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Efficient, cell-type-specific production of flavonols by multiplexed CRISPR activation of a suite of metabolic enzymes

Authors: Anaxi Houbaert, Valérie Denervaud Tendon, Lukas Hoermayer, Nicholas Morffy, Lucia C Strader, Niko Geldner

Journal: Nature Communications

PubMed ID: 40670339

Doi: 10.1038/s41467-025-61742-w

Products & Services: Codon Optimization

Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition

Authors: Yiru Wang, Lixia Zhao, Yi Zhang, Xiuxia Gao, Yannan Wang, Wenping Shi, Roger D Kornberg, Heqiao Zhang

Journal: Cell

PubMed ID: 40628260

Doi: 10.1016/j.cell.2025.06.017

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A novel and sensitive AuNPs/tetracystein-glucose dehydrogenase(GDH)/ screen-printed electrode(SPE)-based electrochemical glucose biosensor

Authors: Ting Zhang , Danni Ma , Fuman Cai

Journal: Microchemical Journal

Doi: doi.org/10.1016/j.microc.2025.114629

Products & Services: Codon Optimization Gene Synthesis Molecular Biology Reagents

Pol θ-mediated end-joining uses microhomologies containing mismatches

Authors: Yuzhen Li, Ngoc K Dang, Wei He, Mark Returan, Denisse Carvajal-Maldonado, Adele T Guerin, Han Xu, Bin Liu, Richard D Wood

Journal: Nature Communications

PubMed ID: 40603872

Doi: 10.1038/s41467-025-61258-3

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Rationally Designed TadA-Derived Cytosine Editors Enable Context-Independent Zebrafish Genome Editing

Authors: Wei Qin, Sheng-Jia Lin, Yu Zhang, Kevin Huang, Cassidy Petree, Kevin Boyd, Pratishtha Varshney, Gaurav K Varshney

Journal: Advanced Science

PubMed ID: 40685751

Doi: 10.1002/advs.202509800

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Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination

Authors: Jaigeeth Deveryshetty, Ayush Mistry, Sushil Pangeni, Mohamed Ghoneim, Monica Tokmina-Lukaszewska, Steven K Gore, Jie Liu, Vikas Kaushik, Simrithaa Karunakaran, Angela Taddei, Wolf-Dietrich Heyer, Taekjip Ha, Brian Bothner, Edwin Antony

Journal: Nature Communications

PubMed ID: 40691144

Doi: 10.1038/s41467-025-61811-0

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Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial

Authors: Mangalakumari Jeyanathan, Sam Afkhami, Michael R D'Agostino, Imran Satia, Dominik K Fritz, Kate Miyasaki, Jann C Ang, Anna Zganiacz, Karen J Howie, Marilyn Swinton, Emilio Aguirre, Michael B Zheng, Natallia Kazhdan, Anna Dvorkin-Gheva, Lawrence Mbuagbaw, Maria Fe C Medina, Nermin Diab, Danica L Brister, Gail M Gauvreau, Brian D Lichty, Matthew S Miller, Fiona Smaill, Zhou Xing

Journal: Nature Communications

PubMed ID: 40603330

Doi: 10.1038/s41467-025-60726-0

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A four-in-one replicase integrating key enzymatic activities for DNA replication

Authors: Yuxin Zhang , Xueling Lu , Bin Zhu , Fengtao Huang

Journal: Nucleic Acids Research

PubMed ID: 40548937

Doi: 10.1093/nar/gkaf542

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Design and Semisynthesis of Ubiquitin Extension Probes for Structural Analysis of Cullin1-Mediated Substrate Polyubiquitination

Authors: Chuntong Li, Fangyu Zhao, Chong Zuo, Liying Zhang, Yangwode Jing, Xu Li, Guo-Chao Chu, Luyu Shi, Yingyue Zhang, Han Wang, Shuzhe Sun, Maoshen Sun, Huasong Ai, Lu-Jun Liang, Jinghong Li

Journal: Journal of the American Chemical Society

PubMed ID: 40561458

Doi: 10.1021/jacs.5c06399

Products & Services: Gene Synthesis Codon Optimization

Designing Sandwich ELISA with Broadly Reactive Anti-Nucleocapsid Monoclonal Antibodies to Detect Bat-Borne Merbecoviruses

Authors: Kong Yen Liew, Yaju Wang, Sneha Sree Mullapudi, Dinah Binte Aziz, Wenjie Fan, Min Luo, Paul Anantharajah Tambyah, Yee-Joo Tan

Journal: Viruses

PubMed ID: 40733504

Doi: 10.3390/v17070886

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