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Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery

Authors: Tian Zhou, Xinyi Zhu, Zhizhong Ye, Yong-Fei Wang, Chao Yao, Ning Xu, Mi Zhou, Jianyang Ma, Yuting Qin, Yiwei Shen, Yuanjia Tang, Zhihua Yin, Hong Xu, Yutong Zhang, Xiaoli Zang, Huihua Ding, Wanling Yang, Ya Guo, John B Harley, Bahram Namjou, Kenneth M Kaufman, Leah C Kottyan, Matthew T Weirauch, Guojun Hou, Nan Shen

Journal: Nat Commun

PubMed ID: 35388006

Doi: 10.1038/s41467-022-29514-y

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Distinct Stress-Dependent Signatures of Cellular and Extracellular tRNA-Derived Small RNAs

Authors: Guoping Li, Aidan C Manning, Alex Bagi, Xinyu Yang, Priyanka Gokulnath, Michail Spanos, Jonathan Howard, Patricia P Chan, Thadryan Sweeney, Robert Kitchen, Haobo Li, Brice D Laurent, Sary F Aranki, Maria I Kontaridis, Louise C Laurent, Kendall Van Keuren-Jensen, Jochen Muehlschlegel, Todd M Lowe, Saumya Das

Journal: Adv Sci (Weinh)

PubMed ID: 35373532

Doi: 10.1002/advs.202200829

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A Novel Multi-Epitope Edible Vaccine Candidate for Newcastle Disease Virus: Approach

Authors: Atena Mozafari, Jafar Amani, Shahla Shahsavandi, Ali Hatef Salmanian

Journal: Iran J Biotechnol

PubMed ID: 36337069

Doi: 10.30498/ijb.2022.298822.3119

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SNX27-Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling

Authors: Boris Simonetti, Qian Guo, Manuel Giménez-Andrés, Kai-En Chen, Edmund R R Moody, Ashley J Evans, Mintu Chandra, Chris M Danson, Tom A Williams, Brett M Collins, Peter J Cullen

Journal: PLoS Biol

PubMed ID: 35417450

Doi: 10.1371/journal.pbio.3001601

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Cellular Immune Response in Patients Immunized with Three Vaccine Doses of Different Vaccination Schemes Authorized by the Chilean Ministry of Health in January 2022

Authors: Paz Beatriz Tabilo Valenzuela, Gabriela Flores Balter, Gustavo Saint-Pierre Contreras, Daniel Conei Valencia, Catalina Moreno Calderón, Constanza Bohle Venegas, Marcia Guajardo Rivera, Francisco Silva Ojeda, Maria Jesus Vial Covarrubias

Journal: Life (Basel)

PubMed ID: 35455024

Doi: 10.3390/life12040534

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A Novel Immunochromatographic Strip Based on Latex Microspheres for the Rapid Detection of North American-Type Porcine Reproductive and Respiratory Syndrome Virus

Authors: Wansheng Li, Minhua Li, Hongliang Zhang, Chao Li, Hu Xu, Bangjun Gong, Jun Fu, Zhenyang Guo, Jinmei Peng, Guohui Zhou, Zhijun Tian, Qian Wang

Journal: Front Microbiol

PubMed ID: 35572691

Doi: 10.3389/fmicb.2022.882112

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Inhibitor of DNA binding 2 (ID2) regulates the expression of developmental genes and tumorigenesis in ewing sarcoma

Authors: Stacia L Koppenhafer, Kelli L Goss, Ellen Voigt, Emma Croushore, William W Terry, Jason Ostergaard, Peter M Gordon, David J Gordon

Journal: Oncogene

PubMed ID: 35422476

Doi: 10.1038/s41388-022-02310-0

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Construction of a Large Size Human Immunoglobulin Heavy Chain Variable (VH) Domain Library, Isolation and Characterization of Novel Human Antibody VH Domains Targeting PD-L1 and CD22

Authors: Zehua Sun, Wei Li, John W Mellors, Rimas Orentas, Dimiter S Dimitrov

Journal: Front Immunol

PubMed ID: 35464476

Doi: 10.3389/fimmu.2022.869825

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Type XX Collagen Is Elevated in Circulation of Patients with Solid Tumors

Authors: Jeppe Thorlacius-Ussing, Christina Jensen, Emilie A Madsen, Neel I Nissen, Tina Manon-Jensen, Inna M Chen, Julia S Johansen, Hadi M H Diab, Lars N Jørgensen, Morten A Karsdal, Nicholas Willumsen

Journal: Int J Mol Sci

PubMed ID: 35456962

Doi: 10.3390/ijms23084144

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-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone

Authors: Océane Tournière, James M Gahan, Henriette Busengdal, Natascha Bartsch, Fabian Rentzsch

Journal: Sci Adv

PubMed ID: 35442742

Doi: 10.1126/sciadv.abi7109

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Characterization of BLUF-photoreceptors present in Acinetobacter nosocomialis

Authors: Inés Abatedaga, Bárbara Perez Mora, Marisel Tuttobene, Gabriela Müller, Daiana Biancotti, Claudio D Borsarelli, Lorena Valle, Maria A Mussi

Journal: PLoS ONE

PubMed ID: 35442978

Doi: 10.1371/journal.pone.0254291

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The miR-532-E2F1 feedback loop contributes to gastric cancer progression

Authors: Shanting Gao, Xiaomin Bu, Yongyue Gao, Zengtao Bao, Wenchao Shi, Lipeng Luan, Huiyu Chen, Baoming Zhang, Qingshui Tian, Wenxian Guan, Liuqing Yang

Journal: Cell Death Dis

PubMed ID: 35440106

Doi: 10.1038/s41419-022-04832-7

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Immunization With Recombinant Y75B8A8 Partially Protects Local Crossbred Female Goats From Infection

Authors: Xiaowei Tian, Mingmin Lu, Yongqian Bu, Yang Zhang, Kalibixiati Aimulajiang, Meng Liang, Charles Li, Ruofeng Yan, Lixin Xu, Xiaokai Song, Xiangrui Li

Journal: Front Vet Sci

PubMed ID: 35445096

Doi: 10.3389/fvets.2022.765700

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Development of an Indirect ELISA Kit for Rapid Detection of Varicella-Zoster Virus Antibody by Glycoprotein E

Authors: Yan Niu, Aiping Wang, Jingming Zhou, Hongliang Liu, Yumei Chen, Peiyang Ding, Yanhua Qi, Chao Liang, Xifang Zhu, Gaiping Zhang

Journal: Front Microbiol

PubMed ID: 35572642

Doi: 10.3389/fmicb.2022.897752

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Design of Potent and Proteolytically Stable Biaryl-Stapled GLP-1R/GIPR Peptide Dual Agonists

Authors: Yifang Yang, Candy Lee, Reddy Rajasekhar Reddy, David J Huang, Weixia Zhong, Vân T B Nguyen-Tran, Weijun Shen, Qing Lin

Journal: ACS Chem Biol

PubMed ID: 35417146

Doi: 10.1021/acschembio.2c00175

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Suppression of lysosomal-associated protein transmembrane 5 ameliorates cardiac function and inflammatory response by inhibiting the nuclear factor-kappa B (NF-κB) pathway after myocardial infarction in mice

Authors: Zhanchun Song, Xiaozeng Wang, Lianqi He, Liang Chen, Zhichao Ren, Siyu Song

Journal: Exp Anim

PubMed ID: 35491099

Doi: 10.1538/expanim.22-0008

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Reverse Electron Transfer by Respiratory Complex I Catalyzed in a Modular Proteoliposome System

Authors: John J Wright, Olivier Biner, Injae Chung, Nils Burger, Hannah R Bridges, Judy Hirst

Journal: J Am Chem Soc

PubMed ID: 35380814

Doi: 10.1021/jacs.2c00274

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is a 3D matrix-specific mediator of mechanosensitive stem cell lineage commitment

Authors: Jieung Baek, Paola A Lopez, Sangmin Lee, Taek-Soo Kim, Sanjay Kumar, David V Schaffer

Journal: Sci Adv

PubMed ID: 35427160

Doi: 10.1126/sciadv.abm4646

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A single point mutation in the Plasmodium falciparum 3'-5' exonuclease does not alter piperaquine susceptibility

Authors: Nonlawat Boonyalai, Kirakarn Kirativanich, Chatchadaporn Thamnurak, Chantida Praditpol, Brian A Vesely, Mariusz Wojnarski, John S Griesenbeck, Norman C Waters

Journal: Malar J

PubMed ID: 35459163

Doi: 10.1186/s12936-022-04148-z

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Multi-Omics Analysis Reveals That Synergistically Regulates SGAs and Fruit Development

Authors: Hao Guo, Mengdi Mao, Yuan Deng, Lisong Sun, Ridong Chen, Peng Cao, Jun Lai, Yueran Zhang, Chao Wang, Chun Li, Yiran Li, Qunhang Bai, Tingting Tan, Jun Yang, Shouchuang Wang

Journal: Front Plant Sci

PubMed ID: 35463452

Doi: 10.3389/fpls.2022.860577

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MIMAS: microfluidic platform in tandem with MALDI mass spectrometry for protein quantification from small cell ensembles

Authors: Jorvani Cruz Villarreal, Rory Kruithoff, Ana Egatz-Gomez, Paul D Coleman, Robert Ros, Todd R Sandrin, Alexandra Ros

Journal: Anal Bioanal Chem

PubMed ID: 35385983

Doi: 10.1007/s00216-022-04038-y

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Expanding the Editing Window of Cytidine Base Editors With the Rad51 DNA-Binding Domain in Rice

Authors: Chunjie Wei, Hao Liu, Wenwen Wang, Pengyu Luo, Qiuling Chen, Rou Li, Chong Wang, José Ramón Botella, Hui Zhang

Journal: Front Plant Sci

PubMed ID: 35548314

Doi: 10.3389/fpls.2022.865848

Products & Services: Mammalian Expression

Artemether inhibits proliferation, invasion and migration of hepatocellular carcinoma cells via targeting of CYP2J2

Authors: Xionglin Zhu, Mei Yang, Zhiling Song, Guangbing Yao, Qifeng Shi

Journal: Oncol Lett

PubMed ID: 35464300

Doi: 10.3892/ol.2022.13300

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Hypericin nanoparticles for self-illuminated photodynamic cytotoxicity based on bioluminescence resonance energy transfer

Authors: Hao-Han Yu, Qiu-Ping Deng, Qing-Hua Zheng, Yi Wang, Jian Shen, Jia-Hong Zhou

Journal: Int J Pharm

PubMed ID: 35427744

Doi: 10.1016/j.ijpharm.2022.121738

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Secretes Small RNA to Target Host and Retard Plant Floral Transition During Infection

Authors: Bo-Sen Zhang, Ying-Chao Li, Hui-Shan Guo, Jian-Hua Zhao

Journal: Front Plant Sci

PubMed ID: 35519822

Doi: 10.3389/fpls.2022.847086

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Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24

Authors: Lingguang Yang, Laixing Zhang, Peipei Yin, Hao Ding, Yu Xiao, Jianwei Zeng, Wenhe Wang, Huan Zhou, Qisheng Wang, Yi Zhang, Zeliang Chen, Maojun Yang, Yue Feng

Journal: Nat Commun

PubMed ID: 35411005

Doi: 10.1038/s41467-022-29581-1

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N-terminal signal peptides facilitate the engineering of PVC complex as a potent protein delivery system

Authors: Feng Jiang, Jiawei Shen, Jiaxuan Cheng, Xia Wang, Jianguo Yang, Ningning Li, Ning Gao, Qi Jin

Journal: Sci Adv

PubMed ID: 35486720

Doi: 10.1126/sciadv.abm2343

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Characterization of Calcium-Dependent Protein Kinase 2A, a Potential Drug Target Against Cryptosporidiosis

Authors: Fanfan Shu, Yu Li, Wenlun Chu, Xuehua Chen, Ziding Zhang, Yaqiong Guo, Yaoyu Feng, Lihua Xiao, Na Li

Journal: Front Microbiol

PubMed ID: 35558125

Doi: 10.3389/fmicb.2022.883674

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Mechanism of RNA polymerase I selection by transcription factor UAF

Authors: Florence Baudin, Brice Murciano, Herman K H Fung, Simon A Fromm, Simone Mattei, Julia Mahamid, Christoph W Müller

Journal: Sci Adv

PubMed ID: 35442737

Doi: 10.1126/sciadv.abn5725

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Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Authors: Chao Wang, Li Fan, Rabia R Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T Grinberg, William W Seeley, Bruce L Miller, Sue-Ann Mok, Jason E Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Gan

Journal: Nat Commun

PubMed ID: 35413950

Doi: 10.1038/s41467-022-29552-6

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A Novel Homozygous Variant Leading to Type-1 Familial Glucocorticoid Deficiency

Authors: Idris Mohammed, Basma Haris, Khalid Hussain

Journal: J Endocr Soc

PubMed ID: 35506146

Doi: 10.1210/jendso/bvac058

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Structural insights into the peptide selectivity and activation of human neuromedin U receptors

Authors: Chongzhao You , Yumu Zhang , Peiyu Xu , Sijie Huang , Wanchao Yin, H Eric Xu , Yi Jiang

Journal: Nat Commun

PubMed ID: 35440625

Doi: 10.1038/s41467-022-29683-w

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Neutralizing antibody responses 300 days after SARS-CoV-2 infection and induction of high antibody titers after vaccination

Authors: Doris Urlaub, Natalie Wolfsdorff, Jan-Erik Hoffmann, Stefanie Dorok, Markus Hoffmann, Moritz Anft, Naomi Pieris, Patrick Günther, Bernhard Schaaf, Uwe Cassens, Peter Bröde, Maren Claus, Lea K Picard, Sabine Wingert, Simone Backes, Deniz Durak, Nina Babel, Stefan Pöhlmann, Frank Renken, Stefan Raunser, Carsten Watzl

Journal: Eur J Immunol

PubMed ID: 35247269

Doi: 10.1002/eji.202149758

Evaluation of a commercial ELISA as alternative to plaque reduction neutralization test to detect neutralizing antibodies against SARS-CoV-2

Authors: Natalie Hofmann, Marica Grossegesse, Markus Neumann, Lars Schaade, Andreas Nitsche

Journal: Sci Rep

PubMed ID: 35241780

Doi: 10.1038/s41598-022-07597-3

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Leptin secreted from testicular microenvironment modulates hedgehog signaling to augment the endogenous function of Leydig cells

Authors: Himanshu Arora, Rehana Qureshi, Kajal Khodamoradi, Deepa Seetharam, Madhumita Parmar, Derek J Van Booven, Isabelle Catherine Issa, Robert Sackstein, Dolores Lamb, Joshua M Hare, Ranjith Ramasamy

Journal: Cell Death Dis

PubMed ID: 35246515

Doi: 10.1038/s41419-022-04658-3

Products & Services: Gene Synthesis

Fast and sensitive detection of SARS-CoV-2 RNA using suboptimal protospacer adjacent motifs for Cas12a

Authors: Shuhan Lu, Xiaohan Tong, Yang Han, Kun Zhang, Yizhou Zhang, Qiubing Chen, Junyi Duan, Xinlin Lei, Muhan Huang, Yang Qiu, Ding-Yu Zhang, Xi Zhou, Ying Zhang, Hao Yin

Journal: Nat Biomed Eng

PubMed ID: 35314803

Doi: 10.1038/s41551-022-00861-x

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Evaluation of the Humoral Immune Response of a Heterologous Vaccination between BBIBP-CorV and BNT162b2 with a Temporal Separation of 7 Months, in Peruvian Healthcare Workers with and without a History of SARS-CoV-2 Infection

Authors: Miguel Hueda-Zavaleta, Juan C Gómez de la Torre, José Alonso Cáceres-Del Aguila, Cecilia Muro-Rojo, Nathalia De La Cruz-Escurra, Daniella Arenas Siles, Diana Minchón-Vizconde, Cesar Copaja-Corzo, Fabrizzio Bardales-Silva, Vicente A Benites-Zapata, Alfonso J Rodriguez-Morales

Journal: Vaccines (Basel)

PubMed ID: 35455251

Doi: 10.3390/vaccines10040502

Phage Therapy Potentiates Second-Line Antibiotic Treatment against Pneumonic Plague

Authors: Yaron Vagima, David Gur, Moshe Aftalion, Sarit Moses, Yinon Levy, Arik Makovitzki, Tzvi Holtzman, Ziv Oren, Yaniv Segula, Ella Fatelevich, Avital Tidhar, Ayelet Zauberman, Shahar Rotem, Emanuelle Mamroud, Ida Steinberger-Levy

Journal: Viruses

PubMed ID: 35458417

Doi: 10.3390/v14040688

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Structure-based design and construction of a synthetic phage display nanobody library

Authors: Ernesto Moreno, Mario S Valdés-Tresanco, Andrea Molina-Zapata, Oliberto Sánchez-Ramos

Journal: BMC Res Notes

PubMed ID: 35351202

Doi: 10.1186/s13104-022-06001-7

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Highly Specific Monoclonal Antibody Targeting the Botulinum Neurotoxin Type E Exposed SNAP-25 Neoepitope

Authors: Adva Mechaly, Eran Diamant, Ron Alcalay, Alon Ben David, Eyal Dor, Amram Torgeman, Ada Barnea, Meni Girshengorn, Lilach Levin, Eyal Epstein, Ariel Tennenhouse, Sarel J Fleishman, Ran Zichel, Ohad Mazor

Journal: Antibodies (Basel)

PubMed ID: 35323195

Doi: 10.3390/antib11010021

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COVID-19 Breakthrough Infection after Inactivated Vaccine Induced Robust Antibody Responses and Cross-Neutralization of SARS-CoV-2 Variants, but Less Immunity against Omicron

Authors: Nungruthai Suntronwong, Ritthideach Yorsaeng, Jiratchaya Puenpa, Chompoonut Auphimai, Thanunrat Thongmee, Preeyaporn Vichaiwattana, Sitthichai Kanokudom, Thaneeya Duangchinda, Warangkana Chantima, Pattarakul Pakchotanon, Suvichada Assawakosri, Pornjarim Nilyanimit, Sirapa Klinfueng, Lakkhana Wongsrisang, Donchida Srimuan, Thaksaporn Thatsanatorn, Natthinee Sudhinaraset, Nasamon Wanlapakorn, Yong Poovorawan

Journal: Vaccines (Basel)

PubMed ID: 35335023

Doi: 10.3390/vaccines10030391

Selection and Application of ssDNA Aptamers for Fluorescence Biosensing Detection of Malachite Green

Authors: Miaojia Xie, Zanlin Chen, Fengguang Zhao, Ying Lin, Suiping Zheng, Shuangyan Han

Journal: Foods

PubMed ID: 35327224

Doi: 10.3390/foods11060801

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A novel series of putative Brugia malayi histone demethylase inhibitors as potential anti-filarial drugs

Authors: Tamara Kreiss, Tyler Eck, Brittany Hart, Sreedhar Tummalapalli, David Rotella, John Siekierka

Journal: PLoS Negl Trop Dis

PubMed ID: 35294431

Doi: 10.1371/journal.pntd.0010216

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Performance of Chimeric Antigens in Serological Screening for Chagas Disease in Blood Banks

Authors: Emily Ferreira Dos Santos, Ângelo Antônio Oliveira Silva, Natália Erdens Maron Freitas, Leonardo Maia Leony, Ramona Tavares Daltro, Carlos Antônio de Souza Teles Santos, Maria da Conceição Chagas de Almeida, Fernando Luiz Vieira de Araújo, Paola Alejandra Fiorani Celedon, Marco Aurélio Krieger, Nilson Ivo Tonin Zanchin, Mitermayer Galvão Dos Reis, Fred Luciano Neves Santos

Journal: Front Med (Lausanne)

PubMed ID: 35330587

Doi: 10.3389/fmed.2022.852864

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Sequence-specific destabilization of azurin by tetramethylguanidinium-dipeptide ionic liquids

Authors: Roshani Patel, Austin K Clark, Gabriella DeStefano, Isabella DeStefano, Hunter Gogoj, Erin Gray, Aashka Y Patel, Joshua T Hauner, Gregory A Caputo, Timothy D Vaden

Journal: Biochem Biophys Rep

PubMed ID: 35280523

Doi: 10.1016/j.bbrep.2022.101242

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The protective effects of butorphanol tartrate against homocysteine-induced blood-brain barrier dysfunction

Authors: Sufeng Shen, Jiandong Wang, Qingyuan Zhao, Qiangfu Hu

Journal: Bioengineered

PubMed ID: 35245993

Doi: 10.1080/21655979.2022.2037953

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Pull-Down Into Active Inclusion Bodies and Their Application in the Detection of (Poly)-Phosphates and Metal-Ions

Authors: Eva Hrabarova, Martina Belkova, Romana Koszagova, Jozef Nahalka

Journal: Front Bioeng Biotechnol

PubMed ID: 35299638

Doi: 10.3389/fbioe.2022.833192

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Rituximab-treated patients with lymphoma develop strong CD8 T-cell responses following COVID-19 vaccination

Authors: Jon Riise, Saskia Meyer, Isaac Blaas, Adity Chopra, Trung T Tran, Marina Delic-Sarac, Malu Lian Hestdalen, Ellen Brodin, Even Holth Rustad, Ke-Zheng Dai, John Torgils Vaage, Lise Sofie Haug Nissen-Meyer, Fredrik Sund, Karin F Wader, Anne T Bjornevik, Peter A Meyer, Gro O Nygaard, Marton König, Sigbjørn Smeland, Fridtjof Lund-Johansen, Johanna Olweus, Arne Kolstad

Journal: Br J Haematol

PubMed ID: 35254660

Doi: 10.1111/bjh.18149

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Polycystin-1 regulates cell proliferation and migration through AKT/mTORC2 pathway in a human craniosynostosis cell model

Authors: Maria A Katsianou, Kostas A Papavassiliou, Antonios N Gargalionis, George Agrogiannis, Penelope Korkolopoulou, Dimitrios Panagopoulos, Marios S Themistocleous, Christina Piperi, Efthimia K Basdra, Athanasios G Papavassiliou

Journal: J Cell Mol Med

PubMed ID: 35285136

Doi: 10.1111/jcmm.17266

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Modified vaccinia Ankara expressing EEHV1A glycoprotein B elicits humoral and cell-mediated immune responses in mice

Authors: Taylor Pursell, Jennifer L Spencer Clinton, Jie Tan, Rongsheng Peng, Paul D Ling

Journal: PLoS ONE

PubMed ID: 35312707

Doi: 10.1371/journal.pone.0265424

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