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Regulating the N-oxidation selectivity of P450BM3 monooxygenases for N-heterocycles through computer-assisted structure-guided design

Authors: Liu Yang, Zhongji Pu, Jianping Wu, Xiaofeng Liu, Zhe Wang, Haoran Yu, Liuwei Wang, Yan Meng, Gang Xu, Lirong Yang, Wenlong Zheng

Journal: Nature Communications

PubMed ID: 40659637

Doi: 10.1038/s41467-025-61773-3

Products & Services: Protein Electrophoresis and Western

Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity

Authors: Tao Jiang, Shuaiyang Jing, Haojun Li, Bao Xiao, Jiahui Jin, Xiu Sun, Juan Wang, Jing Liang, Tongze Cai, Huili Hu, Meilan Wei, Xuanrui Zhong, Yang Ji, Peng George Wang, Jianlong Zhou

Journal: Advanced Science

PubMed ID: 40652522

Doi: 10.1002/advs.202417205

Products & Services: PCR Cloning and Subcloning

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

Authors: Irafasha C Casmil, Josh J Friesen, Nuthan V Bathula, Anneke Strumpel, Chia Hao Ho, Ilana Guez, Kristen Y S Kong, Andrew J Varley, Shigeki J Miyake-Stoner, Parinaz Aliahmad, Nathaniel S Wang, Andrew J Geall, Anna K Blakney

Journal: Advanced Science

PubMed ID: 40650657

Doi: 10.1002/advs.202508907

Products & Services: Circular RNA synthesis

Single-dose avian influenza A(H5N1) Clade 2.3.4.4b hemagglutinin-Matrix-M® nanoparticle vaccine induces neutralizing responses in nonhuman primates

Authors: Nita Patel, Asma Rehman, Jessica F Trost, Rhonda Flores, Zach Longacre, Mimi Guebre-Xabier, Haixia Zhou, Bin Zhou, Kelsey Jacobson, Desheng Jiang, Xiaoyun Bai, Rafia Khatoon, Thomas Kort, James Norton, M Madhangi, Melinda Hersey, Ann M Greene, Filip Dubovsky, Gale Smith

Journal: Nature Communications

PubMed ID: 40681543

Doi: 10.1038/s41467-025-61964-y

Products & Services: Gene Synthesis

Potentiating the Efficacy of mRNA Vaccines through NIR-II Imaging-Guided Precise Vaccination

Authors: Mengfei Li, Xue Zheng, Xinyang Yu, Shaolong Qi, Shoujun Zhu, Guocan Yu, Songling Zhang

Journal: Advanced Science

PubMed ID: 40681479

Doi: 10.1002/advs.202413014

Products & Services: Peptide Synthesis

API5 Phosphorylation Promotes Antiviral Immunity by Inhibiting Degradation of Cytosolic RNA Sensor RLRs

Authors: Tingjuan Deng, Jianan Xu, Linglong Qin, Xingbo Wang, Chenhe Lu, Yanming Huang, Da Liu, Yan Yan, Weiren Dong, Pinglong Xu, Jiyong Zhou

Journal: Advanced Science

PubMed ID: 40641422

Doi: 10.1002/advs.202505479

Products & Services: Protein and Antibody Isolation

Regulation of inflammatory responses by pH-dependent transcriptional condensates

Authors: Zhongyang Wu, Scott D Pope, Nasiha S Ahmed, Diana L Leung, Yu Hong, Stephanie Hajjar, Cathleen Krabak, Zhe Zhong, Krishnan Raghunathan, Qiuyu Yue, Diya M Anand, Elizabeth B Kopp, Daniel Okin, Weiyi Ma, Ivan Zanoni, Jonathan C Kagan, Jay R Thiagarajah, Diana C Hargreaves, Ruslan Medzhitov, Xu Zhou

Journal: Cell

PubMed ID: 40680734

Doi: 10.1016/j.cell.2025.06.033

Products & Services: Gene Synthesis

Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition

Authors: Yiru Wang, Lixia Zhao, Yi Zhang, Xiuxia Gao, Yannan Wang, Wenping Shi, Roger D Kornberg, Heqiao Zhang

Journal: Cell

PubMed ID: 40628260

Doi: 10.1016/j.cell.2025.06.017

Products & Services: Codon Optimization

Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics

Authors: M Alejandra Tortorici, Annette Choi, Cecily A Gibson, Jimin Lee, Jack T Brown, Cameron Stewart, Anshu Joshi, Sheri Harari, Isabelle Willoughby, Catherine Treichel, Elizabeth M Leaf, Jesse D Bloom, Neil P King, Christine Tait-Burkard, Gary R Whittaker, David Veesler

Journal: Nature

PubMed ID: 40634609

Doi: 10.1038/s41586-025-09155-z

Products & Services: Gene Synthesis

Biohybrid-based pyroelectric bio-denitrification driven by temperature fluctuations

Authors: Jie Ye, Shuhui Wang, Chaohui Yang, Zhenhao Zuo, Wenzhi Gu, Baogang Zhang, Shungui Zhou

Journal: Nature Communications

PubMed ID: 40595581

Doi: 10.1038/s41467-025-60908-w

Products & Services: Protein Electrophoresis and Western