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A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma.

Oncotarget. 2015-02; 
WangFengfei,RemkeMarc,BhatKruttika,WongEric T,ZhouShuang,RamaswamyVijay,DubucAdrian,FonkemEkokobe,SalemSaeed,ZhangHongbing,HsiehTze-Chen,O'RourkeStephen T,WuLizi,LiDavid W,HawkinsCynthia,KohaneIsaac S,WuJoseph M,WuMin,TaylorMichael D,Wu
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Custom Vector Construction Control shRNA, PDGFRα-shRNA and PDGFRβ-shRNA plasmids were prepared using a vector (pRNAT-CMV3.2/Neo) from GenScript Get A Quote

摘要

Over-expression of PDGF receptors (PDGFRs) has been previously implicated in high-risk medulloblastoma (MB) pathogenesis. However, the exact biological functions of PDGFRα and PDGFRβ signaling in MB biology remain poorly understood. Here, we report the subgroup specific expression of PDGFRα and PDGFRβ and their associated biological pathways in MB tumors. c-MYC, a downstream target of PDGFRβ but not PDGFRα, is involved in PDGFRβ signaling associated with cell proliferation, cell death, and invasion. Concurrent inhibition of PDGFRβ and c-MYC blocks MB cell proliferation and migration synergistically. Integrated analysis of miRNA and miRNA targets regulated by both PDGFRβ and c-MYC reveals th... More

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