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Mutation-induced dimerization of transforming growth factor-β-induced protein (TGFBIp) may drive protein aggregation in granular corneal dystrophy

Authors: Nadia Sukusu Nielsen, Trine A F Gadeberg, Ebbe Toftgaard Poulsen, Seandean Lykke Harwood, Christian E Weberskov, Jan Skov Pedersen, Gregers R Andersen, Jan J Enghild

Journal: J Biol Chem

PubMed ID: 34097874

Doi: 10.1016/j.jbc.2021.100858

Products & Services: Mammalian Expression

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

Authors: Euphemia Leung, Jinal Patel, Jennifer A Hollywood, Ayesha Zafar, Petr Tomek, David Barker, Lisa I Pilkington, Michelle van Rensburg, Ries J Langley, Nuala A Helsby, Christopher J Squire, Bruce C Baguley, William A Denny, Jóhannes Reynisson, Ivanhoe K H Leung

Journal: Oncol Ther

PubMed ID: 34159519

Doi: 10.1007/s40487-021-00158-0

Products & Services: Mammalian Expression

Targeting ribosomal G-quadruplexes with naphthalene-diimides as RNA polymerase I inhibitors for colorectal cancer treatment

Authors: Victoria Sanchez-Martin, David A Schneider, Matilde Ortiz-Gonzalez, Ana Soriano-Lerma, Angel Linde-Rodriguez, Virginia Perez-Carrasco, Jose Gutierrez-Fernandez, Marta Cuadros, Carlos González, Miguel Soriano, Jose A Garcia-Salcedo

Journal: Cell Chem Biol

PubMed ID: 34166611

Doi: 10.1016/j.chembiol.2021.05.021

Products & Services: Mammalian Expression

Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection

Authors: Allison J Greaney, Andrea N Loes, Lauren E Gentles, Katharine H D Crawford, Tyler N Starr, Keara D Malone, Helen Y Chu, Jesse D Bloom

Journal: Sci Transl Med

PubMed ID: 34103407

Doi: 10.1126/scitranslmed.abi9915

Products & Services: Mammalian Expression

Analysis of the Evolution of Pandemic Influenza A(H1N1) Virus Neuraminidase Reveals Entanglement of Different Phenotypic Characteristics

Authors: Meiling Dai, Wenjuan Du, Carles Martínez-Romero, Tim Leenders, Tom Wennekes, Guus F Rimmelzwaan, Frank J M van Kuppeveld, Ron A M Fouchier, Adolfo Garcia-Sastre, Erik de Vries, Cornelis A M de Haan

Journal: MBio

PubMed ID: 33975931

Doi: 10.1128/mBio.00287-21

Products & Services: Mammalian Expression

Metabolic reprogramming of terminally exhausted CD8 T cells by IL-10 enhances anti-tumor immunity

Authors: Yugang Guo, Yu-Qing Xie, Min Gao, Yang Zhao, Fabien Franco, Mathias Wenes, Imran Siddiqui, Alessio Bevilacqua, Haiping Wang, Hanshuo Yang, Bing Feng, Xin Xie, Catherine M Sabatel, Benjamin Tschumi, Amphun Chaiboonchoe, Yuxi Wang, Weimin Li, Weihua Xiao, Werner Held, Pedro Romero, Ping-Chih Ho, Li Tang

Journal: Nat Immunol

PubMed ID: 34031618

Doi: 10.1038/s41590-021-00940-2

Products & Services: Mammalian Expression

Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain-based vaccine candidate, RBD219-N1C1

Authors: Jungsoon Lee, Zhuyun Liu, Wen-Hsiang Chen, Junfei Wei, Rakhi Kundu, Rakesh Adhikari, Joanne Altieri Rivera, Portia M Gillespie, Ulrich Strych, Bin Zhan, Peter J Hotez, Maria Elena Bottazzi

Journal: Appl Microbiol Biotechnol

PubMed ID: 33959781

Doi: 10.1007/s00253-021-11281-3

Products & Services: Mammalian Expression

Delayed production of neutralizing antibodies correlates with fatal COVID-19

Authors: Carolina Lucas, Jon Klein, Maria E Sundaram, Feimei Liu, Patrick Wong, Julio Silva, Tianyang Mao, Ji Eun Oh, Subhasis Mohanty, Jiefang Huang, Maria Tokuyama, Peiwen Lu, Arvind Venkataraman, Annsea Park, Benjamin Israelow, Chantal B F Vogels, M Catherine Muenker, C-Hong Chang, Arnau Casanovas-Massana, Adam J Moore, Joseph Zell, John B Fournier, Anne L Wyllie, Melissa Campbell, Alfred Lee, Hyung J Chun, Nathan D Grubaugh, Wade L Schulz, Shelli Farhadian, Charles Dela Cruz, Aaron M Ring, Albert C Shaw, Adam V Wisnewski, Inci Yildirim, Albert I Ko, Saad Omer, Akiko Iwasaki

Journal: Nat Med

PubMed ID: 33953384

Doi: 10.1038/s41591-021-01355-0

Products & Services: Mammalian Expression

Ovalbumin Antigen-Specific Activation of Human T Cell Receptor Closely Resembles Soluble Antibody Stimulation as Revealed by BOOST Phosphotyrosine Proteomics.

Authors: Chua XY,Salomon A

Journal: Journal of proteome research

PubMed ID: 34018748

Doi: 10.1021/acs.jproteome.1c00239

Products & Services: Mammalian Expression

Broad and potently neutralizing monoclonal antibodies isolated from human survivors of New World hantavirus infection

Authors: Taylor B Engdahl, Natalia A Kuzmina, Adam J Ronk, Chad E Mire, Matthew A Hyde, Nurgun Kose, Matthew D Josleyn, Rachel E Sutton, Apoorva Mehta, Rachael M Wolters, Nicole M Lloyd, Francisca R Valdivieso, Thomas G Ksiazek, Jay W Hooper, Alexander Bukreyev, James E Crowe

Journal: Cell Rep

PubMed ID: 33951434

Doi: 10.1016/j.celrep.2021.109086

Products & Services: Mammalian Expression