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Polyamine-dependent metabolic shielding regulates alternative splicing

Authors: Amaia Zabala-Letona, Mikel Pujana-Vaquerizo, Belen Martinez-Laosa, Maria Ponce-Rodriguez, Saioa Garcia-Longarte, Isabel Mendizabal, Ana Gimeno, Malgorzata Rogalska, Joycelyn Tan, Diana Cabrera, Sebastiaan van Liempd, Pilar Ximenez-Embun, Sergio Espinosa, Maider Fagoaga-Eugui, Francesca Peccati, Maciej Zakrzewski, Ianire Astobiza, Mikel Arana-Castañares, Sarah Cherkaoui, Maria Sendino, Inés Martín-Barros, Amaia Ercilla, Laura Bozal-Basterra, Onintza Carlevaris, Amaia Arruabarrena-Aristorena, Encarnación Pérez-Andrés, Telmo Santamaría-Zamorano, Juan A Ferrer-Bonsoms, Fernando Carazo, Maciej Cieśla, Cesar Lobato, Joan Seoane, Natalia Martín-Martín, Rosa Barrio, James D Sutherland, Ana M Aransay, Juan Manuel Falcón-Pérez, Barbara Martínez-Pastor, Angel Rubio, Francisco J Blanco, Michael D Hogarty, Raphael J Morscher, Edurne Berra, Remigiusz A Serwa, Jesús Jiménez-Barbero, Gonzalo Jiménez-Osés, Alejo Efeyan, Lydia Finley, Jose M Lizcano, Javier Muñoz, Juan Valcarcel, Arkaitz Carracedo

Journal: Nature

PubMed ID: 41535471

Doi: 10.1038/s41586-025-09965-1

Products & Services: Gene Synthesis

Staufen dsRNA-binding domain as modules to design bifunctional antibodies for siRNA delivery

Authors: Yahui Liu, Yan Zheng, Ruolin Xu, Yanan Quan, Wanyi Tai

Journal: Nucleic Acids Research

PubMed ID: 41569158

Doi: 10.1093/nar/gkaf1539

Products & Services: Gene Synthesis

FLIPs: Genetically encoded molecular biosensors for functional imaging of cell signaling by linear dichroism microscopy

Authors: Paul Miclea, Vendula Nagy-Marková, Robin Van den Eynde, Wim Vandenberg, Alina Sakhi, Alexey Bondar, Jitka Myšková, Peter Dedecker, Josef Lazar

Journal: SCIENCE ADVANCES

PubMed ID: 41544164

Doi: 10.1126/sciadv.adz5662

Products & Services: Gene Synthesis

Optimally engineered HLA/peptide-specific CAR-T cells outperform TCR-T cells to eradicate solid tumors

Authors: Corinne E Decker, Jacqueline Idun, Katja Mohrs, Thomas Craig Meagher, Iryna Petriv, Jonathon Golas, Robert Salzler, Timothy Helms, Dharani Ajithdoss, Suhasini Avvaru, Jiaxi Wu, Tong Zhang, Eric Smith, Gavin Thurston, John C Lin, Jessica R Kirshner, David J DiLillo

Journal: SCIENCE ADVANCES

PubMed ID: 41564177

Doi: 10.1126/sciadv.adx9371

Products & Services: Gene Synthesis

Mechanism of trans-envelope bacterial polysaccharide secretion in Class-3 outer-membrane polysaccharide export (OPX) protein systems

Authors: Abdelkader Mellouk, Kenny Ngo, Ahmad A Kezzo, Cyrielle Martini, Tanos C C França, Steven R Laplante, Salim T Islam, Charles Calmettes

Journal: Nature Communications

PubMed ID: 41545361

Doi: 10.1038/s41467-025-67321-3

Products & Services: Gene Synthesis

Thermodynamic Profiling Reveals DNA Polymerase Template Binding, Substrate Incorporation, and Exonuclease Function

Authors: Yaping Sun, Wu Lin, Kang Fu, Jie Gao, Xianhui Zhao, Yun He, Hui Tian

Journal: International Journal of Molecular Sciences

Doi: doi.org/10.3390/ijms262411909

Products & Services: Gene Synthesis Plasmid DNA Preparation Protein Electrophoresis and Western CRISPR KI Templates

A Multimodal Ensemble Framework for Optimal Mutant Prediction and Computational Enzyme Engineering

Authors: Ding Luo, Huining Ji, Baodong Hu, Jinxing Cai, Kaiqi Wen, Xiaoyang Qu, Mingfeng Cao, Xinrui Zhao, Binju Wang

Journal: ANGEWANDTE CHEMIE

PubMed ID: 41410226

Doi: 10.1002/anie.202521396

Products & Services: Gene Synthesis PCR Cloning and Subcloning

Study on the phosphorylation of NAD+-specific isocitrate dehydrogenase in the pathogenic bacteria Stenotrophomonas maltophilia and Xanthomonas sacchari

Authors: Qian Tian, Yongmei Zhang, Chunxu Pan, Linxiao Wang, Na Qin, Zhen Jiang, Chenxi Li, Zhengyu Cao, Guoping Zhu, Peng Wang

Journal: Journal of enzyme inhibition and medicinal chemistry

PubMed ID: 41395810

Doi: 10.1080/14756366.2025.2593798

Products & Services: Gene Synthesis Codon Optimization

Nuclear effects play an important role in determining codon usage-dependent human gene expression

Authors: Renu Garg, Pancheng Xie, Jiabin Duan, Huan Liu, Yi Liu

Journal: Nature Communications

PubMed ID: 41339630

Doi: 10.1038/s41467-025-65907-5

Products & Services: Gene Synthesis

Acyl-CoA-binding protein AcbdA is required for peroxisome hitchhiking on early endosomes in Aspergillus nidulans

Authors: Bellana E Driscoll, Madison B Fountain, Isabella N Gates, Reihane Abdollahi, Allison M Langley, Matthew B Owens, Jenna R Christensen, John Salogiannis

Journal: Molecular biology of the cell

PubMed ID: 40901736

Doi: 10.1091/mbc.e25-04-0186

Products & Services: Gene Synthesis PCR Cloning and Subcloning