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WTAP resists cholestatic liver injury by m6A-IGF2BP1-dependent regulation of the nuclear receptor FXR

GUT. 2026-10; 
Guomin Ju, Tong Wu, Yu Wu, Xueyu Zhou, Yang Yang, Xiangwen Meng, Cheng Jin, Hui Chen, Ke Sun, Ming Yu, Qinfen Xie, Shusen Zheng, Jian Wu, Chuanhui Peng
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Protein Electrophoresis and Western Equal quantities of protein samples were resolved via 4–12% SDS- polyacrylamide gel electropho resis (SDS- PAGE, GenScript, Nanjing, China), Get A Quote

摘要

Background Cholestatic liver injury is characterised by bile acid accumulation, hepatocyte damage and inflammatory response, leading to fibrosis and potential cirrhosis. Wilms’ tumour-1 associated protein (WTAP), a key regulator of N6-methyladenosine (m6A) modification, plays a crucial role in various diseases. However, the role of WTAP-mediated m6A modification in cholestatic liver diseases has been rarely studied.

关键词

BILE ACID; CHOLESTASIS; METHYLATION
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