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TNF‑α regulates the osteogenic differentiation of bone morphogenetic factor 9 adenovirus‑transduced rat follicle stem cells via Wnt signaling

Mol Med Rep. 2020; 
Xinyue Li, Ge Ren, Changjun Cai, Xia Yang, Li Nie, Xueqin Jing, Conghua Li
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Molecular Biology Reagents … Flow cytometric analysis and multi-lineage differentiation were performed for the characterization of mesenchymal stem cells, as previously described (6). The identification of rDFCs and the determination of appropriate concentrations of TNF-α (10 ng/ml; GenScript) and DKK1 … Get A Quote

摘要

Periodontitis is a chronic infectious disease that alters the cellular microenvironment and promotes bone absorption. Bone morphogenetic protein 9 (BMP9) serves an important role in proliferation and differentiation, and tumor necrosis factor‑alpha (TNF‑α) is an important contributor to bone resorption. The present study aimed to investigate the effect of osteogenic differentiation in the presence of BMP9 and TNF‑α in rat follicle stem cells (rDFCs). rDFCs were transfected with adenoviruses expressing BMP9 (AdBMP9) and the expression levels of important proteins [BMP9, β‑catenin, glycogen synthase kinase 3β (GSK3β), phosphorylated‑GSK3β, calcium/calmodulin dependent protein kinase II and nemo li... More

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