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Development of a Modular Vaccine Platform for Multimeric Antigen Display Using an Orthobunyavirus Model

Authors: Andrea Aebischer, Kerstin Wernike, Patricia König, Kati Franzke, Paul J Wichgers Schreur, Jeroen Kortekaas, Marika Vitikainen, Marilyn Wiebe, Markku Saloheimo, Ronen Tchelet, Jean-Christophe Audonnet, Martin Beer

Journal: Vaccines (Basel)

PubMed ID: 34203630

Doi: 10.3390/vaccines9060651

Products & Services: Peptide Synthesis

Identification of Cross-Reactive CD8 T Cell Receptors with High Functional Avidity to a SARS-CoV-2 Immunodominant Epitope and Its Natural Mutant Variants

Authors: Chao Hu, Meiying Shen, Xiaojian Han, Qian Chen, Luo Li, Siyin Chen, Jing Zhang, Fengxia Gao, Wang Wang, Yingming Wang, Tingting Li, Shenglong Li, Jingjing Huang, Jianwei Wang, Ju Zhu, Dan Chen, Qingchen Wu, Kun Tao, Da Pang, Aishun Jin

Journal: Genes Dis

PubMed ID: 34222571

Doi: 10.1016/j.gendis.2021.05.006

Products & Services: Peptide Synthesis

Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors

Authors: James C. Tarr; James M. Salovich; Martin Aichinger; KyuOk Jeon; Nagarathanam Veerasamy; John L. Sensintaffar; Heribert Arnhof; Matthias Samwer; Plamen P. Christov; Kwangho Kim; Tobias Wunberg; Norbert Schweifer; Francesca Trapani; Allison Arnold; Florian Martin; Bin Zhao; Nagaraju Miriyala; Danielle Sgubin; Stuart Fogarty; William J. Moore; Gordon M. Stott; Edward T. Olejniczak; Harald Engelhardt; Dorothea Rudolph; Taekyu Lee; Darryl B. McConnell; Stephen W. Fesik

Journal: Journal of Medicinal Chemistry

PubMed ID: 39102508

Doi: 10.1021/acs.jmedchem.4c01188

Products & Services: Peptide Synthesis

Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors

Journal: Journal of Medicinal Chemistry

PubMed ID: 39102508

Doi: 10.1021/acs.jmedchem.4c01188

Products & Services: Peptide Synthesis

Multi-Epitope Vaccine Design Using an Immunoinformatic Approach for SARS-CoV-2

Authors: Ye Feng, Haiping Jiang, Min Qiu, Liang Liu, Shengmei Zou, Yun Li, Qianpeng Guo, Ning Han, Yingqiang Sun, Kui Wang, Lantian Lu, Xinlei Zhuang, Shanshan Zhang, Shuqing Chen, Fan Mo

Journal: Pathogens

PubMed ID: 34208061

Doi: 10.3390/pathogens10060737

Products & Services: Peptide Synthesis

Yeast display of MHC-II enables rapid identification of peptide ligands from protein antigens (RIPPA)

Authors: Rongzeng Liu, Wei Jiang, Elizabeth D Mellins

Journal: Cell Mol Immunol

PubMed ID: 34117370

Doi: 10.1038/s41423-021-00717-5

Products & Services: Peptide Synthesis

Catalytic Dyad Residues His41 and Cys145 Impact the Catalytic Activity and Overall Conformational Fold of the Main SARS-CoV-2 Protease 3-Chymotrypsin-Like Protease

Authors: Juliana C Ferreira, Samar Fadl, Adrian J Villanueva, Wael M Rabeh

Journal: Front Chem

PubMed ID: 34249864

Doi: 10.3389/fchem.2021.692168

Products & Services: Peptide Synthesis

The interplay of self-assembly and target binding in centrin 1 from Toxoplasma gondii

Authors: Carolina Conter, Luca Bombardi, Marco Pedretti, Filippo Favretto, Adele Di Matteo, Paola Dominici, Alessandra Astegno

Journal: Biochem J

PubMed ID: 34114596

Doi: 10.1042/BCJ20210295

Products & Services: Peptide Synthesis

Thrombus-targeted nanoparticles for thrombin-triggered thrombolysis and local inflammatory microenvironment regulation

Authors: Huijuan Zhang, Hongyan Qu, Qingqing He, Linyu Gao, Hongling Zhang, Yongfu Wang, Zhenzhong Zhang, Lin Hou

Journal: J Control Release

PubMed ID: 34214595

Doi: 10.1016/j.jconrel.2021.06.043

Products & Services: Peptide Synthesis

Identification of a Glypican-3 binding peptide from a phage-displayed peptide library for PET imaging of hepatocellular carcinoma

Authors: Jiayao Yan, Xiaoxiao Yu, Xiaotong Chen, Fangcen Liu, Fangjun Chen, Naiqing Ding, Lixia Yu, Fanyan Meng, Jie Shen, Jia Wei and Baorui Liu

Journal: Frontiers in Oncology

PubMed ID: 34150644

Products & Services: Peptide Synthesis