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Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma

Authors: James M Cleary, Betty Rouaisnel, Antoine Daina, Srivatsan Raghavan, Lauren A Roller, Brandon M Huffman, Harshabad Singh, Patrick Y Wen, Nabeel Bardeesy, Vincent Zoete, Brian M Wolpin, Julie-Aurore Losman

Journal: NPJ Precis Oncol

PubMed ID: 36056177

Doi: 10.1038/s41698-022-00304-5

Products & Services: Custom Vector Construction

Respiratory Vaccination with Hemagglutinin Nanoliposomes Protects Mice from Homologous and Heterologous Strains of Influenza Virus

Authors: Zachary R Sia, Kevin Chiem, Wei-Chiao Huang, Amal Seffouh, Amir Teimouri Dereshgi, Tara Hogan, Joaquin Ortega, Bruce A Davidson, Luis Martinez-Sobrido, Jonathan F Lovell

Journal: J Virol

PubMed ID: 36106872

Doi: 10.1128/jvi.01006-22

Products & Services: Mutagenesis Services

Identification and assessment of TCR-T cells targeting an epitope conserved in SARS-CoV-2 variants for the treatment of COVID-19

Authors: Yipeng Ma , Fenglan Liu , Bin Li , Kaiqi Peng , Hong Zhou , You Xu , Dongjuan Qiao , Lijuan Deng , Geng Tian , Morten Nielsen , Mingjun Wang

Journal: Int Immunopharmacol

PubMed ID: 36201943

Doi: 10.1016/j.intimp.2022.109283

Products & Services: Peptide Synthesis

Antimicrobial Peptide Mechanism Studied by Scattering-Guided Molecular Dynamics Simulation

Authors: Robert Allsopp, Anna Pavlova, Tyler Cline, Aria M Salyapongse, Richard E Gillilan, Y Peter Di, Berthony Deslouches, Jeffery B Klauda, James C Gumbart, Stephanie Tristram-Nagle

Journal: J Phys Chem B

PubMed ID: 36067064

Doi: 10.1021/acs.jpcb.2c03193

Products & Services: Peptide Synthesis

A LILRB1 variant with a decreased ability to phosphorylate SHP-1 leads to autoimmune diseases

Authors: Thivaratana Sinthuwiwat, Supranee Buranapraditkun, Wuttichart Kamolvisit, Siraprapa Tongkobpetch, Wanna Chetruengchai, Chalurmpon Srichomthong, Adjima Assawapitaksakul, Chureerat Phokaew, Patipark Kueanjinda, Tanapat Palaga, Tadech Boonpiyathad, Kanya Suphapeetiporn, Nattiya Hirankarn, Vorasuk Shotelersuk

Journal: Sci Rep

PubMed ID: 36104364

Doi: 10.1038/s41598-022-19334-x

Products & Services: Mutagenesis Services

LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin

Authors: Yao Zhou , Danyang Li , Diyin Li , Aizhong Chen , Liuqing He , Jianhua Luo , Liang Tao

Journal: Commun Biol .

PubMed ID: 36064583

Doi: 10.1038/s42003-022-03873-0

Products & Services: Gene Synthesis

High-efficiency recombinant protein purification using mCherry and YFP nanobody affinity matrices

Authors: Anh T Q Cong, Taylor L Witter, Matthew J Schellenberg

Journal: Protein Sci

PubMed ID: 36040252

Doi: 10.1002/pro.4383

Products & Services: Plasmid DNA Preparation

Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis

Authors: Yong Chen, Zhuyin Wu, Shijia Huang, Xiaoxia Wang, Sijia He, Lin Liu, Yurong Hu, Li Chen, Peng Chen, Songzi Liu, Shengqi He, Bo Shan, Ling Zheng, Sheng-Zhong Duan, Zhiyin Song, Lei Jiang, Qiong A Wang, Zhenji Gan, Bao-Liang Song, Jianmiao Liu, Liangyou Rui, Mengle Shao, Yong Liu

Journal: Nat Metab

PubMed ID: 36123394

Doi: 10.1038/s42255-022-00631-8

Products & Services: Gene Synthesis

Molecular advances to study the function, evolution and spectral tuning of arthropod visual opsins

Authors: Marjorie A Liénard, Wendy A Valencia-Montoya, Naomi E Pierce

Journal: Philos Trans R Soc Lond B Biol Sci

PubMed ID: 36058235

Doi: 10.1098/rstb.2021.0279

Products & Services: Codon Optimization

Generation and characterization of mouse monoclonal antibodies against the VP4 protein of group A human rotaviruses

Authors: Yuanjun Zeng, Feibo Song, Guoxing Luo, Han Yang, Cao Li, Wei Liu, Tingdong Li, Shiyin Zhang, Yingbin Wang, Chenghao Huang, Shengxiang Ge, Jun Zhang, Ningshao Xia

Journal: Antiviral Res

PubMed ID: 36152816

Doi: 10.1016/j.antiviral.2022.105407

Products & Services: Recombinant Antibody Expression