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E. coli-mediated expedient biosynthesis of biotin-labeled ubiquitin probe enables activity-based profiling of deubiquitinases in cytoplasmic and nuclear compartments

Authors: Shuai Peng, Shaowen Wang, Xiaotong Liu, Hongrui Xu, Guoqiang Xu, Jia-bin Li

Journal: Chinese Chemical Letters

Doi: 10.1016/j.cclet.2025.111760

Products & Services: Codon Optimization Gene Synthesis PCR Cloning and Subcloning

Viral evolution prediction identifies broadly neutralizing antibodies to existing and rospective SARS-CoV-2 variants

Authors: Fanchong Jian, Anna Z Wec, Leilei Feng, Yuanling Yu, Lei Wang, Peng Wang, Lingling Yu, Jing Wang, Jacob Hou, Daniela Montes Berrueta, Diana Lee, Tessa Speidel, LingZhi Ma, Thu Kim, Ayijiang Yisimayi, Weiliang Song, Lu Liu, Sijie Yang, Xiao Niu, Tianhe Xiao, Ran An, Yao Wang, Fei Shao, Youchun Wang, Simone Pecetta, Xiangxi Wang, Laura M Walker, Yunlong Cao

Journal: Nature Microbiology

PubMed ID: 40494884

Doi: 10.1038/s41564-025-02030-7

Products & Services: Gene Synthesis Codon Optimization

Fidelity, specialization, and evolution of Paramecium PolX DNA polymerases involved in programmed double-strand break DNA repair

Authors: Nourisson Antonin , Missoury Sophia, Lucas-Staat Soizick , Haouz Ahmed , Delarue Marc

Journal: Nucleic Acids Research

PubMed ID: 40829804

Doi: 10.1093/nar/gkaf786

Products & Services: Gene Synthesis

Chemically modified tRNA enhances the translation capacity of mRNA rich in cognate codons

Authors: Liangzhen Dong, Jiayu Wang, Qing Xia

Journal: Nature Communications

PubMed ID: 40846860

Doi: 10.1038/s41467-025-62981-7.

Products & Services: Gene Synthesis

The Heme Oxygenase-Like Diiron Enzyme HrmI Reveals Altered Regulatory Mechanisms for Dioxygen Activation and Substrate N-Oxygenation

Authors: Sydney S Skirboll, Medha Gangopadhyay, Han N Phan, Joshua Hartsell, Aditi Mudireddy, Dalton Hilovsky, Paul D Swartz, Xiaojing Liu, Yisong Guo, Thomas M Makris

Journal: Journal of the American Chemical Society

PubMed ID: 40774922

Doi: doi.org/10.1021/jacs.5c08814

Products & Services: Gene Synthesis

Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery

Authors: Elias Adriaenssens, Stefan Schaar, Annan S I Cook, Jan F M Stuke, Justyna Sawa-Makarska, Thanh Ngoc Nguyen, Xuefeng Ren, Martina Schuschnig, Julia Romanov, Grace Khuu, Louise Uoselis, Michael Lazarou, Gerhard Hummer, James H Hurley, Sascha Martens

Journal: Nature Cell Biology

PubMed ID: 40715440

Doi: 10.1038/s41556-025-01712-y

Products & Services: Gene Synthesis

Modulation of the PTPRS proteoglycan switch by antibodies binding to the membrane-proximal fibronectin-type III domain

Authors: Thales Hein Da Rosa, Sterling H Ramsey, Judy J Lee, Natalia Y Kozlova, Zixuan Zhao, Jaeyeon Kim, Ava C Schneider, Sheng Li, Madhusudhanarao Katiki, Gary S Firestein, Ramachandran Murali, Eugenio Santelli, Stephanie M Stanford, Nunzio Bottini

Journal: The Journal of Biological Chemistry

PubMed ID: 40651610

Doi: 10.1016/j.jbc.2025.110470

Products & Services: Mutagenesis Services PCR Cloning and Subcloning Gene Synthesis

Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids

Authors: Kirsten Broderick, Mohamed Taha Moutaoufik, Tatiana Saccon, Ramy Malty, Shahreen Amin, Sadhna Phanse, Thomson Patrick Joseph, Mara Zilocchi, Ali Hosseinnia, Zoe Istace, Maryam Hajikarimlou, Sakib Abrar, Jade Fisher, Raelynn Brassard, Ranawaka Perera, Anil Kumar, Hiroyuki Aoki, Matineh Rahmatbakhsh, Matthew Jessulat, Darwyn Kobasa, Frank Dehne, Bhanu Prasad, Alla Gagarinova, M Joanne Lemieux, Alan Cochrane, Walid A Houry, Khaled A Aly, Ashkan Golshani, Mohan Babu

Journal: Nature Communications

PubMed ID: 40593736

Doi: 10.1038/s41467-025-60949-1

Products & Services: Gene Synthesis

CryoEM structure of the SLFN14 endoribonuclease reveals insight into RNA binding and cleavage

Authors: Justin Van Riper, Arleth O Martinez-Claros, Lie Wang, Hannah E Schneiderman, Sweta Maheshwari, Monica C Pillon

Journal: Nature Communications

PubMed ID: 40592880

Doi: 10.1038/s41467-025-61091-8

Products & Services: Gene Synthesis

CD19-ReTARGTPR: A Novel Fusion Protein for Physiological Engagement of Anti-CMV Cytotoxic T Cells Against CD19-Expressing Malignancies

Authors: Anne Paulien van Wijngaarden, Isabel Britsch, Matthias Peipp, Douwe Freerk Samplonius, Wijnand Helfrich

Journal: Cancers

PubMed ID: 40723184

Products & Services: Gene Synthesis