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Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells.

Cell Commun. Signal. 2019-02;

WangFeixia, JiaYan, LiMengmeng, WangLing, ShaoJiangjuan, GuoQinglong, TanShanzhong, DingHai, ChenAnping, ZhangFeng, ZhengShiz

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Gene Synthesis	… Fold changes in the mRNA levels of target genes were related to the invariant control glyceraldehyde phosphate dehydrogenase (GAPDH). The primers (GenScript Co., Ltd., Nanjing, China) are listed in Additional file 1: Table S1. Western blot assay …	Get A Quote

摘要

Contraction of hepatic stellate cells (HSCs) plays an important role in the pathogenesis of liver fibrosis by regulating sinusoidal blood flow and extracellular matrix remodeling. Here， we investigated how HSC contraction was affected by the natural compound oroxylin A， and elucidated the underlying mechanism.