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Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma

Authors: Xiaoyu Liu, Jingying Zhou, Haoran Wu, Shufen Chen, Lingyun Zhang, Wenshu Tang, Liang Duan, Ying Wang, Eleanor McCabe, Mengying Hu, Zhuo Yu, Hanzhuang Liu, Chung Hang Jonathan Choi, Joseph Jao-Yiu Sung, Leaf Huang, Rihe Liu, Alfred Sze-Lok Cheng

Journal: Mol Ther

PubMed ID: 36146933

Doi: 10.1016/j.ymthe.2022.09.012

Products & Services: Protein and Antibody Isolation

Delivery of ceramide phosphoethanolamine lipids to the cleavage furrow through the endocytic pathway is essential for male meiotic cytokinesis

Authors: Govind Kunduri, Si-Hung Le, Valentina Baena, Nagampalli Vijaykrishna, Adam Harned, Kunio Nagashima, Daniel Blankenberg, Izumi Yoshihiro, Kedar Narayan, Takeshi Bamba, Usha Acharya, Jairaj K Acharya

Journal: PLoS Biol

PubMed ID: 36170207

Doi: 10.1371/journal.pbio.3001599

Products & Services: Custom Vector Construction

Variant-specific changes in RAC3 function disrupt corticogenesis in neurodevelopmental phenotypes

Authors: Marcello Scala, Masashi Nishikawa, Hidenori Ito, Hidenori Tabata, Tayyaba Khan, Andrea Accogli, Laura Davids, Anna Ruiz, Pietro Chiurazzi, Gabriella Cericola, Björn Schulte, Kristin G Monaghan, Amber Begtrup, Annalaura Torella, Michele Pinelli, Anne Sophie Denommé-Pichon, Antonio Vitobello, Caroline Racine, Maria Margherita Mancardi, Courtney Kiss, Andrea Guerin, Wendy Wu, Elisabeth Gabau Vila, Bryan C Mak, Julian A Martinez-Agosto, Michael B Gorin, Bugrahan Duz, Yavuz Bayram, Claudia M B Carvalho, Jaime E Vengoechea, David Chitayat, Tiong Yang Tan, Bert Callewaert, Bernd Kruse, Lynne M Bird, Laurence Faivre, Marcella Zollino, Saskia Biskup, Pasquale Striano, Vincenzo Nigro, Mariasavina Severino, Valeria Capra, Gregory Costain, Koh Ichi Nagata

Journal: Brain

PubMed ID: 35851598

Doi: 10.1093/brain/awac106

Products & Services: Custom Vector Construction

Farnesyl pyrophosphate compartmentalization in the green microalga Chlamydomonas reinhardtii during heterologous (E)-α-bisabolene production

Authors: Julian Wichmann, Annibel Eggert, Liam D H Elbourne, Ian T Paulsen, Kyle J Lauersen, Olaf Kruse

Journal: Microb Cell Fact

PubMed ID: 36104783

Doi: 10.1186/s12934-022-01910-5

Products & Services: Gene Synthesis

Modification of the HLA-A*24:02 Peptide Binding Pocket Enhances Cognate Peptide-Binding Capacity and Antigen-Specific T Cell Activation

Authors: Kenji Murata, Dalam Ly, Hiroshi Saijo, Yukiko Matsunaga, Kenji Sugata, Fumie Ihara, Daisuke Oryoji, Yota Ohashi, Kayoko Saso, Chung-Hsi Wang, Evey Y F Zheng, Brian D Burt, Marcus O Butler, Naoto Hirano

Journal: J Immunol

PubMed ID: 36165170

Doi: 10.4049/jimmunol.2200305

Products & Services: Peptide Synthesis

Comparison of SARS-CoV-2 spike antibody quantitative titer reporting using the World Health Organization International Standard Units by four commercial assays

Authors: Ran Zhuo, Carmen Charlton, Sabrina Plitt, L Alexa Thompson, Sheila Braun, Jacqueline Day, Carla Osiowy, Graham Tipples, Jamil N Kanji

Journal: J Clin Virol

PubMed ID: 36108404

Doi: 10.1016/j.jcv.2022.105292

Truncated Tau caused by intron retention is enriched in Alzheimer's disease cortex and exhibits altered biochemical properties

Authors: Zhen-Kai Ngian, Yow-Yong Tan, Ching-Thong Choo, Wei-Qi Lin, Chao-Yong Leow, Shan-Jie Mah, Mitchell Kim-Peng Lai, Christopher Li-Hsian Chen, Chin-Tong Ong

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36067305

Doi: 10.1073/pnas.2204179119

Products & Services: Catalog Antibodies

Reverse Transcription-Loop-Mediated Isothermal Amplification-CRISPR-Cas13a Technology as a Promising Diagnostic Tool for SARS-CoV-2

Authors: Concha Ortiz-Cartagena, Laura Fernández-García, Lucia Blasco, Olga Pacios, Inés Bleriot, María López, Rafael Cantón, María Tomás

Journal: Microbiol Spectr

PubMed ID: 36169448

Doi: 10.1128/spectrum.02398-22

Products & Services: Molecular Biology Tools

Host adaptation of codon usage in SARS-CoV-2 from mammals indicates potential natural selection and viral fitness

Authors: Yanan Fu, Yanping Huang, Jingjing Rao, Feng Zeng, Ruiping Yang, Huabing Tan, Zhixin Liu, Weixing Du, Long Liu

Journal: Arch Virol

PubMed ID: 36166106

Doi: 10.1007/s00705-022-05612-6

Products & Services: Mutagenesis Services

Context-based sensing of orthosomycin antibiotics by the translating ribosome

Authors: Kyle Mangano, James Marks, Dorota Klepacki, Chayan Kumar Saha, Gemma C Atkinson, Nora Vázquez-Laslop, Alexander S Mankin

Journal: Nat Chem Biol

PubMed ID: 36138139

Doi: 10.1038/s41589-022-01138-9

Products & Services: Protein and Antibody Isolation