen Chen, Justin Kline, Liangfang Zhang, Dong-Er Zhang

Journal: Leukemia

PubMed ID: 34845316

Doi: 10.1038/s41375-021-01432-w

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ThermoSlope: A Software for Determining Thermodynamic Parameters from Single Steady-State Experiments

Authors: Bjarte Aarmo Lund, Bjørn Olav Brandsdal

Journal: Molecules

Doi: 10.3390/molecules26237155

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A Novel Type of PD-L1 Inhibitor rU1 snRNPA From Human-Derived Protein Scaffolds Library

Authors: Chuang Ma, Sennan Qiao, Zhiyi Liu, Liang Shan, Chongyang Liang, Meiling Fan, Fei Sun

Journal: Front Oncol.

PubMed ID: 34912719

Doi: doi.org/10.3389/fonc.2021.781046

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SARS-CoV-2 exposure in wild white-tailed deer ()

Authors: Jeffrey C Chandler, Sarah N Bevins, Jeremy W Ellis, Timothy J Linder, Rachel M Tell, Melinda Jenkins-Moore, J Jeffrey Root, Julianna B Lenoch, Suelee Robbe-Austerman, Thomas J DeLiberto, Thomas Gidlewski, Mia Kim Torchetti, Susan A Shriner

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34732584

Doi: 10.1073/pnas.2114828118

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Author Correction: Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

Authors: Mohamed S Abdel-Hakeem, Sasikanth Manne, Jean-Christophe Beltra, Erietta Stelekati, Zeyu Chen, Kito Nzingha, Mohammed-Alkhatim Ali, John L Johnson, Josephine R Giles, Divij Mathew, Allison R Greenplate, Golnaz Vahedi, E John Wherry

Journal: Nat Immunol

PubMed ID: 34588688

Doi: 10.1038/s41590-021-01057-2

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Antibody neutralization to SARS-CoV-2 and variants after one year in Wuhan, China

Authors: Qianyun Liu, Qing Xiong, Fanghua Mei, Chengbao Ma, Zhen Zhang, Bing Hu, Junqiang Xu, Yongzhong Jiang, Faxian Zhan, Suhua Zhou, Li Tao, Xianying Chen, Ming Guo, Xin Wang, Yaohui Fang, Shu Shen, Yingle Liu, Fang Liu, Li Zhou, Ke Xu, Changwen Ke, Fei Deng, Kun Cai, Huan Yan, Yu Chen, Ke Lan

Journal: Innovation (N Y)

PubMed ID: 34746904

Doi: 10.1016/j.xinn.2021.100181

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