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Correlation of 5-HTT, BDNF and NPSR1 gene polymorphisms with anxiety and depression in asthmatic patients.

Int. J. Mol. Med.. 2019-07; 
YangYuan,ZhaoMingzhe,ZhangYuqun,ShenXinhua,YuanYon
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Molecular Biology Reagents … Polymerase chain reaction (PCR) amplification and genotyping. Genotyping of BDNF, NPSR1 and 5-HTT was performed using the PCR-restriction fragment length polymorphism (PCR-RFLP) and direct sequencing (GenScript Corp., Nanjing, China) … Get A Quote

摘要

Asthmatic patients are known to have a higher risk of anxiety and depression. In the present study, we aimed to explore the association of serotonin transporter?(5-HTT), brain-derived neurotrophic factor?(BDNF) and neuropeptide?S receptor?1?(NPSR1) gene polymorphisms with anxiety and depression in asthmatic patients. This was a cross-sectional study conducted on 143?asthmatic patients and 175?healthy volunteers. Of the asthmatic patients, 49?suffered from anxiety and 12?exhibited signs of depression. Patients with a lower level of education were more prone to depression. Both anxiety and depression were associated with poor asthma control as evaluated by the Asthma Control Test?(ACT) score. The associatio... More

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