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Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteins

Authors: Jia-Nan Gong, Tirta M Djajawi, Donia M Moujalled, Giovanna Pomilio, Tiffany Khong, Li-Ping Zhang, Pasquale L Fedele, Michael S Low, Mary Ann Anderson, Christopher D Riffkin, Christine A White, Ping Lan, Guillaume Lessene, Marco J Herold, Andreas Strasser, Andrew Spencer, George Grigoriadis, Andrew H Wei, Mark F van Delft, Andrew W Roberts, David C S Huang

Journal: Cell Death & Differentiation

PubMed ID: 40204951

Doi: 10.1038/s41418-025-01487-7

Products & Services: Peptide Synthesis

A WYL domain transcription factor regulates Lactiplantibacillus plantarum intestinal colonization via perceiving c-di-GMP

Authors: Quan Guo, Guangqiang Wang, Leijie Zheng, Hui Xue, Ruimin Wang, Yajing Fang, Jiachao Zhang

Journal: Nature Communications

PubMed ID: 40038299

Doi: 10.1038/s41467-025-57581-4

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AMPlify: attentive deep learning model for discovery of novel antimicrobial peptides effective against WHO priority pathogens

Authors: Chenkai Li; Darcy Sutherland; S. Austin Hammond; Chen Yang; Figali Taho; Lauren Bergman; Simon Houston; Ren L. Warren; Titus Wong; Linda M. N. Hoang; Caroline E. Cameron; Caren C. Helbing; Inanc Birol

Journal: BMC Genomics

PubMed ID: 35078402

Doi: 10.1186/s12864-022-08310-4

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AMPlify: attentive deep learning model for discovery of novel antimicrobial peptides effective against WHO priority pathogens

Journal: BMC Genomics

PubMed ID: 35078402

Doi: 10.1186/s12864-022-08310-4

Products & Services: Peptide Synthesis

AMPlify: attentive deep learning model for discovery of novel antimicrobial peptides effective against WHO priority pathogens

Journal: BMC Genomics

PubMed ID: 35078402

Doi: 10.1186/s12864-022-08310-4

Products & Services: Peptide Synthesis

Oxytocin induces embryonic diapause

Authors: Jessica L Minder, Sarah B Winokur, Janaye Stephens, Jie Tong, Naomi L Cassel, Luisa Schuster, Habon A Issa, Michael Cammer, Latika Khatri, Gaia Moisan, Maria Alvarado-Torres, Orlando Aristizábal, Youssef Z Wadghiri, Sang Yong Kim, Silvana Valtcheva, Catherine Pei-Ju Lu, Moses V Chao, Robert C Froemke

Journal: SCIENCE ADVANCES

PubMed ID: 40043121

Doi: 10.1126/sciadv.adt1763

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Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma

Authors: Hao Shi, Yajie Yang, Jiwei Gao, Satendra Kumar, Hong Xie, Ziqing Chen, Jiawen Lyu, Harri Sihto, Virve Koljonen, Silvia Vega-Rubin-de-Celis, Vladana Vukojevic, Filip Farnebo, Viveca Björnhagen, Anders Höög, C Christofer Juhlin, Linkiat Lee, Malin Wickström, Jürgen C Becker, John Inge Johnsen, Catharina Larsson, Weng-Onn Lui

Journal: Nature Communications

PubMed ID: 40108758

Doi: 10.1080/15548627.2025.2477385

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Large Library Docking for Polypharmacology

Authors: Yujin Wu; Seth Vigneron; Joao Braz; Karthik Srinivasan; Elissa A. Fink; Xi-Ping Huang; Xinyu Xu; Harald Huebner; Joseph Y. Kim; Jing Wang; Tara Pfeiffer; Kensuke Sakamoto; Dmytro S. Radchenko; Ramona M. Rodriguiz; Yurii S. Moroz; John J. Irwin; Peter Gmeiner; Christian Billesboelle; Bryan L. Roth; Allan I. Basbaum; Aashish Manglik; William C. Wetsel; Brian K. Shoichet

Journal: Journal of Medicinal Chemistry

PubMed ID: 41712624

Doi: 10.1021/acs.jmedchem.5c03810

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Cell-autonomous innate immunity by proteasome-derived defence peptides

Authors: Karin Goldberg, Arseniy Lobov, Paola Antonello, Merav D Shmueli, Idan Yakir, Tal Weizman, Adi Ulman, Daoud Sheban, Einav Laser, Matthias P Kramer, Ronen Shteinvil, Guoyun Chen, Angham Ibraheem, Vera Sysoeva, Vered Fishbain-Yoskovitz, Gayatree Mohapatra, Anat Abramov, Sandy Shimshi, Kseniia Ogneva, Madhurima Nandy, Sivan Amidror, Hadar Bootz-Maoz, Shanny H Kuo, Nili Dezorella, Assaf Kacen, Aaron Javitt, Gee W Lau, Nissan Yissachar, Zvi Hayouka, Yifat Merbl

Journal: Nature

PubMed ID: 40044870

Doi: 10.1038/s41586-025-08615-w

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Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining

Authors: Yan Wang, Fuyuan Shen, Chen Zhao, Jiali Li, Wen Wang, Yamu Li, Jia Gan, Haojian Zhang, Xuefeng Chen, Qiang Chen, Fangyu Wang, Ying Liu, Yan Zhou

Journal: Nucleic Acids Res

PubMed ID: 40114375

Doi: 10.1093/nar/gkaf200

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