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Folate-targeted paclitaxel-conjugated polymeric micelles inhibits pulmonary metastatic hepatoma in experimental murine H22 metastasis models.

Int J Nanomedicine. 2014; 
ZhangYan,ZhangHui,WuWenbin,ZhangFuhong,LiuShi,WangRui,SunYingchun,TongTi,JingXi
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Proteins, Expression, Isolation and Analysis … Apoptosis of the tumor cells after being incubated with drugs for 24 hours and 72 hours, respectively, was detected using a Hoechst 33342/PI apoptosis detection kit (GenScript USA Inc., Piscataway, NJ, USA) by FACSCalibur™ Flow Cytometer (BD, Franklin Lakes, NJ, USA) … Get A Quote

摘要

Hepatocellular carcinoma shows low response to most conventional chemotherapies; additionally, extrahepatic metastasis from hepatoma is considered refractory to conventional systemic chemotherapy. Target therapy is a promising strategy for advanced hepatoma; however, targeted accumulation and controlled release of therapeutic agents into the metastatic site is still a great challenge. Folic acid (FA) and paclitaxel (PTX) containing composite micelles (FA-M[PTX]) were prepared by coassembling the FA polymer conjugate and PTX polymer conjugate. The main purpose of this study is to investigate the inhibitory efficacy of FA-M(PTX) on the pulmonary metastasis of intravenously injected murine hepatoma 22 (H22) on... More

关键词

folate receptor,paclitaxel,polymer–drug conjugate,pulmonary metastasis,targeted drug deli