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3'-Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis.

Br. J. Pharmacol.. 2018-08; 
KangLi-Jung，KwonEun-Soo，LeeKwang Min，ChoChanmi，LeeJae-In，RyuYoung Bae，YoumTae Hyun，JeonJimin，ChoMi Ra，JeongSeon-Yong，LeeSang-Rae，KimWook，YangSiy
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Recombinant Proteins … 3′-SL and recombinant proteins (IL-1β, IL-6, IL-17, and TNF-α) were purchased from GeneChem Inc. (Daejeon, South Korea) and GenScript (Piscataway, NJ, USA), respectively. All reagents were dissolved in sterilized water prior to use. Human RA-FLS (Cell … Get A Quote

摘要

3'-Sialyllactose (3'-SL) is a safe compound that is present in high levels in human milk. Although it has anti-inflammatory properties and supports immune homeostasis， its effect on collagen-induced arthritis (CIA) is unknown. In this study， we investigated the prophylactic and therapeutic effect of 3'-SL on the progression of rheumatoid arthritis (RA) in in vitro and in vivo models.

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