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The therapeutic antibody LM609 selectively inhibits ligand binding to human αVβ3 integrin via steric hindrance

Structure, . 2017; 
Andrew J. Borst, Zachary M. James, William N. Zagotta, ..., Frank DiMaio, Marija Backovic, David Veesler
Products/Services Used Details Operation
Gene Synthesis aV Gene (Residues 31-987) Genscript NCBI Accession Code: NM_002210 b3 Gene (Residues 27-718) Genscript NCBI Accession Code: NM_000212 pT350 Vector (Krey et al., 2010) N/A GST-FN9-11 pGEX6P1 Mark H. Ginsberg, MD N/A LM609 Fab This Paper N/A Get A Quote

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d Crystal structure of the LM609 antigen-binding fragment d LM609 binds to the headpiece region in all aVb3 integrin conformations d The LM609 epitope does not overlap with the RGD ligandbinding pocket d LM609 sterically hinders access of large ligands to the aVb3 RGD-binding site
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