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Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells

Authors: Wenyang Li, Robert P Sparks, Cheng Sun, Yang Yang, Lorena Pantano, Rory Kirchner, Nahid Arghiani, Arden Weilheimer, Benjamin J Toles, Jennifer Y Chen, Sean P Moran, Victor Barrera, Zixiu Li, Peng Zhou, Meghan L Brassil, David Wrobel, Shannan J Ho Sui, Gary Aspnes, Michael Schuler, Jennifer Smith, Benjamin D Medoff, Chan Zhou, Carine M Boustany-Kari, Jörg F Rippmann, Daniela M Santos, Julia F Doerner, Alan C Mullen

Journal: Nature Communications

PubMed ID: 40025044

Doi: 10.1038/s41467-025-56900-z

Products & Services: Gene Synthesis

Jumbo phage killer immune system targets early infection of nucleus-forming phages

Authors: Li Yuping, Linlin Guan, Isabelle Becher, Kira S Makarova, Xueli Cao, Surabhi Hareendranath, Jingwen Guan, Frank Stein, Siqi Yang, Arne Boergel, Karine Lapouge, Kim Remans, David Agard, Mikhail Savitski, Athanasios Typas, Eugene V Koonin, Yue Feng, Joseph Bondy-Denomy

Journal: Cell

PubMed ID: 40112800

Doi: 10.1016/j.cell.2025.02.016

Products & Services: Gene Synthesis

Enhancing the Anticancer Activity of a Carcinoma-Directed Peptide–HLA-I Fusion Protein by Armoring with Mutein IFNα

Authors: Douwe Freerk Samplonius , Anne Paulien van Wijngaarden , Lisanne Koll , Xiurong Ke , Wijnand Helfrich

Journal: Int J Mol Sci

PubMed ID: 40243928

Doi: ijms26073178

Products & Services: Gene Synthesis

The conductance of KCNQ2 and its pathogenic variants is determined by individual subunit gating

Authors: Andy Hinojo-Perez, Jodene Eldstrom, Ying Dou, Allan Marinho-Alcara, Michaela A Edmond, Alicia de la Cruz, Marta E Perez Rodriguez, Maykelis Diaz-Solares, Derek M Dykxhoorn, David Fedida, Rene Barro-Soria

Journal: SCIENCE ADVANCES

PubMed ID: 40043113

Doi: 10.1126/sciadv.adr7012

Products & Services: Gene Synthesis

Integrative in silico and biochemical analyses demonstrate direct Arl3-mediated ODA16 release from the intraflagellar transport machinery

Authors: Jiaolong Wang, Rune T Kidmose, Niels Boegholm, Nevin K Zacharia, Mads B Thomsen, Anni Christensen, Tara Malik, Karl Lechtreck, Esben Lorentzen

Journal: The Journal of biological chemistry

PubMed ID: 39880089

Doi: 10.1016/j.jbc.2025.108237

Products & Services: Gene Synthesis Codon Optimization

Structure and dynamics of GAD65 in complex with an autoimmune polyendocrine syndrome type 2-associated autoantibody

Authors: Susanne H D Ständer, Cyril F Reboul, Sarah N Le, Daniel E Williams, Peter G Chandler, Mauricio G S Costa, David E Hoke, John D T Jimma, James Fodor, Gustavo Fenalti, Stuart I Mannering, Benjamin T Porebski, Peter Schofield, Daniel Christ, Malcolm Buckle, Sheena McGowan, Dominika Elmlund, Kasper D Rand, Ashley M Buckle

Journal: Nature Communications

PubMed ID: 40055307

Doi: 10.1038/s41467-025-57492-4

Products & Services: Gene Synthesis

SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair

Authors: Alexander J Garvin, Alexander J Lanz, George E Ronson, Matthew J W Mackintosh, Katarzyna Starowicz, Alexandra K Walker, Yara Aghabi, Hannah MacKay, Ruth M Densham, Jai S Bhachoo, Aneika C Leney, Joanna R Morris

Journal: Mol Cell

PubMed ID: 40054443

Doi: 10.1016/j.molcel.2025.02.004

Products & Services: Gene Synthesis Mutagenesis Services PCR Cloning and Subcloning Peptide Synthesis

ER nests are specialized ER subdomains in Arabidopsis where peroxisomes and lipid droplets form

Authors: Zachary J Wright , Nathan E Tharp , Bonnie Bartel

Journal: Developmental Cell

Doi: 10.1016/j.devcel.2025.03.005

Products & Services: Gene Synthesis Protein Electrophoresis and Western

Structure-Guided Development of Chemically Tailored Peptide Binders of RNF43/ZNRF3 to Enable Versatile Design of Membrane Protein-Targeting PROTACs

Authors: Jibin Cui , Qingyun Zheng , Yicheng Weng , Xiaoguo Zhai , Zhen Su , Yunxiang Du , Xiaoxiong Wei , Yuanyuan Yu , Qian Qu , Man Pan

Journal: Analytical Chemistry