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Machine learning-based analysis of the impact of 5′ untranslated region on protein expression

Authors: Linfeng Wang, Sujia Liu, Jia-Xin Huang, Haifeng Zhu, Shuyu Li, Yannan Li, Sen Chen, Jianying Han, Yin Zhu, Jiahao Wu, Wentao Liao, Hongmei Zhang, Haiyan Zeng, Shaoting Li, Shuping Zhao, Bingwei Wang, Jiaqi Lin, Ji Zeng

Journal: Nucleic Acids Research

PubMed ID: 40923765

Doi: 10.1093/nar/gkaf861

Products & Services: Gene Synthesis

De novo design of hypercompact transcript degraders by engineering substrate-specific toxins and Cas6-CBS system

Authors: Pin-Ru Chen, Pei-Pei Qin, Ya-Nan Wang, Peng-Fu Liu, Xin-Yue Zhang, Tao Qian, Bang-Ce Ye, Bin-Cheng Yin

Journal: Nat Commun

PubMed ID: 41006213

Doi: 10.1038/s41467-025-63166-y

Products & Services: Gene Synthesis

Biochemical Consequences of a Leucine-to-Cysteine Clamp Substitution in Lipoxygenases

Authors: Samuel G Hill, Katherine DeFeo, Adam R Offenbacher

Journal: Biomolecules

PubMed ID: 40867598

Doi: 10.3390/biom15081153

Products & Services: Gene Synthesis

Chimeric virus-like particles replacing the loop on the surface of VP60 from rabbit hemorrhagic disease virus (RHDV) provide protection against two serotypes of RHDV

Authors: Wangzhen Xiang, Beibei Pan, Yuxin Hao, Fei Wang, Jialu Bao, Shanchun Su, Shuai Qie, Chungang Pan, Zhen Cao, Xinyue Liu, Jiajun Wu, Tong Zhang, Xinyan Zhai, Fei Yang, Peng Qi, Jiangtao Wang, Jin Xiao, Xin Guo

Journal: Vaccine

PubMed ID: 40614613

Doi: 10.1016/j.vaccine.2025.127427

Products & Services: Gene Synthesis

Strengthening phage resistance of Streptococcus thermophilus by leveraging complementary defense systems

Authors: Audrey Leprince, Justine Lefrançois, Anne M Millen, Damian Magill, Philippe Horvath, Dennis A Romero, Geneviève M Rousseau, Sylvain Moineau

Journal: Nature Communications

PubMed ID: 40759662

Doi: 10.1038/s41467-025-62408-3.

Products & Services: Gene Synthesis

Guanidine aptamers are present in vertebrate RNAs associated with calcium signaling and neuromuscular function

Authors: Kumari Kavita, Aya Narunsky, Jessica J Mohsen, Isha Mahadeshwar, Michael G Mohsen, Yu-Shin Chang, Ronald R Breaker

Journal: Nature Communications

PubMed ID: 40783389

Doi: 10.1038/s41467-025-62815-6

Products & Services: Gene Synthesis

Dopamine signaling drives skin invasion by human-infective nematodes

Authors: Ruhi Patel, Gloria Bartolo, Michelle L Castelletto, Aracely Garcia Romero, Astra S Bryant, George W Agak, Elissa A Hallem

Journal: Nature Communications

PubMed ID: 40804046

Doi: 10.1038/s41467-025-62517-z.

Products & Services: Gene Synthesis

PIRT-Seq: a high-resolution whole-genome assay to identify protein-coding genes

Authors: Emily C A Goodall, Freya Hodges, Weine Kok, Budi Permana, Thom Cuddihy, Zihao Yang, Nicole Kahler, Kenneth Shires, Karthik Pullela, Von Vergel L Torres, Jessica L Rooke, Antoine Delhaye, Jean-François Collet, Jack A Bryant, Brian M Forde, Matthew R Hemm, Ian R Henderson

Journal: Nucleic Acids Research

PubMed ID: 40808296

Doi: 10.1093/nar/gkaf774

Products & Services: Gene Synthesis

A Bivalent mRNA Vaccine Efficiently Prevents Gammaherpesvirus Latent Infection

Authors: Yannan Yin, Jinkai Zang, Huichun Shi, Zhuang Wang, Linlin Kuang, Shuxia Wang, Haikun Wang, Ning Li, Xiaozhen Liang, Zhong Huang

Journal: Vaccines

PubMed ID: 40872916

Products & Services: Gene Synthesis

ANovelDeNovoBiosyntheticPathwayforEfficientSynthesisof6′ SialyllactoseinEscherichiacoli

Authors: Manxiang Zhu,Hongzhi Xia, Xianhao Xu, Yanfeng Liu, Guocheng Du,XuKueqin Lv, Long Liu, Shixiu Cui, Jianghua Li, and Yingyue Li

Journal: Synthetic Biology

Doi: 10.1021/acssynbio.5c00437

Products & Services: Gene Synthesis