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Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs

Authors: Canrong Wu, Chao Zhang, Sanshan Jin, James Jiqi Wang, Antao Dai, Jiuyin Xu, Heng Zhang, Xuemei Yang, Xinheng He, Qingning Yuan, Wen Hu, Youwei Xu, Mingwei Wang, Yi Jiang, Dehua Yang, H Eric Xu

Journal: Cell Discov

PubMed ID: 11962085

Doi: 10.1038/s41421-025-00779-z

Products & Services: Catalog Peptides

Metabolite-dependent m6A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration

Authors: Zhuo Li, Zhengnan Guo, Zhengmeng Yang, Boguang Yang, Yuan Hu, Xian Xie, Zhixian Zong, Zekun Chen, Kunyu Zhang, Pengchao Zhao, Gang Li, Xuefeng Yang, Liming Bian

Journal: Cell Rep

PubMed ID: 40272981

Doi: 10.1016/j.celrep.2025.115611

Products & Services: Peptide Synthesis

Shigella effector IpaH1.4 subverts host E3 ligase RNF213 to evade antibacterial immunity

Authors: Xindi Zhou, Huijing Zhang, Yaru Wang, Danni Wang, Zhiqiao Lin, Yuchao Zhang, Yubin Tang, Jianping Liu, Yu-Feng Yao, Yixiao Zhang & Lifeng Pan

Journal: Nature Communications

PubMed ID: 40164614

Doi: 10.1038/s41467-025-58432-y

Products & Services: Protein Electrophoresis and Western

Intranasal influenza virus-vectored vaccine offers protection against clade 2.3.4.4b H5N1 infection in small animal models

Authors: Ying Liu, Shaofeng Deng, Shuang Ren, Rachel Chun-Yee Tam, Siwen Liu, Anna Jinxia Zhang, Kelvin Kai-Wang To, Kwok-Yung Yuen, Honglin Chen & Pui Wang

Journal: Nature Communications

PubMed ID: 40169649

Doi: 10.1038/s41467-025-58504-z

Products & Services: Peptide Synthesis

True length of diverse capped RNA sequencing (TLDR-seq): 5′–3′-end sequencing of capped RNAs regardless of 3′-end status

Authors: Jamie Auxillos, Arnaud Stigliani, Christian Skov Vaagensø, William Garland, Adnan Muhammed Niazi, Eivind Valen, Torben Heick Jensen, Albin Sandelin

Journal: Nucleic Acids Research

PubMed ID: 40183637

Doi: 10.1093/nar/gkaf240

Products & Services: Molecular Biology Reagents

Architecture and conformational dynamics of the BAM-SurA holo insertase complex

Authors: Philippe A Lehner, Morris Degen, Roman P Jakob, Seyed Majed Modaresi, Morgane Callon, Björn M Burmann, Timm Maier, Sebastian Hiller

Journal: SCIENCE ADVANCES

PubMed ID: 40184469

Doi: 10.1126/sciadv.ads6094

Products & Services: Gene Synthesis

A naturally selected αβ T cell receptor binds HLA-DQ2 molecules without co-contacting the presented peptide

Authors: Jia Jia Lim, Claerwen M. Jones, Tiing Jen Loh, Hien Thy Dao, Mai T. Tran, Jason A. Tye-Din, Nicole L. La Gruta & Jamie Rossjohn

Journal: Nature Communications

PubMed ID: 40199885

Doi: 10.1038/s41467-025-58690-w

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DNA-guided transcription factor interactions extend human gene regulatory code

Authors: Zhiyuan Xie, Ilya Sokolov, Maria Osmala, Xue Yue, Grace Bower, J. Patrick Pett, Yinan Chen, Kai Wang, Ayse Derya Cavga, Alexander Popov, Sarah A. Teichmann, Ekaterina Morgunova, Evgeny Z. Kvon, Yimeng Yin & Jussi Taipale

Journal: Nature

PubMed ID: 40205063

Doi: 10.1038/s41586-025-08844-z

Products & Services: Gene Synthesis

Enzymatic oxidation of galacturonides from pectin breakdown contributes to stealth infection by Oomycota phytopathogens

Authors: Simone Turella, Cheng He, Lin Zhao, Sanchari Banerjee, Lauriane Plouhinec, Roseline Assiah Yao, Mette Christine Nørgaard Kejlstrup, Sacha Grisel, Yunjeong So, Bastien Annic, Mathieu Fanuel, Majid Haddad Momeni, Bastien Bissaro, Sebastian Meier, Jens Preben Morth, Suomeng Dong, Jean-Guy Berrin & Maher Abou Hachem

Journal: Nature Communications

PubMed ID: 40216756

Doi: 10.1038/s41467-025-58668-8

Products & Services: Gene Synthesis

The yeast CST and Polα/primase complexes act in concert to ensure proper telomere maintenance and protection

Authors: Kimberly Calugaru, Eun Young Yu, Sophie Huang, Nayim González-Rodríguez, Javier Coloma, Neal F Lue

Journal: Nucleic Acids Research

PubMed ID: 40245101

Doi: 10.1093/nar/gkaf245

Products & Services: Protein Electrophoresis and Western