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Radiotherapy synergizes with an inducible AAVbased immunotherapy platform to program local and systemic antitumor immunity

Authors: Sonia Marco, Myriam Fernández, Beatriz Honorato, Nerea Juanarena, Cristina Sainz, Ainhoa Andueza, David J Gould, Seth Anderson, Carlos de Andrea, Paulo Pérez Domínguez, Paolo Wong, Carlos Vásquez, Irene Narinda, Carmen Unzu, Sergio Isola, Beatriz Tavira, Mikel Ariz, Gracián Camps, Miguel F Sanmamed, Julián Pardo, Sara Labiano, Marta M Alonso, Javier Marco-Sanz, Elizabeth Guruceaga, María Collantes, Jon Ander Simón, Iván Peñuelas, Joaquín Fernández-Irigoyen, Enrique Santamaría, Jesús Prieto, Juan Dubrot

Journal: Cancer Cell

PubMed ID: 41875889

Doi: doi.org/10.1016

Products & Services: Gene Synthesis

Structural basis for the subtype-selective activation of KCa3.1 channels

Authors: Alena Ramanishka, Joshua A. Nasburg, Yang Xu, Xinyi Ma, Reza Mehvar, Meng Cui, Young-Woo Nam, Heike Wulff, Miao Zhang

Journal: Structure

Doi: 10.1016/j.bpj.2025.11.2173

Products & Services: Gene Synthesis

Improved functional JAG1 and NOTCH2 variant testing in patients with clinical or suspected Alagille syndrome using new low-Notch activity cells

Authors: Nicole Buhl, Eva-Doreen Pfister, Daniel V Oliveira, Fabio Turetti, Eberhard Lurz, Ulrich Baumann, Nataliya Di Donato, Thomas Illig, Britta Skawran, Emma R Andersson, Jan Mašek, Amelie Stalke

Journal: Human Genetics

Doi: 10.1007/s00439-026-02832-7

Products & Services: Gene Synthesis

Harnessing Microbial Bioremediation and Wastewater Valorization for Production of (Methyl)muconates via Engineered Metabolic Pathways in Aromatic Pollutant Mixtures

Authors: Siqing Fan, Xueni Fu, Xiaoyu Wang, Lvjing Wang, Hongyu Chen, Christopher E French, Hongzhi Tang, Hao Ren, Zhenmei Lu

Journal: Environmental science & technology

PubMed ID: 42049681

Doi: 10.1021/acs.est.5c11064

Products & Services: Gene Synthesis

Prefusion-stabilized Hantaan virus glycoprotein nucleic acid vaccine elicits potent neutralizing antibody responses via germinal center activation

Authors: Wei Ye, Yamei Dang, Yuan Wang, Qiqi Yang, Hui Zhang, Chuantao Ye, Jing Wei, Jiawei Pei, Xuemin Pei, Dongshen Jiang, Xiaojing Yang, Xiaolei Jin, Hongwei Ma, He Liu, Liang Zhang, Linfeng Cheng, Yangchao Dong, Yingfeng Lei, Zhikai Xu, Fanglin Zhang

Journal: Nature Communications

PubMed ID: 41832144

Doi: 10.1038/s41467-026-70285-7

Products & Services: Gene Synthesis Protein Electrophoresis and Western

Catalytically active inclusion bodies of Bacillus clausii laccase protein recombinantly produced in E. coli for dye decolorization

Authors: Daniel Romero-Martínez, Francisco Gasteazoro, Luis F Cofas-Vargas, Enrique García-Hernández, Oscar González-Davis, Guadalupe Zavala, Diego Rosiles-Becerril, Rafael Vazquez-Duhalt, Mauricio A Trujillo-Roldán, Norma A Valdez-Cruz

Journal: Microbial cell factories

PubMed ID: 41792773

Doi: 10.1186/s12934-026-02949-4

Products & Services: Gene Synthesis

Oriented nanobody–field-effect transistor interfaces enable ultrasensitive cancer biomarker detection

Authors: Zhicheng Zhang, Duanlian Ye, Yuxuan Li, Guannan Li, Yanbo Jing, Jun Dai, Quan Wang, Tao Liu, Fan Xia, Xiaoding Lou

Journal: nature sensors

Doi: 10.1038/s44460-026-00040-4

Products & Services: Gene Synthesis

Chemically Synthesized H3K14Ub Unveils Clr4's IDR-Mediated Multivalent Nucleosome Recognition in H3K9 Methylation

Authors: Maoshen Sun, Yunxiang Du, Zhengqing Li, Akejiang Aderjiang, Meixuan Xin, Huasong Ai

Journal: ANGEWANDTE CHEMIE International Edition

PubMed ID: 41873495

Doi: 10.1002/anie.202520817

Products & Services: Gene Synthesis

N-Acetylcysteine–Mediated Surface Remodeling of Inhaled mRNA Lipid Nanoparticles Enables Coordinated Mucosal and Systemic Antitumor Immunity

Authors: Xingdi Cheng, Qing Li, Haowei Zu, Shuai Liu, Jingjiao Li, Yixing Wen, Chen Yang, Simin Sun, Haoyu Lu, Yuzhou Zhang, Yumeng Zhao, Guizhi Shi, Meng Qin, Xueguang Lu

Journal: ADVANCED MATERIALS

PubMed ID: 42124519

Doi: doi.org/10.1002/adma.73362

Products & Services: Gene Synthesis

Deciphering the Mechanism: Overcoming Incompatibility for Continuous Cap‑1 mRNA Synthesis via Multienzyme Cascades

Authors: Shiyi Che, , Zhengjun Li, Zhiguo Su, Aibing Yu, Minsu Liu, and Songping Zhang

Journal: ACS Sustainable Chemistry & Engineering

Doi: 10.1021/acssuschemeng.5c12019

Products & Services: Gene Synthesis