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Adult astrocytes from reptiles are resistant to proinflammatory activation via sustaining Vav1 expression

Authors: Nan Du, Hui Li, Chunshuai Sun, Bingqiang He, Ting Yang, Honghua Song, Yingjie Wang, Yongjun Wang

Journal: J Biol Chem

PubMed ID: 33705794

Doi: 10.1016/j.jbc.2021.100527

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Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria

Authors: Joseph R Francica, Wei Shi, Gwo-Yu Chuang, Steven J Chen, Lais Da Silva Pereira, S Katie Farney, Barbara J Flynn, Li Ou, Tyler Stephens, Yaroslav Tsybovsky, Lawrence T Wang, Alexander Anderson, Zoltan Beck, Marlon Dillon, Azza H Idris, Nicholas Hurlburt, Tracy Liu, Baoshan Zhang, Carl R Alving, Gary R Matyas, Marie Pancera, John R Mascola, Peter D Kwong, Robert A Seder

Journal: Vaccines (Basel)

PubMed ID: 33803622

Doi: 10.3390/vaccines9030272

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The Crystal Structure of Calmodulin Bound to the Cardiac Ryanodine Receptor (RyR2) at Residues Phe4246-Val4271 Reveals a Fifth Calcium Binding Site

Authors: Qinhong Yu, David E Anderson, Ramanjeet Kaur, Andrew J Fisher, James B Ames

Journal: Biochemistry

PubMed ID: 33754699

Doi: 10.1021/acs.biochem.1c00152

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Soluble Spike DNA Vaccine Provides Long-Term Protective Immunity against SARS-CoV-2 in Mice and Nonhuman Primates

Authors: Yong Bok Seo, You Suk Suh, Ji In Ryu, Hwanhee Jang, Hanseul Oh, Bon-Sang Koo, Sang-Hwan Seo, Jung Joo Hong, Manki Song, Sung-Joo Kim, Young Chul Sung

Journal: Vaccines (Basel)

PubMed ID: 33804981

Doi: 10.3390/vaccines9040307

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RGS12 is a novel tumor suppressor in osteosarcoma that inhibits YAP-TEAD1-Ezrin signaling

Authors: Yang Li, Min Liu, Shuting Yang, Ashley M Fuller, T S Karin Eisinger-Mathason, Shuying Yang

Journal: Oncogene

PubMed ID: 33686240

Doi: 10.1038/s41388-020-01599-z

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Functional elucidation of TfuA in peptide backbone thioamidation

Authors: Andi Liu, Yuanyuan Si, Shi-Hui Dong, Nilkamal Mahanta, Haley N Penkala, Satish K Nair, Douglas A Mitchell

Journal: Nat Chem Biol

PubMed ID: 33707784

Doi: 10.1038/s41589-021-00771-0

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Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling

Authors: Ross A Robinson, Samuel C Griffiths, Lieke L van de Haar, Tomas Malinauskas, Eljo Y van Battum, Pavol Zelina, Rebekka A Schwab, Dimple Karia, Lina Malinauskaite, Sara Brignani, Marleen H van den Munkhof, Özge Düdükcü, Anna A De Ruiter, Dianne M A Van den Heuvel, Benjamin Bishop, Jonathan Elegheert, A Radu Aricescu, R Jeroen Pasterkamp, Christian Siebold

Journal: Cell

PubMed ID: 33740419

Doi: 10.1016/j.cell.2021.02.045

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Y06014 is a selective BET inhibitor for the treatment of prostate cancer

Authors: Tian-Bang Wu, Qiu-Ping Xiang, Chao Wang, Chun Wu, Cheng Zhang, Mao-Feng Zhang, Zhao-Xuan Liu, Yan Zhang, Lin-Jiu Xiao, Yong Xu

Journal: Acta Pharmacol Sin

PubMed ID: 33654218

Doi: 10.1038/s41401-021-00614-7

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Structural determinants driving the binding process between PDZ domain of wild type human PALS1 protein and SLiM sequences of SARS-CoV E proteins

Authors: Ettore Lo Cascio, Angelo Toto, Gabriele Babini, Flavio De Maio, Maurizio Sanguinetti, Alvaro Mordente, Stefano Della Longa, Alessandro Arcovito

Journal: Comput Struct Biotechnol J

PubMed ID: 33758649

Doi: 10.1016/j.csbj.2021.03.014

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Suppression of aggregate and amyloid formation by a novel intrinsically disordered region in metazoan Hsp110 chaperones

Authors: Unekwu M Yakubu, Kevin A Morano

Journal: J Biol Chem

PubMed ID: 33753171

Doi: 10.1016/j.jbc.2021.100567

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