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Sudden death-associated KCNH2 variants exert opposing effects on a nuclear subdomain of the cardiac potassium channel hERG1

Authors: Francisco G Sanchez-Conde, Matthew R Goodrich, Olivia M Stack, Louis N R Goldberg, Pamela K Ruzycki, Abhilasha Jain, Eric N Jimenez-Vazquez, David K Jones

Journal: Molecular Therapy

PubMed ID: 41708004

Doi: 10.1016/j.jbc.2026.111296

Products & Services: Mutagenesis Services

Structural basis for the subtype-selectivity of KCa2.2 channel activators

Authors: Young-Woo Nam, Alena Ramanishka, Yang Xu, Rose Marie Haynes Yasuda, Joshua A Nasburg, Dohyun Im, Meng Cui, K George Chandy, Heike Wulff, Miao Zhang

Journal: Nature Communications

PubMed ID: 41507196

Doi: 10.1038/s41467-025-67232-3

Products & Services: Mutagenesis Services

G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails

Authors: Harrison A Fuchs, Yunhui Peng, Shine Ayyapan, Ruben Rosas, Houfang Zhang, Anna R Panchenko, Catherine A Musselman

Journal: Nucleic Acids Research

PubMed ID: 41533587

Doi: 10.1093/nar/gkaf1381

Products & Services: Mutagenesis Services

OMP16-targeting monoclonal antibodies H4 and E6 reveal essential linear epitopes for Brucella immunoprotection

Authors: Yunyi Zhai, Kaihui Sun, Ye Yuan, Xiaofang Liu, Gaowa Wudong, Yuanhao Yang, Shuan Qu, Yaxin Li, Dong Zhou, Wei Liu, Yaping Jin, Aihua Wang

Journal: International Journal of Biological Macromolecules

PubMed ID: 41448303

Doi: 10.1016/j.ijbiomac.2025.149881

Products & Services: Bacterial Expression Mutagenesis Services Peptide Synthesis

Structure of the human astrovirus capsid spike in complex with the neonatal Fc receptor

Authors: Adam Lentz, Sarah Lanning, Khurshid R Iranpur, Lena Ricemeyer, Carlos F Arias, Rebecca M DuBois

Journal: Nature Communications

PubMed ID: 41184319

Doi: 10.1038/s41467-025-65203-2.

Products & Services: Mutagenesis Services

Wild-type KRAS activation drives evasion of interferon-mediated immunity and resistance to immunotherapy in hepatocellular carcinoma

Authors: Martina Mang Leng Lei, Carmen Oi Ning Leung, Rainbow Wing Hei Leung, Xue Qian Wu, Katherine Po Sin Chung, Catherine Yu Jia Gu, Mandy Sze Man Chan, Wing Ki Chau, Quan Hua Mu, Kai Yu Ng, Man Tong, Jing Ping Yun, Jia Ming Nickolas Teo, Guang Sheng Ling, Patrick Pak Chun Wong, Stephen Lam Chan, Zhe Wen Xiong, Alfred Sze Lok Cheng, Jin Ding, Stephanie Ma, Terence Kin Wah Lee

Journal: Nature Communications

PubMed ID: 41219194

Doi: 10.1038/s41467-025-64860-7.

Products & Services: Mutagenesis Services

Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mapping

Authors: Inês De Magalhaes Pinheiro, John R D Dawson, Nicolas Calo, Marianne Paolini-Bertrand, Kalyana Bharati Akondi, Gavin Tan, Tracy M Handel, Irina Kufareva, Oliver Hartley

Journal: Nature Communications

PubMed ID: 40825773

Doi: 10.1038/s41467-025-62321-9.

Products & Services: Mutagenesis Services

Polycystin-1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1-Dependent Microfilament Remodeling

Authors: Jiaofeng Zhou, Yibing Deng, Jie Mei, Mengyun Wan, Ningyi Xue, Xinyu Zong, Ji Zhou, Junli Ding, Ting Yan, Yu Jiang, Tiansong Xia, Peng Zheng, Yichao Zhu

Journal: Advanced Science

PubMed ID: 40789101

Doi: 10.1002/advs.202509846

Products & Services: Mutagenesis Services

Modulation of the PTPRS proteoglycan switch by antibodies binding to the membrane-proximal fibronectin-type III domain

Authors: Thales Hein Da Rosa, Sterling H Ramsey, Judy J Lee, Natalia Y Kozlova, Zixuan Zhao, Jaeyeon Kim, Ava C Schneider, Sheng Li, Madhusudhanarao Katiki, Gary S Firestein, Ramachandran Murali, Eugenio Santelli, Stephanie M Stanford, Nunzio Bottini

Journal: The Journal of Biological Chemistry

PubMed ID: 40651610

Doi: 10.1016/j.jbc.2025.110470

Products & Services: Mutagenesis Services PCR Cloning and Subcloning Gene Synthesis

A single main-chain hydrogen bond required to keep GABAA receptors closed

Authors: Cecilia M Borghese, Jason D Galpin, Samuel Eriksson Lidbrink, Yuxuan Zhuang, Netrang G Desai, Rebecca J Howard, Erik Lindahl, Christopher A Ahern, Marcel P Goldschen-Ohm

Journal: Nature Communications

PubMed ID: 40603861

Doi: 10.1038/s41467-025-61447-0

Products & Services: Mutagenesis Services