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Ultrashort Peptide Theranostic Nanoparticles by Microfluidic-Assisted Rapid Solvent Exchange

IEEE Trans Nanobioscience. 2020; 
Ming Ni, Guillaume Tresset, Ciprian Iliescu, Charlotte A E Hauser
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Molecular Biology Reagents … nanostructured The correspondence should be addressed to Ciprian Iliescu (ciprian.iliescu@imt.ro) and Charlotte Hauser (charlotte.hauser@kaust.edu.sa). M. Mi is with GenScript, Zhenjiang, Jiangsu Province, PR China. (e … Get A Quote

摘要

Ultrashort peptides (USPs), composed of three to seven amino acids, can self-assemble into nanofibers in pure water. Here, using hydrodynamic focusing and a solvent exchange method on a microfluidic setup, we convert these nanofibers into globular nanoparticles with excellent dimensional control and polydispersity. Thanks to USP nanocarriers' structure, different drugs can be loaded. We used Curcumin as a model drug to evaluate the performance of USP nanocarriers as a novel drug delivery vehicle. These nanoparticles can efficiently cross the cell membrane and possess nonlinear optical properties. Therefore, we envisage USP nanoparticles as promising future theranostic nanocarriers.

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