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Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response

Authors: Kishu Ranjan, Matija Hedl, Saloni Sinha, Xuchen Zhang, Clara Abraham

Journal: J Clin Invest

PubMed ID: 34623328

Doi: 10.1172/JCI145472

Products & Services: Mutagenesis Services

The full spectrum of OCT1 (SLC22A1) mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics

Authors: Sook Wah Yee; Christian B. Macdonald; Darko Mitrovic; Xujia Zhou; Megan L. Koleske; Jia Yang; Dina Buitrago Silva; Patrick Rockefeller Grimes; Donovan D. Trinidad; Swati S. More; Linda Kachuri; John S. Witte; Lucie Delemotte; Kathleen M. Giacomini; Willow Coyote-Maestas

Journal: Molecular Cell

PubMed ID: 38703769

Doi: 10.1016/j.molcel.2024.04.008

Products & Services: Mutagenesis Services

Genetic and phenotypic heterogeneity in KIAA0753-related ciliopathies

Authors: Katherine A Inskeep, Yuri A Zarate, Danielle Monteil, Jurgen Spranger, Dan Doherty, Rolf W Stottmann, K Nicole Weaver

Journal: Am J Med Genet A

PubMed ID: 34523780

Doi: 10.1002/ajmg.a.62497

Products & Services: Mutagenesis Services

Exploration of the Role of the C-Terminal Domain of Human DNA Topoisomerase IIα in Catalytic Activity

Authors: Ashley C Dougherty, Mariam G Hawaz, Kristine G Hoang, Judy Trac, Jacob M Keck, Carmen Ayes, Joseph E Deweese

Journal: ACS Omega

PubMed ID: 34660952

Doi: 10.1021/acsomega.1c02083

Products & Services: Mutagenesis Services

The DNA Recognition Motif of GapR Has an Intrinsic DNA Binding Preference towards AT-rich DNA

Authors: Qian Huang, Bo Duan, Zhi Qu, Shilong Fan, Bin Xia

Journal: Molecules

PubMed ID: 34641320

Doi: 10.3390/molecules26195776

Products & Services: Mutagenesis Services

A Secreted Chorismate Mutase from pv Attenuates Virulence and Walnut Blight Symptoms

Authors: Renata de A B Assis, Cíntia H D Sagawa, Paulo A Zaini, Houston J Saxe, Phillip A Wilmarth, Brett S Phinney, Michelle Salemi, Leandro M Moreira, Abhaya M Dandekar

Journal: Int J Mol Sci

PubMed ID: 34638715

Doi: 10.3390/ijms221910374

Products & Services: Mutagenesis Services

Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue

Authors: Juan Luis Pacheco-Garcia, Ernesto Anoz-Carbonell, Pavla Vankova, Adithi Kannan, Rogelio Palomino-Morales, Noel Mesa-Torres, Eduardo Salido, Petr Man, Milagros Medina, Athi N Naganathan, Angel L Pey

Journal: Redox Biol

PubMed ID: 34537677

Doi: 10.1016/j.redox.2021.102112

Products & Services: Mutagenesis Services

Human Cystathionine γ-Lyase Is Inhibited by -Nitrosation: A New Crosstalk Mechanism between NO and HS

Authors: Dalila G F Fernandes, João Nunes, Catarina S Tomé, Karim Zuhra, João M F Costa, Alexandra M M Antunes, Alessandro Giuffrè, João B Vicente

Journal: Antioxidants (Basel)

PubMed ID: 34573023

Doi: 10.3390/antiox10091391

Products & Services: Mutagenesis Services

Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3

Authors: Allison Bakovic, Nishank Bhalla, Farhang Alem, Catherine Campbell, Weidong Zhou, Aarthi Narayanan

Journal: Viruses

PubMed ID: 34452398

Doi: 10.3390/v13081533

Products & Services: Mutagenesis Services

MicroRNA-138 Increases Chemo-Sensitivity of Glioblastoma through Downregulation of Survivin

Authors: Ji-Young Yoo, Margaret Yeh, Yin-Ying Wang, Christina Oh, Zhong-Ming Zhao, Balveen Kaur, Tae-Jin Lee

Journal: Biomedicines

PubMed ID: 34356844

Doi: 10.3390/biomedicines9070780

Products & Services: Mutagenesis Services