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Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding.

Authors: Beveridge R, Migas LG, Payne KAP, Scrutton NS, Leys D, Barran PE.

Journal: Nat Commun

PubMed ID: 27418477

Doi: 10.1038/ncomms12163

Products & Services: Gene Synthesis

A polymorphism of HMGA1 protects against proliferative diabetic retinopathy by impairing HMGA1-induced VEGFA expression.

Authors: Chiefari E, Ventura V, Capula C, Randazzo G, Scorcia V, Fedele M, Arcidiacono B, Nevolo MT, Bilotta FL, Vitiello M, Palmieri C, Gulletta E, Fusco A,, Foti D, Vero R, Brunetti A.

Journal: Sci Rep

PubMed ID: 27991577

Doi: 10.1038/srep39429

Products & Services: Gene Synthesis

Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum.

Authors: Dickerman Benjamin K，Elsworth Brendan，Cobbold Simon A，Nie Catherine Q，McConville Malcolm J，Crabb Brendan S，Gilson Pa

Journal: Sci Rep

PubMed ID: 27874068

Doi: 10.1038/srep37502

Products & Services: Gene Synthesis

COG lobe B sub-complex engages v-SNARE GS15 and functions via regulated interaction with lobe A sub-complex.

Authors: Willett Rose，Blackburn Jessica Bailey，Climer Leslie，Pokrovskaya Irina，Kudlyk Tetyana，Wang Wei，Lupashin Vlad

Journal: Sci Rep

PubMed ID: 27385402

Doi: 10.1038/srep29139

Products & Services: Gene Synthesis

Detection and Characterization of the Effect of AB-FUBINACA and Its Metabolites in a Rat Model.

Authors: Hsin-Hung Chen Michael，Dip Aybike，Ahmed Mostafa，Tan Michael L，Walterscheid Jeffrey P，Sun Hua，Teng Ba-Bie，Mozayani As

Journal: J. Cell. Biochem.

PubMed ID: 26517302

Doi: 10.1002/jcb.25421

Products & Services: Gene Synthesis

Energy- and carbon-efficient synthesis of functionalized small molecules in bacteria using non-decarboxylative Claisen condensation reactions.

Authors: CheongSeokjung，ClomburgJames M，GonzalezR

Journal: Nat. Biotechnol.

PubMed ID: 27088721

Doi: 10.1038/nbt.3505

Products & Services: Gene Synthesis

Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems.

Authors: NishidaKeiji，ArazoeTakayuki，YachieNozomu，BannoSatomi，KakimotoMika，TabataMayura，MochizukiMasao，MiyabeAya，ArakiMichihiro，HaraKiyotaka Y，ShimataniZenpei，KondoAki

Journal: Science

PubMed ID: 27492474

Doi: 10.1126/science.aaf8729

Products & Services: Gene Synthesis

Single-molecule Force Spectroscopy Reveals the Calcium Dependence of the Alternative Conformations in the Native State of a βγ-Crystallin Protein.

Authors: SchollZackary N，LiQing，YangWeitao，MarszalekPio

Journal: J. Biol. Chem.

PubMed ID: 27378818

Doi: 10.1074/jbc.M116.729525

Products & Services: Gene Synthesis

Pronuclear Injection-Based Targeted Transgenesis.

Authors: SchilitSamantha L P，OhtsukaMasato，QuadrosRolen M，GurumurthyChannabasavai

Journal: Curr Protoc Hum Genet

PubMed ID: 27727435

Doi: 10.1002/cphg.23

Products & Services: Gene Synthesis

Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.

Authors: SongSungWon，MirandaCarlos J，BraunLyndsey，MeyerKathrin，FrakesAshley E，FerraiuoloLaura，LikhiteShibi，BevanAdam K，FoustKevin D，McConnellMichael J，WalkerChristopher M，KasparBri

Journal: Nat. Med.

PubMed ID: 26928464

Doi: 10.1038/nm.4052

Products & Services: Gene Synthesis