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Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1
Authors: Xiangwei Wu, Yunxiang Du, Lu-Jun Liang, Ruichao Ding, Tianyi Zhang, Hongyi Cai, Xiaolin Tian, Man Pan, Lei Liu
Journal: Nat Commun .
PubMed ID: 38341401
Doi: 10.1038/s41467-024-45635-y
Products & Services: Gene Synthesis   
Mage Transposon: A Novel Gene Delivery System for Mammalian Cells
Authors: Jinghan Tian, Doudou Tong, Zhendong Li, Erqiang Wang, Yifei Yu, Hangya Lv, Zhendan Hu, Fang Sun, Guoping Wang, Min He, Tian Xia
Journal: Nucleic Acids Res .
PubMed ID: 38300794
Doi: 10.1093/nar/gkae048
Products & Services: Gene Synthesis   
Increasing β-hexosaminidase A activity using genetically modified mesenchymal stem cells
Authors: Alisa A Shaimardanova , Daria S Chulpanova , Valeriya V Solovyeva 1, Shaza S Issa , Aysilu I Mullagulova , Angelina A Titova , Yana O Mukhamedshina , Anna V Timofeeva , Alexander M Aimaletdinov , Islam R Nigmetzyanov , Albert A Rizvanov
Journal: Neural Regen Res .
PubMed ID: 37488869
Doi: 10.4103/1673-5374.375328
Products & Services: Gene Synthesis   
TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing
Authors: Kostantin Kiianitsa, Maria E Lukes, Brian J Hayes, Julianna Brutman, Paul N Valdmanis, Thomas D Bird, Wendy H Raskind, Olena Korvatska
Journal: Brain
PubMed ID: 38226698
Doi: 10.1093/brain/awae014
Products & Services: Gene Synthesis   Mutagenesis Services   Plasmid DNA Preparation   
Stabilization of the Metastable Pre-Fusion Conformation of the SARS-CoV-2 Spike Glycoprotein through N-Linked Glycosylation of the S2 Subunit
Authors: Fuwen Zan, Yao Zhou, Ting Chen , Yahan Chen, Zhixia Mu, Zhaohui Qian , Xiuyuan Ou
Journal: Viruses.
PubMed ID: 38399999
Doi: 10.3390/v16020223
Products & Services: Gene Synthesis   
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy
Authors: Binh An Nguyen , Virender Singh , Shumaila Afrin , Anna Yakubovska , Lanie Wang , Yasmin Ahmed , Rose Pedretti , Maria Del Carmen Fernandez-Ramirez , Preeti Singh , Maja Pękała , Luis O Cabrera Hernandez , Siddharth Kumar , Andrew Lemoff , Roman Gonzalez-Prieto , Michael R Sawaya , David S Eisenberg , Merrill Douglas Benson , Lorena Saelices
Journal: Nat Commun
PubMed ID: 38233397
Doi: 10.1038/s41467-024-44820-3
Products & Services: Gene Synthesis   
Cryo-EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH
Authors: Niraj Kumar , Shivani Sharma , Prem S Kaushal
Journal: Nat Commun
PubMed ID: 38245551
Doi: 10.1038/s41467-024-44879-y
Products & Services: Gene Synthesis   
Cyclic di-GMP inhibits nitrate assimilation by impairing the antitermination function of NasT in Pseudomonas putida
Authors: Liang Nie, Yujie Xiao, Tiantian Zhou, Haoqi Feng, Meina He, Qingyuan Liang, Kexin Mu, Hailing Nie, Qiaoyun Huang, Wenli Chen
Journal: Nucleic Acids Res
PubMed ID: 38000372
Doi: 10.1093/nar/gkad1117
Products & Services: Gene Synthesis   
Glycosylase-based base editors for efficient T-to-G and C-to-G editing in mammalian cells
Authors: Lijun Ye , Dongdong Zhao , Ju Li , Yiran Wang , Bo Li , Yuanzhao Yang , Xueting Hou , Huibin Wang , Zhandong Wei , Xiaoqi Liu , Yaqiu Li, Siwei Li , Yajing Liu , Xueli Zhang , Changhao Bi
Journal: Nat Biotechnol .
PubMed ID: 38168994
Doi: 10.1038/s41587-023-02050-w
Products & Services: Gene Synthesis   Gene Synthesis   
Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes
Authors: Zebin Tong , Huasong Ai, Ziyu Xu , Kezhang He , Guo-Chao Chu, Qiang Shi , Zhiheng Deng, Qiaomei Xue , Maoshen Sun, Yunxiang Du , Lujun Liang, Jia-Bin Li , Man Pan , Lei Liu
Journal: Nat Struct Mol Biol .
PubMed ID: 38177667
Doi: 10.1038/s41594-023-01141-1

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