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Functional and Mechanistic Investigation of a Distinct DUF6895 Family Epimerase Involved in Lasso Peptide Modification

Authors: Menghan Shi, Yuwei Duan, Shao-Yang Hou, Liangxu Xie, Weifeng Sun, Liubin Feng, Youming Zhang, Xiaoying Bian, and Guannan Zhong

Journal: ACS Catalysis

Doi: 10.1021/acscatal.5c08590

Products & Services: Peptide Synthesis

Unconventional binding of calmodulin to CHK2 kinase inhibits catalytic activity

Authors: Christopher R Horne, Tingting Wang, Samuel N Young, Toby A Dite, Hunter G Nyvall, Sushant Suresh, Katherine A Davies, Abner Gonzalez Castro, Vineet Vaibhav, Lucy J Mather, Laura F Dagley, Matthew J Belousoff, Gerard Manning, Anthony R Means, John E Burke, Janni Petersen, John W Scott, James M Murphy

Journal: The Biochemical journal

PubMed ID: 41003242

Doi: doi.org/10.1042/BCJ20253431

Products & Services: Peptide Synthesis

OMP16-targeting monoclonal antibodies H4 and E6 reveal essential linear epitopes for Brucella immunoprotection

Authors: Yunyi Zhai, Kaihui Sun, Ye Yuan, Xiaofang Liu, Gaowa Wudong, Yuanhao Yang, Shuan Qu, Yaxin Li, Dong Zhou, Wei Liu, Yaping Jin, Aihua Wang

Journal: International Journal of Biological Macromolecules

PubMed ID: 41448303

Doi: 10.1016/j.ijbiomac.2025.149881

Products & Services: Bacterial Expression Mutagenesis Services Peptide Synthesis

Human Substance P Interactions with G Protein-Coupled Receptor NK1R Observed by NMR in Solution

Authors: Haoyi Ge, Lingyun Yang, Changran Chen, Yuxin Xu, Dongsheng Liu, Kurt Wüthrich

Journal: Journal of the American Chemical Society

PubMed ID: 41264783

Doi: doi.org/10.1021/jacs.5c12553

Products & Services: Peptide Synthesis

ROS-triggered self-assembling peptide hydrogel combining bacterial entrapment and intracellular penetration for Salmonella Typhimurium-induced enteritis therapy

Authors: Wenwen Meng, Hao Yang, Wenqian Zhang, Xueyan Li, Jiajun Sun, Ting Hu, Wei Li, Yaohong Zhu, Yong Wang, Xi Ma, Guiyan Yang, Jiufeng Wang

Journal: Chemical Engineering Journal

Doi: doi.org/10.1016/j.cej.2025.169392

Products & Services: Peptide Synthesis

Amplifying antigen-induced cellular responses with proximity labelling

Authors: Shuojun Li, Yinghui Men, Zihan Wang, Yingcheng Wu, Hao Sun, Mingyang Yin, Xinrui Fan, Guiyun Deng, Zhicheng Yang, Tiange Yang, Yudian Xiao, Hu Zhou, Guangchuan Wang, Jia Fan, Chenqi Xu, Qiang Gao, Shuo Han

Journal: Nature

PubMed ID: 40931066

Doi: 10.1038/s41586-025-09518-6. Online ahead of print.

Products & Services: Peptide Synthesis

A broadly neutralizing antibody recognizes a unique epitope with a signature motif common across coronaviruses

Authors: Lei Yan, Fulian Wang, Michelle Hill, Juliane Brun, Ze Liang, Xinyu Shi, Liangminghui Zhang, Xiuxiu He, Yu Li, Qianping Huang, Xuxue Dong, Huanzhen Liu, Yi Zhang, Lili Liu, Raymond A Dwek, Nicole Zitzmann, Aibin Liang, Guang Yang

Journal: Nature Communications

PubMed ID: 40813592

Doi: doi.org/10.1038/s41467-025-63101-1

Products & Services: Peptide Synthesis

A receptor antagonist counterbalances multiple systemin phytocytokines in tomato

Authors: Lei Wang, Louis-Philippe Maier, Nga Pham, Yan L Wang, Xu Wang, Andreas Schaller, Judith Fliegmann, Matthias Erb, Thomas Boller, Georg Felix

Journal: Cell

PubMed ID: 40845839

Doi: 10.1016/j.cell.2025.07.044

Products & Services: Peptide Synthesis

AMPGen: an evolutionary information-reserved and diffusion-driven generative model for de novo design of antimicrobial peptides

Authors: Shuwen Jin, Zihan Zeng, Xiyan Xiong, Baicheng Huang, Li Tang, Hongsheng Wang, Xiao Ma, Xiaochun Tang, Guoqing Shao, Xingxu Huang, Feng Lin

Journal: Communications Biology

PubMed ID: 40447738

Doi: 10.1038/s42003-025-08282-7

Products & Services: Peptide Synthesis

Retrograde transport of neurotrophin receptor TrkB-FL inducedby excitotoxicity regulates Golgi stability and is a target forstroke neuroprotection

Authors: Gema María Esteban-Ortega, Elena Torres-Campos, Margarita Díaz-Guerra

Journal: Cell death & disease

PubMed ID: 40883288

Doi: 10.1038/s41419-025-07990-6

Products & Services: Peptide Synthesis Protein and Antibody Isolation