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Regulated transformation system (RTS): sddi-mediated programmable shut-off and mode switching of base editors

Authors: Jiacheng Deng, Jian Zhou, Hongyong Xiang, Xueyuan Li, Xiang Han, Zhen Weng, Junbo Jia, Yingshuo Shao, Yang Sima, Ming Niu, Dongmeng Li, Hongsheng Ouyang, Bin Xu, Daxin Pang, Lin Yang, Hongming Yuan

Journal: Nucleic Acids Research

PubMed ID: 41909950

Doi: doi.org/10.1093/nar/gkag162

Products & Services: Gene Synthesis Codon Optimization

From Field Overexpression to Biochemical Function: PxCYP6B4 Mediated Hydroxylation Confers Pyrethroid Resistance in Plutella xylostella

Authors: Zhuoda Liu, Yifei Zhou, Dongliang Wang, Ruichi Li, Zhen Tian, Yifan Li, Jiyuan Liu

Journal: Journal of Agricultural and Food Chemistry

PubMed ID: 41645610

Doi: 10.1021/acs.jafc.6c00843

Products & Services: Gene Synthesis Codon Optimization

Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin

Authors: Gauri Deák, Hayden Burdett, James A Watson, Marcus D Wilson

Journal: Molecular Therapy

PubMed ID: 41709455

Doi: 10.1016/j.str.2026.01.008

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Heterologous vs. homologous vaccine regimens: Sulfated lactosyl archaeol (SLA) archaeosome-adjuvanted SARS-CoV-2 spike protein boost following an mRNA/LNP prime induces robust and balanced immune responses

Authors: Tyler M Renner, Gerard Agbayani, Hiva Azizi, Lise Deschatelets, Renu Dudani, Blair A Harrison, Usha D Hemraz, Roger Koukiekolo, Matthew Stuible, Yves Durocher, Michael J McCluskie, Bassel Akache

Journal: Vaccine

PubMed ID: 41505874

Doi: 10.1016/j.vaccine.2025.128182

Products & Services: Codon Optimization Gene Synthesis

Enhanced SfaTnpB enables single-base-specific, one-pot nucleic acid detection for high-sensitivity diagnostics

Authors: Bingrong Xu, Sheng Li, Yong Li, Shuhong Zhao, Xinyun Li, Jianlin Han, Di Wu, Shuaicheng Li, Ling Chen, Shengsong Xie, Xiaosong Han, Changzhi Zhao

Journal: Nucleic Acids Research

PubMed ID: 41505099

Doi: 10.1093/nar/gkaf1433

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Microbiota-induced T cell plasticity enables immune-mediated tumour control

Authors: Tariq A Najar, Yuan Hao, Yuhan Hao, Gabriela Romero-Meza, Alexandra Dolynuk, Emma Almo, Dan R Littman

Journal: Nature

PubMed ID: 41535459

Doi: 10.1038/s41586-025-09913-z

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Metal ions govern coronavirus endoribonuclease activity

Authors: Xionglue Wang, Jing Li, Zhichao Liu, Longfei Wang, Bin Zhu

Journal: Nucleic Acids Research

PubMed ID: 41533565

Doi: 10.1093/nar/gkaf1508

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Study on the phosphorylation of NAD+-specific isocitrate dehydrogenase in the pathogenic bacteria Stenotrophomonas maltophilia and Xanthomonas sacchari

Authors: Qian Tian, Yongmei Zhang, Chunxu Pan, Linxiao Wang, Na Qin, Zhen Jiang, Chenxi Li, Zhengyu Cao, Guoping Zhu, Peng Wang

Journal: Journal of enzyme inhibition and medicinal chemistry

PubMed ID: 41395810

Doi: 10.1080/14756366.2025.2593798

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Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies

Authors: Claudia V Perez Almeria, Omolade Otun, Roman Schlimgen, Thomas D Lamme, Lotte Di Niro, Caitrin Crudden, Jan Paul Bebelman, Noureldine Youssef, Lejla Musli, Shawn Jenjak, Vladimir Bobkov, Julia Drube, Carsten Hoffmann, Brian F Volkman, Sébastien Granier, Cherine Bechara, Marco Siderius, Raimond Heukers, Christopher T Schafer, Martine J Smit

Journal: Nature Communications

PubMed ID: 41330916

Doi: 10.1038/s41467-025-65858-x

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Development of a cross-protective common cold coronavirus vaccine

Authors: Tanushree Dangi, Shiyi Li, Pablo Penaloza-MacMaster

Journal: Journal of virology

PubMed ID: 41123344

Doi: 10.1128/jvi.01526-25

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