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Complement factor H targeting antibody GT103 in refractory non-small cell lung cancer: a phase 1b dose escalation trial

Authors: Jeffrey M. Clarke, George R. Simon, Hirva Mamdani, Lin Gu, James E. Herndon II, Thomas E. Stinchcombe, Neal Ready, Jeffrey Crawford, Guru Sonpavde, Stephen Balevic, Andrew B. Nixon, Michael Campa, Elizabeth B. Gottlin, Huihua Li, Ruchi Saxena, You Wen He, Scott Antonia & Edward F. Patz Jr

Journal: Nature Communications

PubMed ID: 39747856

Doi: 10.1038/s41467-024-55092-2

Products & Services: Peptide Synthesis

Klp2-mediated Rsp1-Mto1 colocalization inhibits microtubule-dependent microtubule assembly in fission yeast

Authors: Lingyun Nie , Wenyue Liu , Zhuobi Liang , Fan Zheng , Xing Liu , Xuebiao Yao , Shengqi Xiang , Kai Jiang , Shengnan Zheng , Chuanhai Fu

Journal: SCIENCE ADVANCES

PubMed ID: 39752482

Doi: 10.1126/sciadv.adq0670

Products & Services: Polyclonal Antibody Services

Large-scale multicenter study reveals anticitrullinated SR-A peptide antibody as a biomarker and exacerbator for rheumatoid arthritis

Authors: by Yang XieChaonan WeiDongdong FuWei ZhangYan DuChuncui HuangShuyan LiuRanran YaoZihao HeShenghua ZhangXu JinBin ShenLulu CaoPing WangXiangyu FangXi ZhengHongying LinXihua WeiWenhao LinMingxin BaiDanxue ZhuYingni LiYamin DingHuaqun ZhuHua YeJing HeYin SuYuan JiaHuaxiang WuYongfu WangDan XingXiaoyan QiuZhanguo LiFanlei Hu

Journal: SCIENCE ADVANCES

PubMed ID: 39752500

Doi: 10.1126/sciadv.adr8078

Products & Services: Endotoxin Detection & Removal System

Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice

Authors: Peter J. Halfmann, Raj S. Patel, Kathryn Loeffler, Atsuhiro Yasuhara, Lee-Ann Van De Velde, Jie E. Yang, Jordan Chervin, Chloe Troxell, Min Huang, Naiying Zheng, Elizabeth R. Wright, Paul G. Thomas, Patrick C. Wilson, Yoshihiro Kawaoka & Ravi S. Kane

Journal: Nature Communications

PubMed ID: 39774966

Doi: 10.1038/s41467-025-55824-y

Products & Services: Custom Vector Construction

Structural and bioinformatics analyses identify deoxydinucleotide-specific nucleases and their association with genomic islands in gram-positive bacteria

Authors: Sofia Mortensen, Stanislava Kuncová, Justin D Lormand, Tanner M Myers, Soo-Kyoung Kim, Vincent T Lee, Wade C Winkler, Holger Sondermann

Journal: Nucleic Acids Research

PubMed ID: 39778863

Doi: 10.1093/nar/gkae1235

Products & Services: Gene Synthesis

Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

Authors: Mingjiong Zhang, Jiahua Cui, Haoyan Chen, Yifan Cheng, Qiaoyu Chen, Feng Zong, Xiao Lu, Lang Qin, Yu Han, Xingwang Kuai, Yuxing Zhang, Minjie Chu, Shuangshuang Wu & Jianqing Wu

Journal: Nature Communications

PubMed ID: 39805872

Doi: 10.1038/s41467-025-56002-w

Products & Services: Protein and Antibody Reagents

Scale-free Spatio-temporal Correlations in Conformational Fluctuations of Intrinsically Disordered Proteins

Authors: Haoyu Song, Jian Cui, Guorong Hu, Long Xiong, Yanee Wutthinitikornkit, Hai Lei, Jingyuan Li

Journal: Advanced Science

PubMed ID: 39807013

Doi: 10.1002/advs.202412989

Products & Services: Gene Synthesis

Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines

Authors: Lee Sherry, Mohammad W. Bahar, Claudine Porta, Helen Fox, Keith Grehan, Veronica Nasta, Helen M. E. Duyvesteyn, Luigi De Colibus, Johanna Marsian, Inga Murdoch, Daniel Ponndorf, Seong-Ryong Kim, Sachin Shah, Sarah Carlyle, Jessica J. Swanson, Sue Matthews, Clare Nicol, George P. Lomonossoff, Andrew J. Macadam, Elizabeth E. Fry, David I. Stuart, Nicola J. Stonehouse & David J. Rowlands

Journal: Nature Communications

PubMed ID: 39827284

Doi: 10.1038/s41467-025-56118-z

Products & Services: Gene Fragments

Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer

Authors: Ryan Blawski; Bujamin H. Vokshi; Xinyu Guo; Srushti Kittane; Mirna Sallaku; Wanlu Chen; Martina Gjyzari; Tony Cheung; Yuhan Zhang; Christopher Simpkins; Weiqiang Zhou; Amanda Kulick; Peihua Zhao; Meihan Wei; Pranavkrishna Shivashankar; Tatiana Prioleau; Pedram Razavi; Richard Koche; Vito W. Rebecca; Elisa de Stanchina; Pau Castel; Ho Man Chan; Maurizio Scaltriti; Emiliano Cocco; Hongkai Ji; Minkui Luo; Eneda Toska

Journal: Cell Reports

PubMed ID: 38700982

Doi: 10.1016/j.celrep.2024.114174

Products & Services: Peptide Synthesis

Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer

Journal: Cell Reports

PubMed ID: 38700982

Doi: 10.1016/j.celrep.2024.114174

Products & Services: Peptide Synthesis