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Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes

Authors: Markéta Novotná, Michele Tinti, Joana R C Faria, David Horn

Journal: Nature Communications

PubMed ID: 40615444

Doi: 10.1038/s41467-025-61480-z

Products & Services: PCR Cloning and Subcloning

FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses

Authors: Choah Kim, Katlyn R Gabriel, Dylan Boone, Matthew R Brown, Katherine Oppenheimer, Maria Kost-Alimova, Juan Lorenzo B Pablo, Anna Greka

Journal: SCIENCE ADVANCES

PubMed ID: 40601736

Doi: 10.1126/sciadv.adu9104

Products & Services: Lentivirus Packaging

Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail

Authors: J Atherton, M S Chegkazi, M Leusciatti, M Di Palma, E Peirano, L S Pozzer, M V A Meli, S Pasqualato, T Foran, G Morra, R A Steiner

Journal: Nature Communications

PubMed ID: 40617823

Doi: 10.1038/s41467-025-61498-3

Products & Services: Mammalian Expression

Continuous in situ synthesis of a complete set of tRNAs sustains steady-state translation in a recombinant cell-free system

Authors: Fanjun Li , Amogh Kumar Baranwal , Sebastian J Maerkl

Journal: Nature Communications

PubMed ID: 40617857

Doi: 10.1038/s41467-025-61671-8

Products & Services: Gene Synthesis

Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma

Authors: Bartimée Galvan, Loïc Ongena, Jonathan Bruyr, Gregory Fettweis, Eva Lucarelli, Arnaud Lavergne, Emeline Mariavelle, Tina M O'Grady, Zahrat El Oula Hassoun, Margaux Claes, Laurence Dubois, Kevin A W Lee, Véronique Kruys, Cyril Gueydan, Jules Durand, Eric Hervouet, Florian H Geyer, Ana Banito, Roland Imle, Lianghao Mao, Ashok K Jayavelu, Thomas G P Grünewald, Florencia Cidre-Aranaz, Jean-Claude Twizere, Franck Dequiedt

Journal: Nature Communications

PubMed ID: 40664627

Doi: 10.1038/s41467-025-61725-x

Products & Services: Custom Vector Construction

Single-cell RNA sequencing and PANDORA-seq reveal the pivotal role of piRNA in heat stress-induced testicular injury

Authors: Mailin Gan, Jianfeng Ma, Yuhang Lei, Yiting Yang, Yuheng Pan, Shuang Wu, Siyu Chen, Jiaxin Li, Linyuan Shen, Li Zhu

Journal: International Journal of Biological Macromolecules

PubMed ID: 40609925

Doi: 10.1016/j.ijbiomac.2025.145674

Products & Services: Protein and Antibody Isolation

The evolution of eukaryotic linear motifs governing the function of androgen receptor from fish to Homo sapiens

Authors: Antonella Falconieri, Giulia Boarolo, Chiara Boschelle, Giovanni Spagnolli, Caterina Marchioretti, Emanuela Zuccaro, Isabella Palazzolo, Laura Tosatto, Adham Kamaleldeen Omara Hegazy, Jessica Rosati, Kenneth Fischbeck, Manuela Basso, Hans Christoph Liedtke, Ivan Gomez-Mestre, Luisa Dalla Valle, Emiliano Biasini, Pietro Faccioli, Alessandro Grapputo, Maria Pennuto

Journal: Nucleic acids research

PubMed ID: 40682815

Doi: 10.1093/nar/gkaf688

Products & Services: Custom Vector Construction

Extracellular CIRP dysregulates microglial efferocytosis in ischemic stroke via the TLR4/miR-155/MafB axis

Authors: Dmitriy Lapin; Dilara Aylar; Archna Sharma; Ping Wang

Journal: research square

PubMed ID: 40766256

Doi: 10.21203/rs.3.rs-7223452/v1

Products & Services: Peptide Synthesis

Engineering precision zebrafish alleles of human disease

Authors: Holly R. Thomas; Bradley K. Yoder; Matthew S. Alexander; John M. Parant

Journal: biorxiv

PubMed ID: 40475461

Doi: 10.1101/2025.05.18.654701

Products & Services: Molecular Biology Reagents

The herpes simplex origin-binding protein: mechanisms for sequence-specific DNA binding and dimerization revealed by Cryo-EM

Authors: Emil Gustavsson; Kay Gr newald; Per Elias; B Martin H llberg

Journal: Nucleic Acids Research

PubMed ID: 41125242

Doi: 10.1093/nar/gkaf1029