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Characterization of a Bivalent Vaccine Capable of Inducing Protection Against Both Ebola and Cross-clade H5N1 Influenza in Mice.

J. Infect. Dis.. 2015;

WongGary，QiuXiangguo，EbiharaHideki，FeldmannHeinz，KobingerGa

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Peptide Synthesis	Peptide pools consisting of 167 or 112 total 15mer peptides with 10-amino-acid overlaps were used for splenocyte stimulation, cor- responding to the entire ZGP (Genscript) or HA (Mimitopes) antigens, respectively.	Get A Quote

摘要

Ebola virus (EBOV) is a lethal pathogen that causes up to 90% mortality in humans， whereas H5N1 avian influenza has a 60% fatality rate. Both viruses are considered pandemic threats. The objective was to evaluate the protective efficacy of a bivalent， recombinant vesicular stomatitis virus vaccine expressing both the A/Hanoi/30408/2005 H5N1 hemagglutinin and the EBOV glycoprotein (VSVΔG-HA-ZGP) in a lethal mouse model of infection.