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Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening， Optimization， and Biological Evaluation.

Authors: XueXiaoqian，ZhangYan，LiuZhaoxuan，SongMing，XingYanli，XiangQiuping，WangZhen，TuZhengchao，ZhouYulai，DingKe，Xu

Journal: J. Med. Chem.

PubMed ID: 26731490

Doi: 10.1021/acs.jmedchem.5b01511

Products & Services: Gene Synthesis

Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3.

Authors: ToonenLodewijk J A，SchmidtIris，LuijsterburgMartijn S，van AttikumHaico，van Roon-MomWilleke

Journal: Sci Rep

PubMed ID: 27731380

Doi: 10.1038/srep35200

Products & Services: Gene Synthesis

Comparative Community Proteomics Demonstrates the Unexpected Importance of Actinobacterial Glycoside Hydrolase Family 12 Protein for Crystalline Cellulose Hydrolysis.

Authors: HirasJennifer，WuYu-Wei，DengKai，NicoraCarrie D，AldrichJoshua T，FreyDario，KolinkoSebastian，RobinsonErrol W，JacobsJon M，AdamsPaul D，NorthenTrent R，SimmonsBlake A，SingerStev

Journal: MBio

PubMed ID: 27555310

Doi: 10.1128/mBio.01106-16

Products & Services: Gene Synthesis

Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals.

Authors: MaesoIgnacio，DunwellThomas L，WyattChris D R，MarlétazFerdinand，VetőBorbála，BernalJuan A，QuahShan，IrimiaManuel，HollandPeter

Journal: BMC Biol.

PubMed ID: 27296695

Doi: 10.1186/s12915-016-0267-0

Products & Services: Gene Synthesis

Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML.

Authors: HuangJu，LiuYuanfeng，AuBryan C，BarberDwayne L，ArrudaAndrea，SchambachAxel，RotheMichael，MindenMark D，PaigeChristopher J，MedinJeffr

Journal: Mol Ther Methods Clin Dev

PubMed ID: 27933304

Doi: 10.1038/mtm.2016.74

Products & Services: Gene Synthesis

Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology.

Authors: TatzelKatharina，KurokiLindsay，DmitrievIgor，KashentsevaElena，CurielDavid T，GoedegebuureS Peter，PowellMatthew A，MutchDavid G，HawkinsWilliam G，Spitzer

Journal: Sci Rep

PubMed ID: 26935795

Doi: 10.1038/srep22661

Products & Services: Gene Synthesis

Structure and Function of the RING Domains of RNF20 and RNF40， Dimeric E3 Ligases that Monoubiquitylate Histone H2B.

Authors: FoglizzoMartina，MiddletonAdam J，DayCatheri

Journal: J. Mol. Biol.

PubMed ID: 27569044

Doi: 10.1016/j.jmb.2016.07.025

Products & Services: Gene Synthesis

A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development.

Authors: HillJennifer Hampton，FranzosaEric A，HuttenhowerCurtis，GuilleminK

Journal: Elife

PubMed ID: 27960075

Doi: 10.7554/eLife.20145

Products & Services: Gene Synthesis

Targeted Delivery of Deoxycytidine Kinase to Her2-Positive Cells Enhances the Efficacy of the Nucleoside Analog Fludarabine.

Authors: KoduvayurSujatha P，SuYing，KayBrian K，LavieA

Journal: PLoS ONE

PubMed ID: 27280468

Doi: 10.1371/journal.pone.0157114

Products & Services: Gene Synthesis

Correction: Evidence for Reduced Drug Susceptibility without Emergence of Major Protease Mutations following Protease Inhibitor Monotherapy Failure in the SARA Trial.

Authors: SutherlandKatherine A，ParryChris M，McCormickAdele，KapaataAnne，LyagobaFred，KaleebuPontiano，GilksCharles F，GoodallRuth，SpyerMoira，KityoCissy，PillayDeenan，GuptaRavindr

Journal: PLoS ONE

PubMed ID: 27254277

Doi: 10.1371/journal.pone.0157094

Products & Services: Gene Synthesis