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Small molecule targeting CELF1 RNA-binding activity to control HSC activation and liver fibrosis

Authors: Yang Tan, Xueqing Sun, Yizhu Xu, Bingjie Tang, Shuaiqi Xu, Dong Lu, Yan Ye, Xiaomin Luo, Xu Diao, Fulong Li, Tianyi Wang, Jiayu Chen, Qiang Xu, Xingxin Wu

Journal: Nucleic Acids Res

PubMed ID: 35234905

Doi: 10.1093/nar/gkac139

Products & Services: DNA Sequencing

Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors

Authors: Jia Duan , Dan-Dan Shen , Tingting Zhao , Shimeng Guo , Xinheng He , Wanchao Yin , Peiyu Xu , Yujie Ji , Li-Nan Chen , Jinyu Liu , Huibing Zhang , Qiufeng Liu , Yi Shi , Xi Cheng , Hualiang Jiang , H Eric Xu , Yan Zhang , Xin Xie , Yi Jiang

Journal: Nat Commun

PubMed ID: 35292680

Doi: 10.1038/s41467-022-29072-3

Products & Services: Catalog Peptides

A scalable serology solution for profiling humoral immune responses to SARS-CoV-2 infection and vaccination

Authors: Karen Colwill, Yannick Galipeau, Matthew Stuible, Christian Gervais, Corey Arnold, Bhavisha Rathod, Kento T Abe, Jenny H Wang, Adrian Pasculescu, Mariam Maltseva, Lynda Rocheleau, Martin Pelchat, Mahya Fazel-Zarandi, Mariam Iskilova, Miriam Barrios-Rodiles, Linda Bennett, Kevin Yau, François Cholette, Christine Mesa, Angel X Li, Aimee Paterson, Michelle A Hladunewich, Pamela J Goodwin, Jeffrey L Wrana, Steven J Drews, Samira Mubareka, Allison J McGeer, John Kim, Marc-André Langlois, Anne-Claude Gingras, Yves Durocher

Journal: Clin Transl Immunology

PubMed ID: 35356067

Doi: 10.1002/cti2.1380

Products & Services: Codon Optimization

Degenerate sequence-based CRISPR diagnostic for Crimean-Congo hemorrhagic fever virus

Authors: Hongzhao Li, Alexander Bello, Greg Smith, Dominic M S Kielich, James E Strong, Bradley S Pickering

Journal: PLoS Negl Trop Dis

PubMed ID: 35271569

Doi: 10.1371/journal.pntd.0010285

Products & Services: PCR Cloning and Subcloning

Adjusted degradation of BRD4 S and BRD4 L based on fine structural modifications of the pyrrolopyridone scaffold

Authors: Jingjing Chen, Huixin He, Aihuan Wei, Yalei Li, Gang Cheng, Hui Qin, Hanyue Zhong, Hongchun Liu, Meiyu Geng, Aijun Shen, Youhong Hu

Journal: Eur J Med Chem

PubMed ID: 35395439

Doi: 10.1016/j.ejmech.2022.114259

Products & Services: Protein Electrophoresis and Western

Convergent epitope specificities, V gene usage and public clones elicited by primary exposure to SARS-CoV-2 variants

Authors: Noemia S Lima, Maryam Mukhamedova, Timothy S Johnston, Danielle A Wagner, Amy R Henry, Lingshu Wang, Eun Sung Yang, Yi Zhang, Kevina Birungi, Walker P Black, Sijy O'Dell, Stephen D Schmidt, Damee Moon, Cynthia G Lorang, Bingchun Zhao, Man Chen, Kristin L Boswell, Jesmine Roberts-Torres, Rachel L Davis, Lowrey Peyton, Sandeep R Narpala, Sarah O'Connell, Jennifer Wang, Alexander Schrager, Chloe Adrienna Talana, Kwanyee Leung, Wei Shi, Rawan Khashab, Asaf Biber, Tal Zilberman, Joshua Rhein, Sara Vetter, Afeefa Ahmed, Laura Novik, Alicia Widge, Ingelise Gordon, Mercy Guech, I-Ting Teng, Emily Phung, Tracy J Ruckwardt, Amarendra Pegu, John Misasi, Nicole A Doria-Rose, Martin Gaudinski, Richard A Koup, Peter D Kwong, Adrian B McDermott, Sharon Amit, Timothy W Schacker, Itzchak Levy, John R Mascola, Nancy J Sullivan, Chaim A Schramm, Daniel C Douek

Journal: biorxiv

PubMed ID: 35378757

Doi: 10.1101/2022.03.28.486152

Products & Services: Peptide Synthesis

Induction of broadly neutralizing antibodies using a secreted form of the hepatitis C virus E1E2 heterodimer as a vaccine candidate

Authors: Ruixue Wang, Saori Suzuki, Johnathan D Guest, Brigitte Heller, Maricar Almeda, Alexander K Andrianov, Alexander Marin, Roy A Mariuzza, Zhen-Yong Keck, Steven K H Foung, Abdul S Yunus, Brian G Pierce, Eric A Toth, Alexander Ploss, Thomas R Fuerst

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35263223

Doi: 10.1073/pnas.2112008119

Products & Services: PCR Cloning and Subcloning

Rapid Exchange of Stably Bound Protein and DNA Cargo on a DNA Origami Receptor

Authors: James W P Brown, Rokiah G Alford, James C Walsh, Richard E Spinney, Stephanie Y Xu, Sophie Hertel, Jonathan F Berengut, Lisanne M Spenkelink, Antoine M van Oijen, Till Böcking, Richard G Morris, Lawrence K Lee

Journal: ACS Nano

PubMed ID: 35316035

Doi: 10.1021/acsnano.2c00699

Products & Services: Custom Vector Construction

In situ solid-state NMR study of antimicrobial peptide interactions with erythrocyte membranes

Authors: Kiran Kumar, Mathew Sebastiao, Alexandre A Arnold, Steve Bourgault, Dror E Warschawski, Isabelle Marcotte

Journal: Biophys J

PubMed ID: 35278426

Doi: 10.1016/j.bpj.2022.03.009

Products & Services: Peptide Synthesis

Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis

Authors: Yiqi Yang , Yixuan Lin , Minqi Wang , Kai Yuan , Qishan Wang , Pei Mu , Jingke Du , Zhifeng Yu , Shengbing Yang ， Kai Huang , Yugang Wang , Hanjun Li , Tingting Tang

Journal: Bone Res

PubMed ID: 35260560

Doi: doi.org/10.1038/s41413-022-00198-w

Products & Services: Protein Electrophoresis and Western