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RGS12 is a novel tumor suppressor in osteosarcoma that inhibits YAP-TEAD1-Ezrin signaling

Authors: Yang Li, Min Liu, Shuting Yang, Ashley M Fuller, T S Karin Eisinger-Mathason, Shuying Yang

Journal: Oncogene

PubMed ID: 33686240

Doi: 10.1038/s41388-020-01599-z

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Functional elucidation of TfuA in peptide backbone thioamidation

Authors: Andi Liu, Yuanyuan Si, Shi-Hui Dong, Nilkamal Mahanta, Haley N Penkala, Satish K Nair, Douglas A Mitchell

Journal: Nat Chem Biol

PubMed ID: 33707784

Doi: 10.1038/s41589-021-00771-0

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Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling

Authors: Ross A Robinson, Samuel C Griffiths, Lieke L van de Haar, Tomas Malinauskas, Eljo Y van Battum, Pavol Zelina, Rebekka A Schwab, Dimple Karia, Lina Malinauskaite, Sara Brignani, Marleen H van den Munkhof, Özge Düdükcü, Anna A De Ruiter, Dianne M A Van den Heuvel, Benjamin Bishop, Jonathan Elegheert, A Radu Aricescu, R Jeroen Pasterkamp, Christian Siebold

Journal: Cell

PubMed ID: 33740419

Doi: 10.1016/j.cell.2021.02.045

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Y06014 is a selective BET inhibitor for the treatment of prostate cancer

Authors: Tian-Bang Wu, Qiu-Ping Xiang, Chao Wang, Chun Wu, Cheng Zhang, Mao-Feng Zhang, Zhao-Xuan Liu, Yan Zhang, Lin-Jiu Xiao, Yong Xu

Journal: Acta Pharmacol Sin

PubMed ID: 33654218

Doi: 10.1038/s41401-021-00614-7

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OMN6 a novel bioengineered peptide for the treatment of multidrug resistant Gram negative bacteria

Authors: Shira Mandel, Janna Michaeli, Noa Nur, Isabelle Erbetti, Jonathan Zazoun, Livia Ferrari, Antonio Felici, Moshe Cohen-Kutner, Niv Bachnoff

Journal: Sci Rep

PubMed ID: 33758343

Doi: 10.1038/s41598-021-86155-9

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Suppression of aggregate and amyloid formation by a novel intrinsically disordered region in metazoan Hsp110 chaperones

Authors: Unekwu M Yakubu, Kevin A Morano

Journal: J Biol Chem

PubMed ID: 33753171

Doi: 10.1016/j.jbc.2021.100567

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Structural determinants driving the binding process between PDZ domain of wild type human PALS1 protein and SLiM sequences of SARS-CoV E proteins

Authors: Ettore Lo Cascio, Angelo Toto, Gabriele Babini, Flavio De Maio, Maurizio Sanguinetti, Alvaro Mordente, Stefano Della Longa, Alessandro Arcovito

Journal: Comput Struct Biotechnol J

PubMed ID: 33758649

Doi: 10.1016/j.csbj.2021.03.014

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Exploration of benzofuran-based compounds as potent and selective Plasmodium falciparum glycogen synthase kinase-3 (PfGSK-3) inhibitors

Authors: Chantalle Moolman, Rencia van der Sluis, Richard M Beteck, Lesetja J Legoabe

Journal: Bioorg Chem

PubMed ID: 33813310

Doi: 10.1016/j.bioorg.2021.104839

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Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

Authors: Alexandra C Walls, Marcos C Miranda, Minh N Pham, Alexandra Schäfer, Allison Greaney, Prabhu S Arunachalam, Mary-Jane Navarro, M Alejandra Tortorici, Kenneth Rogers, Megan A O'Connor, Lisa Shireff, Douglas E Ferrell, Natalie Brunette, Elizabeth Kepl, John Bowen, Samantha K Zepeda, Tyler Starr, Ching-Lin Hsieh, Brooke Fiala, Samuel Wrenn, Deleah Pettie, Claire Sydeman, Max Johnson, Alyssa Blackstone, Rashmi Ravichandran, Cassandra Ogohara, Lauren Carter, Sasha W Tilles, Rino Rappuoli, Derek T O'Hagan, Robbert Van Der Most, Wesley C Van Voorhis, Jason S McLellan, Harry Kleanthous, Timothy P Sheahan, Deborah H Fuller, Francois Villinger, Jesse Bloom, Bali Pulendran, Ralph Baric, Neil King, David Veesler

Journal: biorxiv

PubMed ID: 33758839

Doi: 10.1101/2021.03.15.435528

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Stabilization of Damaged Articular Cartilage with Hydrogel-Mediated Reinforcement and Sealing

Authors: Jay M Patel, Claudia Loebel, Kamiel S Saleh, Brian C Wise, Edward D Bonnevie, Liane M Miller, James L Carey, Jason A Burdick, Robert L Mauck

Journal: Adv Healthc Mater

PubMed ID: 33738988

Doi: 10.1002/adhm.202100315

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