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Connexin 43 Hemichannel as a Novel Mediator of Sterile and Infectious Inflammatory Diseases.

Sci Rep. 2018; 
LiWei,BaoGuoqiang,ChenWeiqiang,QiangXiaoling,ZhuShu,WangShuaiwei,HeMingzhu,MaGaifeng,OchaniMahendar,Al-AbedYousef,YangHuan,TraceyKevin J,WangPing,D'AngeloJohn,WangHai
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Peptide Synthesis Te apo-SAA is almost identical to human Apo-SAA1α, except for the presence of an N-terminal methionine, the substitution of asparagine for aspartic acid at position 60, and arginine for histidine at position 71, the latter two substituted residues are present in Apo-SAA2β. GAP26 (VCYDKSFPISHVR), TAT-GAP19 (YGRKKRRQRRRK-QIEIKKFK) and P5 (ENVCYD) were synthesized by Genscript (Piscataway, NJ). Get A Quote

摘要

Cytoplasmic membrane-bound connexin 43 (Cx43) proteins oligomerize into hexameric channels (hemichannels) that can sometimes dock with hemichannels on adjacent cells to form gap junctional (GJ) channels. However, the possible role of Cx43 hemichannels in sterile and infectious inflammatory diseases has not been adequately defined due to the lack of selective interventions. Here we report that a proinflammatory mediator, the serum amyloid A (SAA), resembled bacterial endotoxin by stimulating macrophages to up-regulate Cx43 expression and double-stranded RNA-activated protein kinase R (PKR) phosphorylation in a TLR4-dependent fashion. Two well-known Cx43 mimetic peptides, the GAP26 and TAT-GAP19, diverg... More

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