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Cynarin as a potent anti‑osteolytic agent: Targeting MAPK and Nrf2‑Keap1 pathways for osteoclast inhibition and bone protection
Authors: Rui Chao, Yexin Wang, Zhan Liu, Tianhao Wan, Yi Mao, Xinru Xie, Lei Sun, Weifeng Xu, Xuzhuo Chen, Shanyong Zhang
Journal: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
PubMed ID: PMC12488209
Doi: 10.3892/ijmm.2025.5647
Engineered ipilimumab variants that bind human and mouse CTLA-4
Authors: Brett Robison 1, S J Diong 1, Anusha Kumar 1, Thomas M Moon , Olin Chang , Bryant Chau , Christine Bee , Ishita Barman , Arvind Rajpal , Alan J Korman , Sean West , Pavel Strop , Peter S Lee
Journal: MAbs
PubMed ID: 39849917
Doi: 10.1080/19420862.2025.2451296
Products & Services: Combinatorial DNA Libraries   
A novel low-cost and sensitive electrochemical biosensor based on Yb-protein/GO/SPE for rare earth element detection
Authors: Ting Zhang, Danni Ma, Jiaxing Gong, Bolun Sun, Fuman Cai
Journal: Sustainable Chemistry and Pharmacy
Doi: doi.org/10.1016/j.scp.2025.102248
Products & Services: Molecular Biology Reagents   
De novo designed voltage-gated anion channels suppress neuron firing
Authors: Chen Zhou, Huican Li, Jiaxing Wang, Cheng Qian, Hui Xiong, Zhilin Chu, Qiming Shao, Xuan Li, Shijin Sun, Ke Sun, Aiqin Zhu, Jiawei Wang, Xueqin Jin, Fan Yang, Tamer M Gamal El-Din, Bo Li, Jing Huang, Kun Wu, Peilong Lu
Journal: Cell
PubMed ID: 41106381
Doi: 10.1016/j.cell.2025.09.023
Journal of Controlled Release
Authors: Fei Li, Quan Wang, Tingting Wang, Chen Xiong, Ziling Chen, Hanzhi Ouyang, Xiaoding Lou, Fan Xia, Shixuan Wang, Meng Wu, Jun Dai
Journal: Journal of controlled release
Doi: 10.1016/j.jconrel.2025.114337
Products & Services: Plasmid DNA Preparation   
Discovery of a Serine-Directed Chemical Reaction for Site-Specific Protein Modification via Phage Display Screening
Authors: Yingjie Lei, Kai Zhao, Mengzhun Guo, Liang Guo, Jinfeng Chen, Mengjiao Li, Dandan Liu, Kai Chen, Jiahao Mei, Tian Li, Bing Yang, Jing Huang, Bobo Dang
Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
PubMed ID: 41108661
Doi: doi.org/10.1002/anie.202514412
Noncanonical target-strand cytosine base editing via engineered Un1Cas12f1 platform
Authors: Ziguo Song, Junfan Guo, Zhanqing Fan, Shuhong Huang, Guanglei Li, Zichang Zhao, Bingchun Chen, Shisheng Huang, Wenxin Zheng, Yinghui Wei, Yulin Chen, Xingxu Huang, Jianghuai Liu, Lina Wu, Xiaolong Wang
Journal: Nature Communications
PubMed ID: 41152217
Doi: 10.1038/s41467-025-64562-0
Products & Services: Plasmid DNA Preparation   
ROS-triggered self-assembling peptide hydrogel combining bacterial entrapment and intracellular penetration for Salmonella Typhimurium-induced enteritis therapy
Authors: Wenwen Meng, Hao Yang, Wenqian Zhang, Xueyan Li, Jiajun Sun, Ting Hu, Wei Li, Yaohong Zhu, Yong Wang, Xi Ma, Guiyan Yang, Jiufeng Wang
Journal: Chemical Engineering Journal
Doi: doi.org/10.1016/j.cej.2025.169392
Products & Services: Peptide Synthesis   
Metabolic Hijacking by Engineered Probiotics Reprograms Tumor Metabolism and Immune Microenvironment for Self-Reinforcing Photodynamic Immunotherapy
Authors: Shurong Qin, Qi Wang, Zhuangwei Zhang, Junhui Gu, Guanzhong He, Fei Zeng, Ruiyue Chen, Bangshun He, Yuzhen Wang, Meng Wang, Yujun Song
Journal: Journal of the American Chemical Society
PubMed ID: 41059938
Doi: 10.1021/jacs.5c10242
Products & Services: Recombinant Proteins   
ZBP1 pathway promotes tumor immunogenicity in thecombinationofanti-HER2therapyandepigenetic therapy
Authors: Qishan Wang, Zhihao Wu, Yuanqin Yang, Chao Yang, Haoran Deng, Xingyue Zhou, Shuting Xu, Lingling Wu, Xiaochuan Hong, Xueni Yu, Lu Lu, Liufu Deng
Journal: Cell Reports
Doi: 10.1016/j.celrep.2025.116314
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