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Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair

Authors: Oguz Bolgi, Maria Silva-Garcia, Breyan Ross, Esther Pilla, Vijayalakshmi Kari, Markus Killisch, Melanie Spitzner, Nadine Stark, Christof Lenz, Konstantin Weiss, Laura Donzelli, Mark D Gorrell, Marian Grade, Jan Riemer, Henning Urlaub, Matthias Dobbelstein, Robert Huber, Ruth Geiss-Friedlander

Journal: EMBO Reports

Doi: 10.15252/embr.202154136

Products & Services: Peptide Synthesis

SRC-3 deficiency prevents atherosclerosis development by decreasing endothelial ICAM-1 expression to attenuate macrophage recruitment

Authors: Wenbo Chen, Wuyang Zheng, Shixiao Liu, Qiang Su, Kangxi Ding, Ziguan Zhang, Ping Luo, Yong Zhang, Jianming Xu, Chundong Yu, Weihua Li, Zhengrong Huang

Journal: Int J Biol Sci

PubMed ID: 36263184

Doi: 10.7150/ijbs.74864

Products & Services: Peptide Synthesis

Herpes simplex virus lymphadenitis is associated with tumor reduction in a patient with chronic lymphocytic leukemia

Authors: Andres Chang, Anton M Sholukh, Andreas Wieland, David L Jaye, Mary Carrington, Meei-Li Huang, Hong Xie, Keith R Jerome, Pavitra Roychoudhury, Alexander L Greninger, Jean L Koff, Jonathon B Cohen, David M Koelle, Lawrence Corey, Christopher R Flowers, Rafi Ahmed

Journal: J Clin Invest

PubMed ID: 35862190

Doi: 10.1172/JCI161109

Products & Services: Peptide Synthesis

High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity

Authors: Rodrigo Vazquez-Lombardi, Johanna S Jung, Fabrice S Schlatter, Anna Mei, Natalia Rodrigues Mantuano, Florian Bieberich, Kai-Lin Hong, Jakub Kucharczyk, Edo Kapetanovic, Erik Aznauryan, Cédric R Weber, Alfred Zippelius, Heinz Läubli, Sai T Reddy

Journal: Immunity

PubMed ID: 36174557

Doi: 10.1016/j.immuni.2022.09.004

Products & Services: Peptide Synthesis

The SOS response-associated peptidase (SRAP) domain of YedK catalyzes ring opening of abasic sites and reversal of its DNA–protein cross-link

Authors: Katherine A Paulin , David Cortez , Brandt F Eichman

Journal: J Biol Chem

PubMed ID: 35934051

Doi: 10.1016/j.jbc.2022.102307

Products & Services: Peptide Synthesis

Mitochondrial derived peptide MOTS-c prevents the development of heart failure under pressure overload conditions in mice

Authors: Peng Zhong, Jianye Peng, Yewen Hu, Jun Zhang, Caijie Shen

Journal: J Cell Mol Med

PubMed ID: 36156853

Doi: 10.1111/jcmm.17551

Products & Services: Peptide Synthesis

Personalized neoantigen vaccine combined with PD-1 blockade increases CD8+ tissue-resident memory T-cell infiltration in preclinical hepatocellular carcinoma models

Authors: Hengkai Chen, Zhenli Li, Liman Qiu, Xiuqing Dong, Geng Chen, Yingjun Shi, Linsheng Cai, Wenhan Liu,Honghao Ye,Yang Zhou,Jiahe Ouyang, Zhixiong Cai and Xiaolong Liu

Journal: J Immunother Cancer

PubMed ID: 36113894

Doi: 10.1136/jitc-2021-004389

Products & Services: Peptide Synthesis

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein

Authors: Kailu Yang, Chuchu Wang, Alex J B Kreutzberger, Ravi Ojha, Suvi Kuivanen, Sergio Couoh-Cardel, Serena Muratcioglu, Timothy J Eisen, K Ian White, Richard G Held, Subu Subramanian, Kendra Marcus, Richard A Pfuetzner, Luis Esquivies, Catherine A Doyle, John Kuriyan, Olli Vapalahti, Giuseppe Balistreri, Tom Kirchhausen, Axel T Brunger

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36122200

Doi: 10.1073/pnas.2210990119

Products & Services: Peptide Synthesis

Structural and large-scale analysis unveil the intertwined paths promoting NMT-catalyzed lysine and glycine myristoylation

Authors: Frédéric Rivière , Cyril Dian , Rémi F Dutheil , Paul Monassa , Carmela Giglione , Thierry Meinnel

Journal: J Mol Biol

PubMed ID: 36181773

Doi: 10.1016/j.jmb.2022.167843

Products & Services: Peptide Synthesis

Small secreted peptides encoded on the wheat ( L) genome and their potential roles in stress responses

Authors: Dongdong Tian, Qi Xie, Zhichao Deng, Jin Xue, Wei Li, Zenglin Zhang, Yifei Dai, Bo Zheng, Tiegang Lu, Ive De Smet, Yongfeng Guo

Journal: Front Plant Sci

PubMed ID: 36212358

Doi: 10.3389/fpls.2022.1000297

Products & Services: Peptide Synthesis