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Deep mutational scanning and machine learning for the analysis of antimicrobial-peptide features driving membrane selectivity

Authors: Justin R. Randall; Luiz C. Vieira; Claus O. Wilke; Bryan W. Davies

Journal: Nature biomedical engineering

PubMed ID: 39085646

Doi: 10.1038/s41551-024-01243-1

Products & Services: Peptide Synthesis

Deep mutational scanning and machine learning for the analysis of antimicrobial-peptide features driving membrane selectivity

Authors: Justin R. Randall; Luiz C. Vieira; Claus O. Wilke; Bryan W. Davies

Journal: Nature biomedical engineering

PubMed ID: 39085646

Doi: 10.1038/s41551-024-01243-1

Products & Services: Peptide Synthesis

Probing SARS-CoV-2 membrane binding peptide via single-molecule AFM-based force spectroscopy

Authors: Qingrong Zhang, Raissa S. L. Rosa, Ankita Ray, Kimberley Durlet, Gol Mohammad Dorrazehi, Rafael C. Bernardi & David Alsteens

Journal: Nature Communications

PubMed ID: 39747000

Doi: 10.1038/s41467-024-55358-9

Products & Services: Peptide Synthesis

MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis

Authors: Sarah V. Faull, Marta Barbon, Audrey Mossler, Zuanning Yuan, Lin Bai, L. Maximilian Reuter, Alberto Riera, Christian Winkler, Indiana Magdalou, Matthew Peach, Huilin Li & Christian Speck

Journal: Nature Communications

PubMed ID: 39747125

Doi: 10.1038/s41467-024-55479-1

Products & Services: Mutagenesis Services

Dietary amino acids promote glucagon-like hormone release to generate global calcium waves in adipose tissues in Drosophila

Authors: Muhammad Ahmad, Shang Wu, Shengyao Luo, Wenjia Shi, Xuan Guo, Yuansheng Cao, Norbert Perrimon & Li He

Journal: Nature Communications

PubMed ID: 39747032

Doi: 10.1038/s41467-024-55371-y

Products & Services: Peptide Synthesis

Regulation of N-degron recognin-mediated autophagy by the SARS-CoV-2 PLpro ubiquitin deconjugase

Authors: Carlos Ayala-Torres , Jiangnan Liu , Nico P Dantuma , Maria G Masucci

Journal: Autophagy

PubMed ID: 39723606

Doi: 10.1080/15548627.2024.2442849

Products & Services: Gene Synthesis

Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates

Authors: Jennifer N. Wells, Lucy V. Edwardes, Vera Leber, Shenaz Allyjaun, Matthew Peach, Joshua Tomkins, Antonia Kefala-Stavridi, Sarah V. Faull, Ricardo Aramayo, Carolina M. Pestana, Lepakshi Ranjha & Christian Speck

Journal: Nature Communications

PubMed ID: 39779677

Doi: 10.1038/s41467-024-55772-z

Products & Services: Gene Synthesis

Screening the human miRNA interactome reveals coordinated up-regulation in melanoma, adding bidirectional regulation to miRNA networks

Authors: Faezeh Jame-Chenarboo , Joseph N Reyes , Nicholas M Twells , Hoi Hei Ng , Dawn Macdonald , Eva Hernando , Lara K Mahal

Journal: SCIENCE ADVANCES

PubMed ID: 39792681

Doi: 10.1126/sciadv.adr0277

Products & Services: Gene Synthesis

f the human autophagy factor EPG5 and the molecular basis of its conserved mode of interaction with Atg8-family proteins

Authors: Yiu Wing Sunny Cheung , Sung-Eun Nam , Gage M J Fairlie , Karlton Scheu , Jennifer M Bui , Hannah R Shariati , Jörg Gsponer , Calvin K Yip

Journal: Autophagy

PubMed ID: 39809444

Doi: 10.1080/15548627.2024.2447213

Products & Services: Peptide Synthesis

Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin

Authors: Jeonghyun Oh, Christy Catherine, Eun Seon Kim, Kwang Wook Min, Hae Chan Jeong, Hyojin Kim, Mijin Kim, Seung Hae Ahn, Nataliia Lukianenko, Min Gu Jo, Hyeon Seok Bak, Sungsu Lim, Yun Kyung Kim, Ho Min Kim, Sung Bae Lee & Hyunju Cho

Journal: Nature Communications

PubMed ID: 39824813

Doi: 10.1038/s41467-025-56030-6

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