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Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors

Authors: James C. Tarr; James M. Salovich; Martin Aichinger; KyuOk Jeon; Nagarathanam Veerasamy; John L. Sensintaffar; Heribert Arnhof; Matthias Samwer; Plamen P. Christov; Kwangho Kim; Tobias Wunberg; Norbert Schweifer; Francesca Trapani; Allison Arnold; Florian Martin; Bin Zhao; Nagaraju Miriyala; Danielle Sgubin; Stuart Fogarty; William J. Moore; Gordon M. Stott; Edward T. Olejniczak; Harald Engelhardt; Dorothea Rudolph; Taekyu Lee; Darryl B. McConnell; Stephen W. Fesik

Journal: Journal of Medicinal Chemistry

PubMed ID: 39102508

Doi: 10.1021/acs.jmedchem.4c01188

Products & Services: Peptide Synthesis

Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors

Journal: Journal of Medicinal Chemistry

PubMed ID: 39102508

Doi: 10.1021/acs.jmedchem.4c01188

Products & Services: Peptide Synthesis

Multi-Epitope Vaccine Design Using an Immunoinformatic Approach for SARS-CoV-2

Authors: Ye Feng, Haiping Jiang, Min Qiu, Liang Liu, Shengmei Zou, Yun Li, Qianpeng Guo, Ning Han, Yingqiang Sun, Kui Wang, Lantian Lu, Xinlei Zhuang, Shanshan Zhang, Shuqing Chen, Fan Mo

Journal: Pathogens

PubMed ID: 34208061

Doi: 10.3390/pathogens10060737

Products & Services: Peptide Synthesis

Yeast display of MHC-II enables rapid identification of peptide ligands from protein antigens (RIPPA)

Authors: Rongzeng Liu, Wei Jiang, Elizabeth D Mellins

Journal: Cell Mol Immunol

PubMed ID: 34117370

Doi: 10.1038/s41423-021-00717-5

Products & Services: Peptide Synthesis

Catalytic Dyad Residues His41 and Cys145 Impact the Catalytic Activity and Overall Conformational Fold of the Main SARS-CoV-2 Protease 3-Chymotrypsin-Like Protease

Authors: Juliana C Ferreira, Samar Fadl, Adrian J Villanueva, Wael M Rabeh

Journal: Front Chem

PubMed ID: 34249864

Doi: 10.3389/fchem.2021.692168

Products & Services: Peptide Synthesis

The interplay of self-assembly and target binding in centrin 1 from Toxoplasma gondii

Authors: Carolina Conter, Luca Bombardi, Marco Pedretti, Filippo Favretto, Adele Di Matteo, Paola Dominici, Alessandra Astegno

Journal: Biochem J

PubMed ID: 34114596

Doi: 10.1042/BCJ20210295

Products & Services: Peptide Synthesis

Thrombus-targeted nanoparticles for thrombin-triggered thrombolysis and local inflammatory microenvironment regulation

Authors: Huijuan Zhang, Hongyan Qu, Qingqing He, Linyu Gao, Hongling Zhang, Yongfu Wang, Zhenzhong Zhang, Lin Hou

Journal: J Control Release

PubMed ID: 34214595

Doi: 10.1016/j.jconrel.2021.06.043

Products & Services: Peptide Synthesis

Identification of a Glypican-3 binding peptide from a phage-displayed peptide library for PET imaging of hepatocellular carcinoma

Authors: Jiayao Yan, Xiaoxiao Yu, Xiaotong Chen, Fangcen Liu, Fangjun Chen, Naiqing Ding, Lixia Yu, Fanyan Meng, Jie Shen, Jia Wei and Baorui Liu

Journal: Frontiers in Oncology

PubMed ID: 34150644

Products & Services: Peptide Synthesis

Artificial Protein Coronas Enable Controlled Interaction with Corneal Epithelial Cells: New Opportunities for Ocular Drug Delivery

Authors: Carlo Astarita, Sara Palchetti, Mina Massaro-Giordano, Marina Di Domenico, Francesco Petrillo, Silvia Boffo, Giulio Caracciolo, Antonio Giordano

Journal: Pharmaceutics

PubMed ID: 34204664

Doi: 10.3390/pharmaceutics13060867

Products & Services: Peptide Synthesis

Identification of naturally processed Zika virus peptides by mass spectrometry and validation of memory T cell recall responses in Zika convalescent subjects

Authors: Stephen N Crooke, Inna G Ovsyannikova, Richard B Kennedy, Gregory A Poland

Journal: PLoS ONE

PubMed ID: 34077451

Doi: 10.1371/journal.pone.0252198

Products & Services: Peptide Synthesis