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Defining essential charged residues in fibril formation of a lysosomal derived N-terminal α-synuclein truncation

Authors: Ryan P McGlinchey, Sashary Ramos, Emilios K Dimitriadis, C Blake Wilson, Jennifer C Lee

Journal: Nature Communications

PubMed ID: 40268916

Doi: 10.1038/s41467-025-58899-9

Products & Services: Gene Synthesis

Architecture and conformational dynamics of the BAM-SurA holo insertase complex

Authors: Philippe A Lehner, Morris Degen, Roman P Jakob, Seyed Majed Modaresi, Morgane Callon, Björn M Burmann, Timm Maier, Sebastian Hiller

Journal: SCIENCE ADVANCES

PubMed ID: 40184469

Doi: 10.1126/sciadv.ads6094

Products & Services: Gene Synthesis

A powerful and highly efficient PAI-mediated transgenesis approach in Drosophila

Authors: Wangfei Shi, Xuedi Zhang, Angyang Sun, Jie Zheng, Kailong Zhuang, Ziheng Chen, Ju Peng, Pengchong Fu, Guanjun Gao

Journal: Nucleic Acids Research

PubMed ID: 40266685

Doi: 10.1093/nar/gkaf317

Products & Services: Gene Synthesis

Unexpected enzymatic function of an ancient nucleic acid-binding fold

Authors: Rylan R Watkins, Stella Bockelman, Anna Vradi, Kaylee Grabarkewitz, Alexa Pyun, Josephine Stark, Vicki H Wysocki, Juan D Alfonzo, Karin Musier-Forsyth

Journal: Nucleic Acids Research

PubMed ID: 40274265

Doi: 10.1093/nar/gkaf328

Products & Services: Gene Synthesis

DNA-guided transcription factor interactions extend human gene regulatory code

Authors: Zhiyuan Xie, Ilya Sokolov, Maria Osmala, Xue Yue, Grace Bower, J. Patrick Pett, Yinan Chen, Kai Wang, Ayse Derya Cavga, Alexander Popov, Sarah A. Teichmann, Ekaterina Morgunova, Evgeny Z. Kvon, Yimeng Yin & Jussi Taipale

Journal: Nature

PubMed ID: 40205063

Doi: 10.1038/s41586-025-08844-z

Products & Services: Gene Synthesis

Cryo-EM structures of the small-conductance Ca2+-activated KCa2.2 channel

Authors: Young-Woo Nam, Dohyun Im, Ana Santa Cruz Garcia, Marios L Tringides, Hai Minh Nguyen, Yan Liu, Razan Orfali, Alena Ramanishka, Grigore Pintilie, Chih-Chia Su, Meng Cui, Diomedes E Logothetis, Edward W Yu, Heike Wulff, K George Chandy, Miao Zhang

Journal: Nat Commun

PubMed ID: 40246884

Doi: /10.1038/s41467-025-59061-1

Products & Services: Gene Synthesis

Discovery of diverse and high-quality mRNA capping enzymes through a language model–enabled platform

Authors: Tianze Wang, Bowen R Qin, Sihong Li, Zimo Wang, Xuejian Li, Yuanxu Jiang, Chenrui Qin, Qi Ouyang, Chunbo Lou, Long Qian

Journal: SCIENCE ADVANCES

PubMed ID: 40203090

Doi: 10.1126/sciadv.adt0402

Products & Services: Gene Synthesis

Mechanistic understanding of UvrA damage detection and lesion hand-off to UvrB in Nucleotide Excision Repair

Authors: Marianna Genta, Giulia Ferrara, Riccardo Capelli, Diego Rondelli, Sarah Sertic, Martino Bolognesi, Menico Rizzi, Franca Rossi, David Jeruzalmi, Antonio Chaves-Sanjuan & Riccardo Miggiano

Journal: Nature Communications

PubMed ID: 40210888

Doi: 10.1038/s41467-025-58670-0

Products & Services: Gene Synthesis

Molecular basis of human GABA transporter 3 inhibition

Authors: Ravi Yadav, Gye Won Han, Cornelius Gati

Journal: Nature Communications

PubMed ID: 40268946

Doi: 10.1038/s41467-025-59066-w

Products & Services: Gene Synthesis

The structure and function of the ghrelin receptor coding for drug actions

Authors: Yuki Shiimura, Dohyun Im, Ryosuke Tany, Hidetsugu Asada, Ryoji Kise, Eon Kurumiya, Hideko Wakasugi-Masuho, Satoshi Yasuda, Kazuma Matsui, Jun-Ichi Kishikawa, Takayuki Kato, Takeshi Murata, Masayasu Kojima, So Iwata, Ikuo Masuho

Journal: Nat Struct Mol Biol

PubMed ID: 39833471

Doi: 39833471

Products & Services: Gene Synthesis