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Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A

Authors: Nitesh Kumar Khandelwal, Meghna Gupta, James E Gomez, Sulyman Barkho, Ziqiang Guan, Ashley Y Eng, Tomohiko Kawate, Sree Ganesh Balasubramani, Andrej Sali, Deborah T Hung, Robert M Stroud

Journal: Nature Communications

PubMed ID: 40169593

Doi: 10.1038/s41467-025-58133-6

Products & Services: Mutagenesis Services

Ara-C suppresses H3 K27–altered spinal cord diffuse midline glioma growth and enhances immune checkpoint blockade sensitivity

Authors: Bo Pang, Yilin Wu, SongYuan An, Yuzhou Chang, Hao Yan, Han Lin, Zheng Zhao, Fan Wu, Qing Chang, Wenqing Jia, Tao Jiang, Yongzhi Wang, Ruichao Chai

Journal: SCIENCE ADVANCES

PubMed ID: 40238864

Doi: 10.1126/sciadv.adu3956

Products & Services: Protein Electrophoresis and Western

Multimeric transcription factor BCL11A utilizes two zinc-finger tandem arrays to bind clustered short sequence motifs

Authors: John R. Horton, Meigen Yu, Jujun Zhou, Melody Tran, Rithvi R. Anakal, Yue Lu, Robert M. Blumenthal, Xiaotian Zhang, Yun Huang, Xing Zhang & Xiaodong Cheng

Journal: Nature Communications

PubMed ID: 40246927

Doi: 10.1038/s41467-025-58998-7

Products & Services: Gene Synthesis

Engineering aptamer-directed phosphatase recruiting chimeras: a strategy for modulating receptor function and overcoming drug resistance

Authors: Zhilan Zhou, Yichang Liu, Ya Wang, Hang Jiang, Tingting Chen, Yingdi Zhu, Ting Fu, Juan Li

Journal: Nature Communications

PubMed ID: 40280908

Doi: 10.1038/s41467-025-59098-2

Products & Services: Protein Electrophoresis and Western

Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe

Authors: Pedro Ortega, Elodie Bournique, Junyi Li, Ambrocio Sanchez, Gisselle Santiago, Brooke R Harris, Josefine Striepen, John Maciejowski, Abby M Green, Rémi Buisson

Journal: SCIENCE ADVANCES

PubMed ID: 40238882

Doi: 10.1126/sciadv.adu0437

Products & Services: Gene Synthesis

Structural basis of human Mediator recruitment by the phosphorylated transcription factor Elk-1

Authors: Vincent Villeret

Journal: Nature Communications

PubMed ID: 40263353

Doi: 10.1038/s41467-025-59014-8

Products & Services: Gene Synthesis

Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance

Authors: Amanda L. Waterbury, Jonatan Caroli, Olivia Zhang, Paloma R. Tuttle, Chao Liu, Jiaming Li, Ji Sung Park, Samuel M. Hoenig, Marco Barone, Airi Furui, Andrea Mattevi & Brian B. Liau

Journal: Nature Communications

PubMed ID: 40175327

Doi: 10.1038/s41467-025-57477-3

Products & Services: Peptide Synthesis

Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine

Authors: Kalvis Brangulis, Jill Malfetano, Ashley L. Marcinkiewicz, Alan Wang, Yi-Lin Chen, Jungsoon Lee, Zhuyun Liu, Xiuli Yang, Ulrich Strych, Dagnija Tupina, Inara Akopjana, Maria-Elena Bottazzi, Utpal Pal, Ching-Lin Hsieh, Wen-Hsiang Chen & Yi-Pin Lin

Journal: Nature Communications

PubMed ID: 40189575

Doi: 10.1038/s41467-025-58182-x

Products & Services: Gene Synthesis

Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer

Authors: Kai-En Chen, Vikas A. Tillu, Navin Gopaldass, Sudeshna Roy Chowdhury, Natalya Leneva, Oleksiy Kovtun, Juanfang Ruan, Qian Guo, Nicholas Ariotti, Andreas Mayer & Brett M. Collins

Journal: Nature Communications

PubMed ID: 40234461

Doi: 10.1038/s41467-025-58846-8

Products & Services: Gene Fragments

Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5

Authors: Zhefan Stephen Chen, Shaohong Isaac Peng, Lok I Leong, Terence Gall-Duncan, Nathan Siu Jun Wong, Tsz Ho Li, Xiao Lin, Yuming Wei, Alex Chun Koon, Junzhe Huang, Jacquelyne Ka-Li Sun, Clinton Turner, Lynette Tippett, Maurice A. Curtis, Richard L. M. Faull, Kin Ming Kwan, Hei-Man Chow, Ho Ko, Ting-Fung Chan, Kevin Talbot, Christopher E. Pearson & Ho Yin Edwin Chan

Journal: Nature Communications

PubMed ID: 40204699

Doi: 10.1038/s41467-025-58618-4

Products & Services: Gene Synthesis