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GLP1 alleviates oleic acid-propelled lipocalin-2 generation by tumor-infiltrating CD8+ T cells to reduce polymorphonuclear MDSC recruitment and enhances viral immunotherapy in pancreatic cancer

Authors: Jingyi Wu, Peng Qian, Yifeng Han, Chuning Xu, Mao Xia, Ping Zhan, Jiwu Wei, Jie Dong

Journal: Cellular & molecular immunology

PubMed ID: 39910336

Doi: 10.1038/s41423-025-01260-3

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Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits

Authors: Loϊc Binan, Aiping Jiang, Serwah A Danquah, Vera Valakh, Brooke Simonton, Jon Bezney, Robert T Manguso, Kathleen B Yates, Ralda Nehme, Brian Cleary, Samouil L Farhi

Journal: Cell

PubMed ID: 40081369

Doi: 10.1016/j.cell.2025.02.012

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Structural dynamics of DNA unwinding by a replicative helicase

Authors: Taha Shahid, Ammar U Danazumi, Muhammad Tehseen, Lubna Alhudhali, Alice R Clark, Christos G Savva, Samir M Hamdan, Alfredo De Biasio

Journal: Nature

PubMed ID: 40108462

Doi: 10.1038/s41586-025-08766-w

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Structural basis for the allosteric activation of Lon by the heat shock protein LarA

Authors: Hsiu-Jung Wang, Yun-Erh Kuan, Meng-Ru Ho, Chung-I Chang

Journal: Nature Communications

PubMed ID: 40044692

Doi: 10.1038/s41467-025-57482-6

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Enhancing Prime Editing Efficiency Through Modulation of Methylation on the Newly Synthesized DNA Strand and Prolonged Expression

Authors: Xiaosong Han, Xianghua Xu, Youcai Xiong, Guangxing Zhao, Ruigao He, Yinyu Su, Sheng Li, Changzhi Zhao, Xiaoning Xi, Yunxia Zhao, Xuewen Xu, Shengsong Xie, Heng Wang, Xinyun Li, Shuhong Zhao, Jinxue Ruan

Journal: Advanced Science

PubMed ID: 40051369

Doi: 10.1002/advs.202417790

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Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer

Authors: Xue Yang, Xiuquan Ma, Tianyue Zhao, David R Croucher, Elizabeth V Nguyen, Kimberley C Clark, Changyuan Hu, Sharissa L Latham, Charles Bayly-Jones, Bao V Nguyen, Srikanth Budnar, Sung-Young Shin, Lan K Nguyen, Thomas R Cotton, Anderly C Chüeh, Terry C C Lim Kam Sian, Margaret M Stratton, Andrew M Ellisdon, Roger J Daly

Journal: Nature Communications

PubMed ID: 39984440

Doi: 10.1038/s41467-025-57046-8

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Design of CoQ10 crops based on evolutionary history

Authors: Jing-Jing Xu, Yuan Lei, Xiao-Fan Zhang, Jian-Xu Li, Qiupeng Lin, Xiang-Dong Wu, Yu-Guo Jiang, Wenyi Zhang, Runtong Qian, Shu-Yi Xiong, Kuo Tan, Yu Jia, Qiang Zhou, Yan Jiang, Hang Fan, Yan-Bo Huang, Ling-Jian Wang, Ji-Yun Liu, Yu Kong, Qing Zhao, Lei Yang, Jinxing Liu, Yong-Hong Hu, Shuai Zhan, Caixia Gao, Xiao-Ya Chen

Journal: Cell

PubMed ID: 39952246

Doi: 10.1016/j.cell.2025.01.023

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Genetic regulation of TERT splicing affects cancer risk by altering cellular longevity and replicative potential

Authors: Oscar Florez-Vargas, Michelle Ho, Maxwell H Hogshead, Brenen W Papenberg, Chia-Han Lee, Kaitlin Forsythe, Kristine Jones, Wen Luo, Kedest Teshome, Cornelis Blauwendraat, Kimberly J Billingsley, Mikhail Kolmogorov, Melissa Meredith, Benedict Paten, Raj Chari, Chi Zhang, John S Schneekloth, Mitchell J Machiela, Stephen J Chanock, Shahinaz M Gadalla, Sharon A Savage, Sam M Mbulaiteye, Ludmila Prokunina-Olsson

Journal: Nature Communications

PubMed ID: 39956830

Doi: 10.1038/s41467-025-56947-y

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ABC transporter activity is affected by the size of lipid nanodiscs

Authors: Annabella Nouel Barreto, Luis G Cuello, Maria E Zoghbi

Journal: FEBS letters

PubMed ID: 39748569

Doi: 10.1002/1873-3468.15096

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Synthetic lethality of mRNA quality control complexes in cancer

Authors: Vivian Prindle, Adam E Richardson, Kimberly R Sher, Sarah Kongpachith, Kaitlin Kentala, Sakina Petiwala, Dong Cheng, Deborah Widomski, Phuong Le, Maricel Torrent, Anlu Chen, Stephen Walker, Marianne B Palczewski, Diya Mitra, Vlasios Manaves, Xu Shi, Charles Lu, Stephanie Sandoval, Zoltan Dezso, F Gregory Buchanan, Daniel Verduzco, Brian Bierie, Jonathan A Meulbroek, William N Pappano, Joshua P Plotnik

Journal: Nature

PubMed ID: 39910291

Doi: 10.1038/s41586-024-08398-6

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