| Products/Services Used | Details | Operation |
|---|---|---|
| Molecular Biology Reagents | The following primers (GenScript, Nanjing, China) were used: When A2780 cells grew to an abundance of 70 - 80%, treated with different concentrations of 4b for 24 h. | Get A Quote |
Many cancer cells critically rely on antioxidant systems for cell survival and are vulnerable to further oxidative impairment triggered by reactive oxygen species (ROS) generating agents. Therefore, the classical design and development of inhibitors that target the antioxidant defense enzymes such as thioredoxin reductase (TrxR) can be a promising anticancer strategy. Here, we show that a gold(I) complex containing an oleanolic acid derivative ( 4b ) induces ovarian cancer (OC) A2780 cells apoptosis by activating the endoplasmic reticulum stress (ERS). It can inhibit TrxR enzyme activity to elevate ROS, mediate ERS and mitochondrial dysfunction, finally leading to the A2780 cells cycle arrest and apoptosis. Not... More
