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PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins
Authors: Christopher R Horne, Toby A Dite, Samuel N Young, Lucy J Mather, Laura F Dagley, Jared L Johnson, Tomer M Yaron-Barir, Emily M Huntsman, Leonard A Daly, Dominic P Byrne, Antonia L Cadell, Boaz H Ng, Jumana Yousef, Dylan H Multari, Lianju Shen, Luke M McAloon, Gerard Manning, Mark A Febbraio, Anthony R Means, Lewis C Cantley, Maria C Tanzer, David R Croucher, Claire E Eyers, Patrick A Eyers, John W Scott, James M Murphy
Journal: Proc Natl Acad Sci U S A
PubMed ID: 39964718
Doi: 10.1073/pnas.2420961122
Products & Services: Peptide Synthesis   
Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50
Authors: Sarah N. Zvornicanin; Ala M. Shaqra; Julia Flynn; Heidi Carias Martinez; Weiping Jia; Stephanie Moquin; Dustin Dovala; Daniel N. Bolon; Nese Kurt Yilmaz; Celia A. Schiffer
Journal: MBio
PubMed ID: 40183562
Doi: 10.1128/mbio.04068-24
Products & Services: Peptide Synthesis   
Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling
Authors: Jeonghyeon Kwon, Haruya Kawase, Kenny Mattonet, Stefan Guenther, Lisa Hahnefeld, Jamal Shamsara, Jan Heering, Michael Kurz, Sina Kirchhofer, Cornelius Krasel, Michaela Ulrich, Margherita Persechino, Sripriya Murthy, Cesare Orlandi, Christian D Sadik, Gerd Geisslinger, Moritz Bünemann, Peter Kolb, Stefan Offermanns, Nina Wettschureck
Journal: Nature Communications
PubMed ID: 39920161
Doi: 10.1038/s41467-025-56713-0
Products & Services: Peptide Synthesis   
Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells
Authors: Mélanie Uguen, Devan J Shell, Madhushika Silva, Yu Deng, Fengling Li, Magdalena M Szewczyk, Ka Yang, Yani Zhao, Michael A Stashko, Jacqueline L Norris-Drouin, Jarod M Waybright, Serap Beldar, Justin M Rectenwald, Angie L Mordant, Thomas S Webb, Laura E Herring, Cheryl H Arrowsmith, Suzanne Ackloo, Steven P Gygi, Robert K McGinty, Dalia Barsyte-Lovejoy, Pengda Liu, Levon Halabelian, Lindsey I James, Kenneth H Pearce, Stephen V Frye
Journal: Nature Communications
PubMed ID: 39994194
Doi: 10.1038/s41467-025-57005-3
Products & Services: Peptide Synthesis   
Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50
Authors: Sarah N. Zvornicanin; Ala M. Shaqra; Julia Flynn; Heidi Carias Martinez; Weiping Jia; Stephanie Moquin; Dustin Dovala; Daniel N. Bolon; Nese Kurt Yilmaz; Celia A. Schiffer
Journal: MBio
PubMed ID: 40183562
Doi: 10.1128/mbio.04068-24
Products & Services: Peptide Synthesis   
Co-translational protein aggregation and ribosome stalling as a broad-spectrum antibacterial mechanism
Authors: Laleh Khodaparast, Ladan Khodaparast, Ramon Duran-Romaña, Guiqin Wu, Bert Houben, Wouter Duverger, Matthias De Vleeschouwer, Katerina Konstantoulea, Fleur Nysen, Thomas Schalck, Daniel J Curwen, Lisandra L Martin, Sebastien Carpentier, Bernard Scorneaux, Jan Michiels, Joost Schymkowitz, Frederic Rousseau
Journal: Nature Communications
PubMed ID: 39939597
Doi: 10.1038/s41467-025-56873-z
Products & Services: Peptide Synthesis   
Proteasomes accumulate in the plant apoplast where they participate in microbe-associated molecular pattern (MAMP)-triggered pathogen defense
Authors: Hana Zand Karimi, Kuo-En Chen, Marilee Karinshak, Xilin Gu, Jason K Sello, Richard D Vierstra
Journal: Nature Communications
PubMed ID: 39952938
Doi: 10.1038/s41467-025-56594-3
Products & Services: Peptide Synthesis   
Pan-Variant SARS-CoV-2 Vaccines Induce Protective Immunity by Targeting Conserved Epitopes
Authors: Masaud Shah, Sung Ung Moon, Ji-Yon Shin, Ji-Hye Choi, Doyoon Kim, Hyun Goo Woo
Journal: Advanced Science
PubMed ID: 40014015
Doi: 10.1002/advs.202409919
Products & Services: Peptide Synthesis   
Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50
Authors: Sarah N. Zvornicanin; Ala M. Shaqra; Julia Flynn; Heidi Carias Martinez; Weiping Jia; Stephanie Moquin; Dustin Dovala; Daniel N. Bolon; Nese Kurt Yilmaz; Celia A. Schiffer
Journal: MBio
PubMed ID: 40183562
Doi: 10.1128/mbio.04068-24
Products & Services: Peptide Synthesis   
The short conserved region-2 of LARP4 interacts with ribosome-associated RACK1 and promotes translation
Authors: Amitabh Ranjan, Sandy Mattijssen, Nithin Charlly, Isabel Cruz Gallardo, Leah F Pitman, Jennifer C Coleman, Maria R Conte, Richard J Maraia。
Journal: Nucleic Acids Res
PubMed ID: 39898547
Doi: 10.1093/nar/gkaf053
Products & Services: Peptide Synthesis   
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